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    GENE:

    KHDRBS1 (KH RNA Binding Domain Containing, Signal Transduction Associated 1)

    i
    Other names: KHDRBS1, KH RNA Binding Domain Containing, Signal Transduction Associated 1, Src-Associated In Mitosis 68 KDa Protein, Sam68, KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein 1, P21 Ras GTPase-Activating Protein-Associated P62, GAP-Associated Tyrosine Phosphoprotein P62, P62, P68, KH Domain Containing, RNA Binding, Signal Transduction Associated 1, GAP-Associated Tyrosine Phosphoprotein P62 (Sam68), FLJ34027, SAM68
    2ms
    [Retracted] Clinical significance and effect of Sam68 expression in gastric cancer. (PubMed, Oncol Lett)
    [This retracts the article DOI: 10.3892/ol.2018.7930.].
    Journal
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    KHDRBS1 (KH RNA Binding Domain Containing, Signal Transduction Associated 1)
    2ms
    CD44v5 enhances the IL-4/IL-4Rα/STAT6/SAM68 aix inducing M2 polarization and promoting triple-negative breast cancer progression. (PubMed, Cancer Biol Ther)
    CD44v5 promotes M2 macrophage polarization by stabilizing and enhancing the IL-4Rα/STAT6/IL-4 signaling pathway, thereby facilitating the progression of triple-negative breast cancer. CD44v5 serves as an important therapeutic target for the reprogramming of both TAMs and M2 macrophages, thereby providing a novel strategy for the treatment of TNBC.
    Journal
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    IL6 (Interleukin 6) • KHDRBS1 (KH RNA Binding Domain Containing, Signal Transduction Associated 1) • STAT6 (Signal transducer and activator of transcription 6) • IL4 (Interleukin 4) • CD86 (CD86 Molecule)
    4ms
    Hypoxia-Induced circPRELID2 Promotes Gastric Cancer Metastasis by Facilitating ZEB2 Translation via PCBP1 O-GlcNAcylation. (PubMed, Adv Sci (Weinh))
    CircPRELID2 enhances OGT-mediated PCBP1 O-GlcNAcylation at Threonine 99 site in the cytoplasm, which disrupts the binding of PCBP1 to the 3'-UTR of ZEB2, resulting in the reversal of ZEB2 translation silencing, and ultimately promoting the EMT and metastasis of GC cells. These findings reveal a new regulatory mechanism of circRNA biogenesis, and also uncover that circPRELID2 participates in the translation of ZEB2 during GC metastasis via the modulation of PCBP1 O-GlcNAcylation, which provides a promising prognostic biomarker and therapeutic target for GC metastasis.
    Journal
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    HIF1A (Hypoxia inducible factor 1, alpha subunit) • KHDRBS1 (KH RNA Binding Domain Containing, Signal Transduction Associated 1) • ZEB2 (Zinc Finger E-Box Binding Homeobox 2)
    4ms
    Liquid-liquid phase separation-related genes in the immune microenvironment and diagnosis of focal segmental glomerulosclerosis and minimal change disease. (PubMed, Ren Fail)
    For MCD, the AUC values of PDS5A, KHDRBS1, and JUND were 1, 0.896, and 0.958, respectively. Immune infiltration analysis revealed that FSGS patients had higher levels of naive B cells while MCD patients had higher levels of M2 macrophages and resting mast cells.PDS5A may represent a potential diagnostic biomarker, and targeting its aberrant phase separation may offer a therapeutic strategy for podocytopathies.
    Journal
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    KHDRBS1 (KH RNA Binding Domain Containing, Signal Transduction Associated 1)
    6ms
    Somatic Mutations Profiling in Genes Other than BRCA and TP53 Increasing Breast Carcinoma Risk Among Pakistani Patients. (PubMed, Rev Recent Clin Trials)
    This study unveils new somatic alterations in different genes among early-onset Pakistani breast cancer patients, offering valuable insights for drug design targeting breast carcinoma.
    Journal • BRCA Biomarker
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    EGFR (Epidermal growth factor receptor) • TP53 (Tumor protein P53) • RB1 (RB Transcriptional Corepressor 1) • ARID1A (AT-rich interaction domain 1A) • FBXW7 (F-Box And WD Repeat Domain Containing 7) • KMT2C (Lysine Methyltransferase 2C) • BRCA (Breast cancer early onset) • CDH1 (Cadherin 1) • MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) • KHDRBS1 (KH RNA Binding Domain Containing, Signal Transduction Associated 1) • GATA3 (GATA binding protein 3) • DNAH8 (Dynein Axonemal Heavy Chain 8) • LAMA3 (Laminin Subunit Alpha 3) • TNN (Tenascin N) • CDC27 (Cell Division Cycle 27)
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    TP53 mutation • BRCA mutation
    6ms
    Exon Skipping of Ste20-Like Kinase Enhances Glycolysis and Tumor Progression by Activating Enolase 1-Mediated Phosphoenolpyruvate Production. (PubMed, Cancer Res)
    Targeting SLKv hindered glycolysis and tumorigenesis. These findings establish SLKv as a critical promoter of glycolysis and a metabolic target for cancer therapy.
    Journal
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    TGFB1 (Transforming Growth Factor Beta 1) • ENO1 (Enolase 1) • HK2 (Hexokinase 2) • KHDRBS1 (KH RNA Binding Domain Containing, Signal Transduction Associated 1)
    6ms
    Caerin 1.1/1.9 interfere KHDRBS1-DDX5 regulatory axis to induce IL-18 mediated pyroptosis in a HeLa cell tumour model. (PubMed, Sci Rep)
    Notably, KHDRBS1-deficint tumours displayed accelerated growth yet responded more robustly to F1F3 treatment, suggesting a context-dependent tumour-suppressive role of KHDRBS1. These findings uncover a previously uncharacterised pathway regulated by KHDRBS1-DDX5 and demonstrate that F1F3 can effectively interfere with this axis to induce anti-tumour immune responses, highlighting their potential as novel therapeutic agents for cervical cancer.
    Journal
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    IL18 (Interleukin 18) • DDX5 (DEAD-Box Helicase 5) • KHDRBS1 (KH RNA Binding Domain Containing, Signal Transduction Associated 1) • GSDME (Gasdermin E)
    6ms
    Tr-KIT Downstream Regulation by YY1 and NFYA Transcription Factors Knockdown in Prostate Cancer Cells. (PubMed, Genes Chromosomes Cancer)
    All in all, this study demonstrates that tr-KIT may be a potential pharmacological target for prostate cancer treatment and that inhibition of the transcription factors YY1 and NFYA may enhance the efficacy of Imatinib. SAM68 was found to be the most affected protein by the treatments, guiding future research.
    Journal
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    KHDRBS1 (KH RNA Binding Domain Containing, Signal Transduction Associated 1) • YY1 (YY1 Transcription Factor)
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    KIT expression
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    imatinib
    7ms
    FADD Activation in Hepatocellular Carcinoma Potentiates CD8+T Cell Responses and Sensitizes to Immune Checkpoint Inhibitors. (PubMed, Cancer Res)
    FADD activation through genetic or pharmacologic approaches overcame ICI resistance in orthotopic and spontaneous HCC mouse models in vivo. Together, these findings provide insights into combinatory immunotherapy approaches for HCC patients.
    Journal • Checkpoint inhibition
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    CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • FADD (Fas associated via death domain) • KHDRBS1 (KH RNA Binding Domain Containing, Signal Transduction Associated 1)
    9ms
    Multi-target RNA interference: A disruptive next-generation strategy for precision treatment of rheumatoid arthritis. (PubMed, Int Immunopharmacol)
    Although challenges such as stability, off-target effects, and efficient delivery remain, advancements in molecular modifications and nanoparticle technology offer promising solutions to these obstacles. In conclusion, unlike the traditional single-target DMARDs or biologics, multi-target RNA interference presents a highly precise mechanism to inhibit intracellular inflammatory cascade and joint damage progression in RA, offering a potential deterrent to disease advancement.
    Review • Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • KHDRBS1 (KH RNA Binding Domain Containing, Signal Transduction Associated 1) • NLRP3 (NLR Family Pyrin Domain Containing 3) • CCN1 (Cellular Communication Network Factor 1) • E2F2 (E2F Transcription Factor 2) • RELA (RELA Proto-Oncogene)
    1year
    The cryptic lncRNA-encoded microprotein TPM3P9 drives oncogenic RNA splicing and tumorigenesis. (PubMed, Signal Transduct Target Ther)
    High TPM3P9 expression or low RBM4 expression is associated with poor survival in patients with ccRCC. Collectively, our findings functionally and clinically characterize the "noncoding RNA"-derived microprotein TPM3P9 and thus identify potential prognostic and therapeutic factors in renal cancer.
    Journal
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    TPM3 (Tropomyosin 3) • RRM1 (Ribonucleotide Reductase Catalytic Subunit M1) • TCF7L2 (Transcription Factor 7 Like 2) • KHDRBS1 (KH RNA Binding Domain Containing, Signal Transduction Associated 1) • RBM4 (RNA Binding Motif Protein 4) • RELB (RELB Proto-Oncogene)
    1year
    KHDRBS1 regulates the pentose phosphate pathway and malignancy of GBM through SNORD51-mediated polyadenylation of ZBED6 pre-mRNA. (PubMed, Cell Death Dis)
    ZBED6 inhibited the transcription of G6PD by binding to the promoter region of G6PD. Therefore, the KHDRBS1/SNORD51/ZBED6 pathway performs an important part in regulating the pentose phosphate pathway to influence malignant biological behavior of GBM cells, providing new insights and potential targets for the treatment of GBM.
    Journal
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    KHDRBS1 (KH RNA Binding Domain Containing, Signal Transduction Associated 1)