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GENE:

KIF20A (Kinesin Family Member 20A)

News alerts, weekly reports and conference planners

FOXK1 induced upregulation of KIF20A promotes hepatocellular carcinoma progression via Wnt/β-Catenin/EMT signaling. (PubMed, Cell Mol Life Sci)

Wnt pathway activator SKL2001 and inhibitor LGK974 confirmed KIF20A's role in tumor progression...ChIP-seq and promoter assays verified FOXK1's direct binding to the KIF20A promoter, activating its transcription. In conclusion, KIF20A serves as a diagnostic and prognostic biomarker promoting HCC progression via Wnt/β-catenin signaling, regulated by FOXK1, offering new therapeutic targets.

4 days ago

Journal

KIF5B (Kinesin Family Member 5B) • CDH2 (Cadherin 2) • KIF13A (Kinesin Family Member 13A) • TWIST1 (Twist Family BHLH Transcription Factor 1) • KIF11 (Kinesin Family Member 11) • SNAI2 (Snail Family Transcriptional Repressor 2) • KIF20A (Kinesin Family Member 20A)

WNT974

KIF20A drives epithelial cell proliferation and migration in gastric adenocarcinoma, facilitating macrophage M2 polarization and subsequent immune evasion. (PubMed, Int J Biol Macromol)

Molecular docking identified a high-affinity interaction between sorafenib and KIF20A (binding energy: -6.11 kcal/mol), suggesting direct targeting. The current study unveiled KIF20A as a dual regulator of tumor-intrinsic malignancy and immune evasion, positioning sorafenib as a promising therapeutic agent to disrupt KIF20A-driven pathways in gastric adenocarcinoma.

4 days ago

Journal • IO biomarker

BCL2 (B-cell CLL/lymphoma 2) • SPP1 (Secreted Phosphoprotein 1) • CDC45 (Cell Division Cycle 45) • KIF20A (Kinesin Family Member 20A) • ORC1 (Origin Recognition Complex Subunit 1) • RUNX2 (RUNX Family Transcription Factor 2)

sorafenib

12d

KIF20A inhibits TRIM21-dependent ubiquitination of DHX9 to boost SOX2 stability, enhancing OSCC stemness and ferroptosis resistance. (PubMed, Cell Death Dis)

Notably, treatment with ENMD-2076 (identified through Connectivity Map analysis) significantly reduced KIF20A expression, attenuated CSC characteristics, augmented cisplatin sensitivity, and exerted marked antitumor activity. These findings elucidate a novel KIF20A-DHX9-SOX2 regulatory axis that simultaneously governs CSC maintenance and ferroptosis evasion in OSCC. Targeting KIF20A, either as a monotherapy or in combination with chemotherapy, may offer a promising strategy to improve therapeutic outcomes in OSCC.

12 days ago

Journal

SOX2 • KIF20A (Kinesin Family Member 20A) • TRIM21 (Tripartite Motif Containing 21)

cisplatin • ENMD-2076

17d

Targeting KIF20A: a new frontier in cancer treatment revealed by multi-omics analysis. (PubMed, Front Immunol)

Furthermore, in vivo experimental results indicate that interfering with KIF20A can inhibit tumor growth in nude mice. To our knowledge, this is the first study to reveal the role of KIF20A in tumorigenesis and development from a pan-cancer multi-omics perspective, providing solid theoretical and experimental evidence for KIF20A as a potential anti-cancer therapeutic target.

17 days ago

Journal • IO biomarker

KIF20A (Kinesin Family Member 20A)

According to the FRG model, individuals classified as low-risk exhibited more favorable survival prospects compared to their high-risk counterparts (P < .05). Overall, our investigation highlights the promise of FRGs as prognostic biomarkers and immunotherapy response in HCC, providing a novel approach for personalized patient management.

1 month ago

Retrospective data • Journal • Gene Signature • IO biomarker

MYCN (MYCN Proto-Oncogene BHLH Transcription Factor) • SLC1A5 (Solute Carrier Family 1 Member 5) • GPX4 (Glutathione Peroxidase 4) • SLC7A11 (Solute Carrier Family 7 Member 11) • KIF20A (Kinesin Family Member 20A)

Integrated Network Analysis Reveals a Directly Regulatory Network of FOXM1 Associated With the Cell Cycle in Lung Adenocarcinoma. (PubMed, Bioinform Biol Insights)

The predicted regulatory network of FOXM1 shows significant discrepancies with experimental validation data. Therefore, FOXM1's regulatory role in the cell cycle requires further experimental verification.

1 month ago

Journal

TOP2A (DNA topoisomerase 2-alpha) • FOXM1 (Forkhead Box M1) • MELK (Maternal Embryonic Leucine Zipper Kinase) • CENPF (Centromere Protein F) • KIF20A (Kinesin Family Member 20A)

Glycolysis reprogramming predicts poor prognosis and drives therapy resistance via CLN6 in lethal prostate cancer. (PubMed, Acta Biochim Biophys Sin (Shanghai))

In vitro, enzalutamide-resistant prostate cancer cell lines exhibit heightened glycolysis, and 2-DG inhibition reverses this effect, restoring drug sensitivity. CLN6 knockdown reduces glycolytic activity and cell proliferation. The GLY score offers robust prognostic value, and CLN6 represents a promising therapeutic target for precision medicine in lethal prostate cancer.

1 month ago

Journal

SDHC (Succinate Dehydrogenase Complex Subunit C) • SYNE1 (Spectrin Repeat Containing Nuclear Envelope Protein 1) • KIF20A (Kinesin Family Member 20A)

Xtandi (enzalutamide)

Integrating multiple key molecules in uveal melanoma to uncover metastatic and immune microenvironment-related gene signatures. (PubMed, Int J Ophthalmol)

This study establishes and validates a seven-gene signature associated with metastasis and prognosis in UVM. The findings provide a framework for understanding molecular determinants of tumor progression and immune microenvironment alterations, and may offer guidance for future mechanistic studies and therapeutic exploration.

1 month ago

Journal • Gene Signature

BAP1 (BRCA1 Associated Protein 1) • AURKA (Aurora kinase A) • KIF20A (Kinesin Family Member 20A) • UBE2C (Ubiquitin Conjugating Enzyme E2 C)

Differentially Expressed Genes Associated with the Development of Cervical Cancer. (PubMed, Int J Mol Sci)

The publicly available microarray datasets, including GSE39001, GSE9750, GSE7803, GSE6791, GSE63514, and GSE52903 in combination with bioinformatics database predictions, were used to identify differential expression genes, potential biomarkers, and therapeutic targets for cervical cancer; additionally, we undertook bioinformatic analysis to determine gene ontology and possible miRNA targets related to our DEGs...Interestingly, hub proteins KIF4A, NUSAP1, BUB1B, CEP55, DLGAP5, NCAPG, CDK1, MELK, KIF11, and KIF20A were found to be potentially regulated by several miRNAs, including miR-107, miR-124-3p, miR-147a, miR-16-5p, miR-34a-5p, miR-34c-5p, miR-126-3p, miR-10b-5p, miR-23b-3p, miR-200b-3p, miR-138-5p, miR-203a-3p, miR-214-3p, and let-7b-5p. The relationship between these genes highlights their potential as candidate biomarkers for further research in treatment, diagnosis, and prognosis.

1 month ago

Journal

TP53 (Tumor protein P53) • TOP2A (DNA topoisomerase 2-alpha) • RAD51 (RAD51 Homolog A) • MIR200B (MicroRNA 200b) • MIR34A (MicroRNA 34a-5p) • RAD51AP1 (RAD51 Associated Protein 1) • NUSAP1 (Nucleolar and Spindle Associated Protein 1) • ELF3 (E74 Like ETS Transcription Factor 3) • FOXM1 (Forkhead Box M1) • MELK (Maternal Embryonic Leucine Zipper Kinase) • CDK1 (Cyclin-dependent kinase 1) • KIF11 (Kinesin Family Member 11) • MIR126 (MicroRNA 126) • MIR16 (MicroRNA 16) • MIR23b (MicroRNA 23b) • NCAPG (Non-SMC Condensin I Complex Subunit G) • PLOD2 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 2) • BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) • CEP55 (Centrosomal Protein 55) • CXCL14 (C-X-C Motif Chemokine Ligand 14) • E2F1 (E2F transcription factor 1) • KIF20A (Kinesin Family Member 20A) • KIF4A (Kinesin Family Member 4A) • MCM2 (Minichromosome maintenance complex component 2) • MCM5 (Minichromosome Maintenance Complex Component 5) • MIR10B (MicroRNA 10b) • MIR138 (MicroRNA 138) • MIR203A (MicroRNA 203a) • MIR214 (MicroRNA 214) • MIRLET7B (MicroRNA Let-7b) • RELA (RELA Proto-Oncogene) • RFC4 (Replication Factor C Subunit 4) • MIR124-3 (MicroRNA 124-3)

2ms

Single-cell and machine learning-based analysis of the molecular mechanism of Banxia Xiexin Decoction in the treatment of gastric cancer. (PubMed, Cytotechnology)

We have established the correlation between the pathogenesis of GC's "cold and heat disorder" and modern pathological indicators (inflammation, oxidative damage, and cell apoptosis disorder) from the perspective of traditional Chinese medicine syndrome, providing a theoretical basis for the clinical application of BXXXD. The online version contains supplementary material available at 10.1007/s10616-025-00888-3.

2 months ago

Journal

CDC20 (Cell Division Cycle 20) • CDK1 (Cyclin-dependent kinase 1) • KIF11 (Kinesin Family Member 11) • KIF20A (Kinesin Family Member 20A) • KIF2C (Kinesin Family Member 2C)

2ms

Targeting kinesin family member 20A sensitizes stem-like triple-negative breast cancer cells to standard chemotherapy. (PubMed, J Clin Invest)

Therapeutically, KIF20A inhibition sensitizes TNBC xenografts to standard-of-care chemotherapy. Our study highlights the importance of targeting KIF20A to exploit BCSC vulnerabilities in TNBC.

2 months ago

Journal

HER-2 (Human epidermal growth factor receptor 2) • SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) • KIF20A (Kinesin Family Member 20A)

HER-2 expression