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    BIOMARKER:

    KDR rs2071559

    i
    Other names: KDR, CD309, FLK1, VEGFR, VEGFR2, Kinase insert domain receptor (a type III receptor tyrosine kinase)
    Entrez ID:
    3791
    Related biomarkers:
    Expression
    Mutation
    CNA
    Others
    11ms
    The Relation of VEGFA, VEGFR2, VEGI, and HIF1A Genetic Variants and Their Serum Protein Levels with Breast Cancer in Egyptian Patients. (PubMed, Biochem Genet)
    Serum levels of VEGFA, VEGI, and HIF1A were considerably greater in women with breast cancer than in the control (p < 0.001). In conclusion, the genetic variants VEGFA rs25648, VEGFR2 rs2071559, and VEGI rs6478106 revealed a significant association with increased breast cancer risk in Egyptian patients.
    Journal
    |
    KDR (Kinase insert domain receptor) • HIF1A (Hypoxia inducible factor 1, alpha subunit)
    |
    KDR rs2071559
    3years
    Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Contributes to Tamoxifen Resistance in Estrogen-Positive Breast Cancer Patients (PubMed, Mol Biol (Mosk))
    A correlation between the mRNA of the ESR1 and KDR genes in patients without progression was detected. The results indicate the prognostic value of rs2305948 and its potential contribution to the tumor phenotype sensitive to tamoxifen.
    Clinical • Journal
    |
    ER (Estrogen receptor) • KDR (Kinase insert domain receptor) • VEGFA (Vascular endothelial growth factor A)
    |
    KDR expression • KDR rs2071559
    |
    tamoxifen
    almost4years
    Association of Genetic Variants in ANGPT/TEK and VEGF/VEGFR with Progression and Survival in Head and Neck Squamous Cell Carcinoma Treated with Radiotherapy or Radiochemotherapy. (PubMed, Cancers (Basel))
    These SNPs and their combinations were independent risk factors for specific endpoints. Our data suggest that certain germline variants in ANGPT2/TEK and VEGF/VEGFR2 axes may have predictive and prognostic potential in HNSCC treated with radiation or chemoradiation.
    Journal
    |
    KDR (Kinase insert domain receptor) • VEGFA (Vascular endothelial growth factor A) • FLT1 (Fms-related tyrosine kinase 1) • ANGPT2 (Angiopoietin 2)
    |
    KDR rs2071559
    4years
    Prognostic effect of VEGF gene variants in metastatic non-small-cell lung cancer patients. (PubMed, Angiogenesis)
    Our findings reinforce the potential clinical value of germline variants in VEGFA and VEGFR2 and show for the first time variants in ITGAV and MAPK11 as promising prognostic markers in metastatic NSCLC patients receiving platinum-based chemotherapy.
    Clinical • Journal
    |
    KRAS (KRAS proto-oncogene GTPase) • KDR (Kinase insert domain receptor) • VEGFA (Vascular endothelial growth factor A) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • FLT1 (Fms-related tyrosine kinase 1) • MAPK1 (Mitogen-activated protein kinase 1)
    |
    KDR rs2071559