KANK4 (KN Motif And Ankyrin Repeat Domains 4)

The ROC curve confirmed the model's robust prognostic predictive performance. This study presents a 5-gene prognostic risk prediction model for EC, including PDZ domain containing ring finger 3, KN motif and ankyrin repeat domains 4, prion protein, phosphoserine aminotransferase 1, and Annexin A1, which can effectively predict patients' prognosis and provide a reference for the clinical diagnosis and targeted therapy of EC.

Importantly, treatment with the DHCR7 inhibitors AY9944 and tamoxifen (TAM) significantly inhibited LNM of CC, suggesting the clinical application potential of DHCR7 inhibitors in CC. Collectively, our results uncover a novel molecular mechanism of LNM in CC and identify DHCR7 as a new potential therapeutic target.

Combination therapy with riluzole and sorafenib was safe and tolerable in patients with advanced solid tumors. The partial response in a patient with a RAF1 fusion suggests that further exploration in a genomically selected cohort may be warranted.

EMT related genes play an important role in tumor progression and immunity in BLCA. Our EMT risk score could accurately predict prognosis and immunophenotype of a single patient, which could guide more effective precision medical strategies.