^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    KHDRBS1 overexpression

    i
    Other names: KHDRBS1, KH RNA Binding Domain Containing, Signal Transduction Associated 1, Src-Associated In Mitosis 68 KDa Protein, Sam68, KH Domain-Containing, RNA-Binding, Signal Transduction-Associated Protein 1, P21 Ras GTPase-Activating Protein-Associated P62, GAP-Associated Tyrosine Phosphoprotein P62, P62, P68, KH Domain Containing, RNA Binding, Signal Transduction Associated 1, GAP-Associated Tyrosine Phosphoprotein P62 (Sam68), FLJ34027, SAM68
    Entrez ID:
    10657
    Related biomarkers:
    Fusion
    2years
    Shortening of the KHDRBS1 3'UTR by alternative cleavage and polyadenylation alters miRNA-mediated regulation and promotes gastric cancer progression. (PubMed, Am J Transl Res)
    Overexpression of KHDRBS1, especially KHDRBS1 with a shortened 3'UTR, promotes the growth and metastasis of GC in vivo and in vitro. In conclusion, the experimental results show that shortening of the KHDRBS1 mRNA 3'UTR can mediate the overexpression of KHDRBS1 in GC cells and promote the progression of GC.
    Journal
    |
    KHDRBS1 (KH RNA Binding Domain Containing, Signal Transduction Associated 1)
    |
    KHDRBS1 overexpression
    2years
    High expression of Sam68 contributes to metastasis by regulating vimentin expression and a motile phenotype in oral squamous cell carcinoma. (PubMed, Oncol Rep)
    Furthermore, the immunohistochemical study of vimentin identified the association between vimentin expression and Sam68 expression as well as cervical lymph node metastasis. In conclusion, the present study suggested that the high expression of Sam68 may contribute to metastasis by regulating vimentin expression and a motile mesenchymal phenotype in OSCC.
    Journal
    |
    VIM (Vimentin) • KHDRBS1 (KH RNA Binding Domain Containing, Signal Transduction Associated 1)
    |
    VIM expression • KHDRBS1 overexpression