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    DRUG:

    itraconazole

    Company:
    Generic mfg.
    Drug class:
    CYP51A1 inhibitor
    Related drugs:
    21h
    Сlinical Study Aiming to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Ascending Doses of ZE63-0302 in Healthy Volunteers (clinicaltrials.gov)
    P1, N=82, Completed, Eilean Therapeutics | Recruiting --> Completed
    Trial completion • First-in-human
    |
    itraconazole
    5d
    Mechanism-guided untargeted-to-targeted lipidomics identifies phosphatidylcholine 38:4 in rat bile as an Abcb4/Mdr2 inhibition marker. (PubMed, Drug Metab Dispos)
    Multistage collision-induced dissociation/mass spectrometry3 fragmentation further confirmed the identity as arachidonyl phosphatidylcholine 18:0/20:4. Its rapid and specific decline in the presence of the Mdr2 inhibitor itraconazole offers a potential new tool for early detection of human multidrug resistance protein 3-related liver injury risk during drug development.
    Preclinical • Journal
    |
    ABCB4 (ATP Binding Cassette Subfamily B Member 4)
    |
    itraconazole
    8d
    A Study to Learn if Itraconazole Changes How the Body Processes PF-07248144 (Study Medicine) (clinicaltrials.gov)
    P1, N=12, Active, not recruiting, Pfizer | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    itraconazole • prifetrastat (PF-07248144)
    8d
    A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 764198 in the Blood (clinicaltrials.gov)
    P1, N=14, Active, not recruiting, Boehringer Ingelheim
    Trial initiation date
    |
    itraconazole
    8d
    A Clinical Trial in Healthy Participants to Learn How Itraconazole Affects MK-2828 Levels and How MK-2828 Affects Midazolam Levels (MK-2828-007) (clinicaltrials.gov)
    P1, N=28, Recruiting, Merck Sharp & Dohme LLC | Not yet recruiting --> Recruiting
    Enrollment open
    |
    itraconazole • midazolam hydrochloride
    18d
    A Study Evaluating the Effects of Itraconazole or Rifampin on the Pharmacokinetic Characteristics of Rocbrutinib Tablet (clinicaltrials.gov)
    P1, N=28, Recruiting, Guangzhou Lupeng Pharmaceutical Company LTD. | Not yet recruiting --> Recruiting
    Enrollment open
    |
    itraconazole • rifampicin • rocbrutinib (LP-168)
    18d
    A Study to Evaluate VH4524184 Tablet Absorption, Effects of Food, and Interactions With Other Drugs in Healthy Adults (clinicaltrials.gov)
    P1, N=126, Completed, ViiV Healthcare | Recruiting --> Completed
    Trial completion
    |
    metformin • itraconazole
    22d
    A Study to Learn How Fluconazole, Carbamazepine and Itraconazole Affect How the Body Processes ASP3082 in Healthy Adults (clinicaltrials.gov)
    P1, N=54, Recruiting, Astellas Pharma Global Development, Inc. | Not yet recruiting --> Recruiting
    Enrollment open
    |
    KRAS (KRAS proto-oncogene GTPase)
    |
    setidegrasib (ASP3082) • itraconazole
    23d
    Drug-drug Interaction Trial of AP31969 and Carbamazepine or Itraconazole (clinicaltrials.gov)
    P1, N=28, Not yet recruiting, Acesion Pharma
    New P1 trial
    |
    itraconazole
    24d
    A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 764198 in the Blood (clinicaltrials.gov)
    P1, N=14, Active, not recruiting, Boehringer Ingelheim | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    itraconazole
    28d
    A Clinical Trial in Healthy Participants to Learn How Itraconazole Affects MK-2828 Levels and How MK-2828 Affects Midazolam Levels (MK-2828-007) (clinicaltrials.gov)
    P1, N=28, Not yet recruiting, Merck Sharp & Dohme LLC
    New P1 trial
    |
    itraconazole • midazolam hydrochloride
    28d
    Catequentinib Hydrochloride (AL3818) Drug-Drug Interaction Study in Healthy Volunteers (clinicaltrials.gov)
    P1, N=16, Not yet recruiting, Advenchen Laboratories Nanjing Ltd.
    New P1 trial
    |
    Focus V (anlotinib) • itraconazole