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    almost3years
    Prognostic significance of CRLF2 overexpression and JAK2 mutation in Egyptian pediatric patients with B-precursor acute lymphoblastic leukemia. (PubMed, Clin Lymphoma Myeloma Leuk)
    CRLF2 expression was significantly higher in Egyptian precursor B-ALL pediatric patients. CRLF2 overexpression was associated with a number of unfavorable prognostic factors with high tumor load, but was not an adverse independent parameter in pediatric BCP-ALL patients. Some patients with CRLF2 overexpression display JAK2 mutation, which may benefit from targeted therapy by kinase inhibitors.
    Clinical • Journal
    |
    JAK2 (Janus kinase 2) • CRLF2 (Cytokine Receptor Like Factor 2)
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    JAK2 mutation • CRLF2 mutation • JAK2 R683G • JAK2 overexpression
    over3years
    A typical acute lymphoblastic leukemia JAK2 variant, R683G, causes an aggressive form of familial thrombocytosis when germline. (PubMed, Leukemia)
    No abstract available
    Journal
    |
    JAK2 (Janus kinase 2)
    |
    JAK2 R683G