^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    DRUG:

    itraconazole

    Company:
    Generic mfg.
    Drug class:
    CYP51A1 inhibitor
    Related drugs:
    1d
    A Study of the Effects of Itraconazole on the Plasma Levels of Nemtabrutinib (MK-1026-013) (clinicaltrials.gov)
    P1, N=15, Completed, Merck Sharp & Dohme LLC
    New P1 trial
    |
    itraconazole • nemtabrutinib (MK-1026)
    1d
    A Phase 1 Study to Examine the Effects of Itraconazole After Single Dose Administration of Varegacestat (AL102) to Healthy Participants (clinicaltrials.gov)
    P1, N=22, Recruiting, Immunome, Inc. | Not yet recruiting --> Recruiting
    Enrollment open
    |
    itraconazole • varegacestat (AL102)
    1d
    MK-1708-008: A Study to Evaluate the Effects of Itraconazole on MK-1708 in Healthy Participants (MK-1708-003) (clinicaltrials.gov)
    P1, N=12, Active, not recruiting, Merck Sharp & Dohme LLC | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    itraconazole
    2d
    A Study to Investigate the Effects of Itraconazole on the Pharmacokinetics of PC14586 in Healthy Participants (clinicaltrials.gov)
    P1, N=12, Completed, PMV Pharmaceuticals, Inc | Recruiting --> Completed
    Trial completion
    |
    itraconazole • rezatapopt (PC14586)
    5d
    A Single-center, Open-label, Fixed-sequence, Drug-Drug Interaction Study of BPI-16350 co-administered with Rifampin or Itraconazole in Healthy Volunteers (ChiCTR2400090190)
    P1, N=36, Completed, Beijing Friendship Hospital ,Capital Medical University; Beijing Friendship Hospital ,Capital Medical University
    New P1 trial
    |
    itraconazole • tibremciclib (BPI-16350) • rifampicin
    8d
    A Phase 1 Study to Examine the Effects of Itraconazole After Single Dose Administration of Varegacestat (AL102) to Healthy Participants (clinicaltrials.gov)
    P1, N=22, Not yet recruiting, Immunome, Inc.
    New P1 trial
    |
    itraconazole • varegacestat (AL102)
    10d
    A Study to Assess the Effect of Itraconazole Capsules on the Pharmacokinetics of ZX-7101A Tablets in Healthy Adult Subjects in China (clinicaltrials.gov)
    P1, N=16, Completed, Nanjing Zenshine Pharmaceuticals | Not yet recruiting --> Completed
    Trial completion
    |
    itraconazole
    11d
    A Study to Investigate the Pharmacokinetics of AZD0780 When Administered Alone and in Combination With Itraconazole and Carbamazepine in Healthy Participants Aged 18 to 75 Years of Age (clinicaltrials.gov)
    P1, N=42, Recruiting, AstraZeneca
    New P1 trial • Combination therapy
    |
    itraconazole
    11d
    A Phase 1 Study in Healthy Volunteers to Evaluate the Drug-Drug Interaction Potential of Multiple Doses of ALG-000184. (clinicaltrials.gov)
    P1, N=24, Not yet recruiting, Aligos Therapeutics
    New P1 trial
    |
    itraconazole
    15d
    A Study in People With Advanced Cancer to Test Whether the Amount of BI 907828 in the Blood is Influenced by Taking an OATP Inhibitor or a CYP3 Inhibitor (clinicaltrials.gov)
    P1, N=34, Active, not recruiting, Boehringer Ingelheim | Trial completion date: Aug 2025 --> Feb 2025
    Trial completion date • Metastases
    |
    TP53 (Tumor protein P53)
    |
    TP53 wild-type
    |
    brigimadlin (BI 907828) • itraconazole • rifampicin
    17d
    Drug-Drug Interaction (DDI) Study for TQB3616 (clinicaltrials.gov)
    P1, N=40, Not yet recruiting, Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
    New P1 trial
    |
    culmerciclib (TQB3616) • itraconazole • rifampicin
    18d
    Study to Evaluate the Drug-drug Interaction of JMKX003142 in Healthy Subjects (clinicaltrials.gov)
    P1, N=48, Not yet recruiting, Jemincare
    New P1 trial
    |
    itraconazole • rifampicin
    30d
    MK-1708-008: A Study to Evaluate the Effects of Itraconazole on MK-1708 in Healthy Participants (MK-1708-003) (clinicaltrials.gov)
    P1, N=12, Recruiting, Merck Sharp & Dohme LLC | Not yet recruiting --> Recruiting
    Enrollment open
    |
    itraconazole
    1m
    A PK Study of IkT-148009 in Older and Elderly Healthy Subjects (clinicaltrials.gov)
    P1, N=8, Completed, Inhibikase Therapeutics, Inc.
    New P1 trial
    |
    itraconazole
    1m
    Itraconazole to Prevent Recurrent Barrett's Esophagus (clinicaltrials.gov)
    P1, N=10, Active, not recruiting, University of Kansas Medical Center | Recruiting --> Active, not recruiting | Trial completion date: Dec 2023 --> Jun 2025 | Trial primary completion date: Sep 2023 --> Feb 2024
    Enrollment closed • Trial completion date • Trial primary completion date
    |
    itraconazole
    1m
    A Study to Assess the Pharmacokinetics of AZD6793 When Administered Alone and in Combination With Itraconazole in Healthy Participants. (clinicaltrials.gov)
    P1, N=17, Completed, AstraZeneca | Active, not recruiting --> Completed
    Trial completion • Combination therapy
    |
    itraconazole
    1m
    A Study to Learn if the Study Medicines Called Itraconazole and Cyclosporine Change How the Body Processes the Other Study Medicine Called Danuglipron in Healthy Adults. (clinicaltrials.gov)
    P1, N=16, Not yet recruiting, Pfizer | Trial completion date: Oct 2024 --> Mar 2025 | Initiation date: Aug 2024 --> Dec 2024 | Trial primary completion date: Oct 2024 --> Mar 2025
    Trial completion date • Trial initiation date • Trial primary completion date
    |
    itraconazole • cyclosporine
    1m
    A Study to Evaluate the Effects of D-1553 on PK of Midazolam, Caffeine, Rosuvastatin, Furosemide, Digoxin, and Itraconazole or Omeprazole on PK of D-1553 (clinicaltrials.gov)
    P1, N=45, Completed, InventisBio Co., Ltd | Active, not recruiting --> Completed | Trial completion date: Jul 2024 --> Feb 2024
    Trial completion • Trial completion date
    |
    garsorasib (D-1553) • itraconazole • midazolam hydrochloride • omeprazole
    1m
    Early prediction and impact assessment of CYP3A4-related drug-drug interactions for small molecule anti-cancer drugs using human-CYP3A4-transgenic mouse models. (PubMed, Drug Metab Dispos)
    Victim drugs brigatinib and lorlatinib were evaluated with the new approach in combination with the perpetrator drugs itraconazole and rifampicin. The model was able to adequately describe the inhibition of CYP3A4 metabolism and the subsequent magnitude of change in exposure. However, it was unable to accurately predict the magnitude of change in exposure of victim drugs in combination with an inducer.
    Preclinical • Journal
    |
    CYP3A4 (Cytochrome P450, family 3, subfamily A, polypeptide 4)
    |
    Lorbrena (lorlatinib) • Alunbrig (brigatinib) • itraconazole • rifampicin
    1m
    A Clinical Trial to Evaluate the Effects of Itraconazole or Rifampicin on the Pharmacokinetics of VC004 Capsules in Healthy Adult Subjects (clinicaltrials.gov)
    P1, N=56, Not yet recruiting, Jiangsu vcare pharmaceutical technology co., LTD
    New P1 trial
    |
    itraconazole • VC004 • rifampicin
    2ms
    A Study to Evaluate the Effect of Cytochrome P450 (CYP) 3A Inhibitor (Itraconazole) and Inducer (Rifampin) on the Drug Levels of Golcadomide (BMS-986369) in Healthy Participants (clinicaltrials.gov)
    P1, N=35, Completed, Celgene | Recruiting --> Completed
    Trial completion
    |
    itraconazole • golcadomide (CC-99282) • rifampicin
    2ms
    A Study of Extending Relugolix Dosing Intervals Through Addition of Itraconazole or Ritonavir in Prostate Cancer Patients (clinicaltrials.gov)
    P1, N=60, Terminated, University of Chicago | N=100 --> 60 | Trial completion date: Apr 2025 --> Aug 2024 | Recruiting --> Terminated | Trial primary completion date: Apr 2025 --> Aug 2024; Terminated by the PI
    Enrollment change • Trial completion date • Trial termination • Trial primary completion date
    |
    itraconazole • Orgovyx (relugolix) • ritonavir
    2ms
    A Study to Assess Multiple Ascending Dose, Drug-Drug Interaction, and Asian Pharmacokinetic Study of ABBV-1088 (clinicaltrials.gov)
    P1, N=66, Recruiting, AbbVie | Not yet recruiting --> Recruiting
    Enrollment open
    |
    itraconazole
    2ms
    A Study in Healthy Volunteers to Evaluate the Safety, Tolerability, Pharmacokinetics, and Drug-Drug Interaction Potential of Single and Multiple Doses of ALG-097558 (clinicaltrials.gov)
    P1, N=144, Active, not recruiting, Aligos Therapeutics | Recruiting --> Active, not recruiting | Trial completion date: Jul 2024 --> Nov 2024
    Enrollment closed • Trial completion date
    |
    itraconazole • midazolam hydrochloride
    2ms
    A Study to Assess LY4100511 (DC-853) in Healthy Adult Participants (clinicaltrials.gov)
    P1, N=50, Active, not recruiting, DICE Therapeutics, Inc., a wholly owned subsidiary of Eli Lilly and Company | Recruiting --> Active, not recruiting | Trial completion date: Jun 2024 --> Dec 2024
    Enrollment closed • Trial completion date
    |
    itraconazole
    2ms
    To compare the efficacy and safety of low-dose venetoclax combined with azole and full-dose venetoclax without azole in the treatment of newly diagnosed AML patients who are intolerant to intensive chemotherapy (ChiCTR2400087406)
    P=N/A, N=60, Not yet recruiting, The First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital); Department of Hematology of Anhui Provinci
    New trial
    |
    Venclexta (venetoclax) • itraconazole • Noxafil (posaconazole)
    2ms
    A Study to Evaluate the Effect of Itraconazole on the Concentration of GSK3923868 in the Blood in Healthy Participants (clinicaltrials.gov)
    P1, N=20, Not yet recruiting, GlaxoSmithKline
    New P1 trial
    |
    itraconazole
    2ms
    A Study to Evaluate the Effects of Itraconazole on MK-1708 in Healthy Participants (MK-1708-008) (clinicaltrials.gov)
    P1, N=12, Not yet recruiting, Merck Sharp & Dohme LLC
    New P1 trial
    |
    itraconazole
    2ms
    A Drug-Drug Interaction (DDI) Study of ADC189 With Itraconazole in Healthy, Adult Subjects (clinicaltrials.gov)
    P1, N=16, Recruiting, Jiaxing AnDiCon Biotech Co.,Ltd
    New P1 trial
    |
    itraconazole
    2ms
    A Study to Assess the Pharmacokinetics of AZD6793 When Administered Alone and in Combination With Itraconazole in Healthy Participants. (clinicaltrials.gov)
    P1, N=8, Active, not recruiting, AstraZeneca | Recruiting --> Active, not recruiting | N=18 --> 8
    Enrollment closed • Enrollment change • Combination therapy
    |
    itraconazole
    2ms
    Pharmacokinetics of olverembatinib (HQP1351) in the presence of a strong CYP3A4 inhibitor (itraconazole) or inducer (rifampin) in healthy volunteers. (PubMed, Clin Transl Sci)
    Coadministration with rifampin decreased these same variables by 61.27%, 74.21%, and 75.19%, respectively. These results confirm that olverembatinib is primarily metabolized by CYP3A4 in humans, suggesting that caution should be exercised with concurrent use of olverembatinib and strong CYP3A4 inhibitors or inducers.
    PK/PD data • Journal
    |
    ABL1 (ABL proto-oncogene 1) • BCR (BCR Activator Of RhoGEF And GTPase)
    |
    ABL1 T315I
    |
    Nailike (olverembatinib) • itraconazole • rifampicin
    3ms
    A Study to Assess Multiple Ascending Dose, Drug-Drug Interaction, and Asian Pharmacokinetic Study of ABBV-1088 (clinicaltrials.gov)
    P1, N=66, Not yet recruiting, AbbVie
    New P1 trial
    |
    itraconazole
    3ms
    BGB-11417-107: A Study to Evaluate the Effects of Phenytoin and Itraconazole on Sonrotoclax (BGB-11417) in Healthy Volunteers (clinicaltrials.gov)
    P1, N=30, Recruiting, BeiGene | Not yet recruiting --> Recruiting
    Enrollment open
    |
    itraconazole • sonrotoclax (BGB-11417)
    3ms
    A Study to Assess the Pharmacokinetics of AZD6793 When Administered Alone and in Combination With Itraconazole in Healthy Participants. (clinicaltrials.gov)
    P1, N=18, Recruiting, AstraZeneca | N=48 --> 18
    Enrollment change • Combination therapy
    |
    itraconazole
    3ms
    A Drug-Drug Interaction (DDI) Study of HDM1002 With Rifampicin and Itraconazole in Healthy Subjects (clinicaltrials.gov)
    P1, N=40, Not yet recruiting, Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
    New P1 trial
    |
    itraconazole • rifampicin
    3ms
    Drug-Drug Interaction and Safety of AZD4041 Study (Part 1) and Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of AZD4041 Study in Opioid Use Disorder (Part 2). (clinicaltrials.gov)
    P2, N=100, Recruiting, AstraZeneca | Trial completion date: May 2026 --> Dec 2025 | Trial primary completion date: May 2026 --> Dec 2025
    Trial completion date • Trial primary completion date
    |
    itraconazole
    3ms
    A Study to Assess the Pharmacokinetics of AZD6793 When Administered Alone and in Combination With Itraconazole in Healthy Participants. (clinicaltrials.gov)
    P1, N=48, Recruiting, AstraZeneca | Not yet recruiting --> Recruiting | N=16 --> 48
    Enrollment open • Enrollment change • Combination therapy
    |
    itraconazole
    3ms
    A Clinical Trial to Evaluate the Effect of Itraconazole and Rifampicin on ABSK021 (clinicaltrials.gov)
    P1, N=32, Completed, Abbisko Therapeutics Co, Ltd | Enrolling by invitation --> Completed | Trial completion date: Nov 2023 --> Sep 2023
    Trial completion • Trial completion date
    |
    itraconazole • pimicotinib (ABSK021) • rifampicin
    3ms
    A Phase 1, Three-Part Open-Label Drug-Drug Interaction Study in Healthy participants to Determine the Effects of Itraconazole on the Pharmacokinetics of JNT-517 (Victim) and the Effects of JNT-517 (Perpetrator) on the Pharmacokinetics of Midazolam and Pravastatin (ACTRN12624000718549)
    P1, N=36, Completed, CTI Clinical Trial and Consulting Services Australia Pty Ltd | Recruiting --> Completed
    Trial completion
    |
    itraconazole • midazolam hydrochloride
    3ms
    A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors (clinicaltrials.gov)
    P1/2, N=766, Recruiting, DualityBio Inc. | Trial completion date: Oct 2025 --> Oct 2027 | Trial primary completion date: Jun 2025 --> Apr 2026
    Trial completion date • Trial primary completion date • Metastases
    |
    HER-2 (Human epidermal growth factor receptor 2)
    |
    Perjeta (pertuzumab) • BNT323 • itraconazole • ritonavir
    3ms
    A Study to Learn if the Study Medicines Called Itraconazole and Cyclosporine Change How the Body Processes the Other Study Medicine Called Danuglipron in Healthy Adults. (clinicaltrials.gov)
    P1, N=16, Not yet recruiting, Pfizer
    New P1 trial
    |
    itraconazole • cyclosporine
    3ms
    A Study to Evaluate the Effects of Phenytoin and Itraconazole on Sonrotoclax (BGB-11417) in Healthy Volunteers (clinicaltrials.gov)
    P1, N=30, Not yet recruiting, BeiGene
    New P1 trial
    |
    itraconazole • sonrotoclax (BGB-11417)