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    DRUG:

    itraconazole

    Company:
    Generic mfg.
    Drug class:
    CYP51A1 inhibitor
    Related drugs:
    4d
    A Study to Learn if a Medicine Called Itraconazole Changes How the Body Processes the Study Medicine PF-08642534 in Healthy Adults. (clinicaltrials.gov)
    P1, N=14, Not yet recruiting, Pfizer
    New P1 trial
    |
    itraconazole
    4d
    Histoplasmosis Induction and Consolidation Therapy Factorial Randomized Clinical Trial (Histo-FACT) (clinicaltrials.gov)
    P3, N=664, Not yet recruiting, University of Minnesota | Initiation date: May 2026 --> Sep 2026
    Trial initiation date
    |
    itraconazole • Noxafil (posaconazole)
    5d
    A Phase II Trial of Perioperative Oral Itraconazole for the Management of Low-Risk Basal Cell Carcinoma. (PubMed, Exp Dermatol)
    Coupled with the decrease in tumour size, a decrease in the expression of CD105, an endothelial marker (p < 0.0001), was observed. In conclusion, neoadjuvant itraconazole for 2 months was able to reduce the diameter of low-risk BCC, and the effect was associated with a decrease in tumour angiogenesis and a favourable safety profile.
    P2 data • Journal
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    ENG (Endoglin)
    |
    itraconazole
    8d
    Development of truncated-itraconazole analogues as potent Hedgehog/GLI pathway inhibitors and potential therapeutic agents for cutaneous squamous cell carcinoma. (PubMed, Eur J Med Chem)
    Preliminary safety evaluation revealed no significant hematological or organ toxicity. These results established truncated-ITZ analogues as promising HH/GLI pathway inhibitors and support further development of compound 16 as a potential therapeutic agent for cSCC.
    Journal
    |
    GLI1 (GLI Family Zinc Finger 1) • SOX2
    |
    itraconazole
    12d
    A Drug-Drug Interaction Study of Itraconazole and Opevesostat (MK-5684) in Healthy Adult Male Participants (MK-5684-017) (clinicaltrials.gov)
    P1, N=14, Recruiting, Merck Sharp & Dohme LLC | Not yet recruiting --> Recruiting
    Enrollment open
    |
    prednisone • itraconazole • opevesostat (MK-5684)
    12d
    Drug-drug Interaction Trial of AP31969 and Carbamazepine or Itraconazole (clinicaltrials.gov)
    P1, N=28, Active, not recruiting, Acesion Pharma | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    itraconazole
    13d
    LOXO-FRA-24001: A Study of LY4170156 in Participants With Selected Advanced Solid Tumors (clinicaltrials.gov)
    P1, N=495, Recruiting, Eli Lilly and Company | N=223 --> 495
    Enrollment change • First-in-human
    |
    Keytruda (pembrolizumab) • Avastin (bevacizumab) • carboplatin • itraconazole • sofetabart mipitecan (LY4170156)
    13d
    BNT326-01: A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors (clinicaltrials.gov)
    P1/2, N=980, Recruiting, BioNTech SE | N=329 --> 980
    Enrollment change • Trial initiation date
    |
    HER-2 (Human epidermal growth factor receptor 2) • BRAF (B-raf proto-oncogene) • ALK (Anaplastic lymphoma kinase)
    |
    PD-L1 expression • EGFR mutation • HR positive • BRAF mutation • HER-2 negative • EGFR L858R • HER-2 expression • EGFR exon 19 deletion • ALK rearrangement • PD-L1 expression + HER-2 overexpression • HER-2 negative + HR negative
    |
    itraconazole • pumitamig (BNT327) • BNT326
    15d
    A Single-center, Randomized, Open-label, Parallel-design Clinical Study to Evaluate the Pharmacokinetic Effects of Itraconazole, Fluconazole or Efavirenz on a Single Dose of Clifutinib in Healthy Participants (clinicaltrials.gov)
    P1, N=80, Not yet recruiting, Sunshine Lake Pharma Co., Ltd. | Trial completion date: May 2026 --> May 2027 | Initiation date: Mar 2026 --> Dec 2026 | Trial primary completion date: Apr 2026 --> Apr 2027
    Trial completion date • Trial initiation date • Trial primary completion date
    |
    clifutinib (HEC73543) • itraconazole • efavirenz
    16d
    MT-1-02: A PHASE?1, OPENLABEL, SINGLECENTER STUDY TO EVALUATE DRUGDRUG INTERACTIONS WITH GEMFIBROZIL, ITRACONAZOLE, AND CARBAMAZEPINE AND THE FOOD-EFFECT ON ORAL LERIGLITAZONE IN MALE HEALTHY SUBJECTS (2025-521508-23-00)
    P1, N=73, Active, not recruiting, Minoryx Therapeutics S.L. | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    itraconazole
    19d
    Drug-Drug Interaction Study of MDR-001 With Rifampin and Itraconazole in Healthy Adult Participants (clinicaltrials.gov)
    P1, N=28, Not yet recruiting, MindRank AI Ltd
    New P1 trial
    |
    itraconazole • rifampicin
    19d
    Drug-drug Interaction Trial of AP31969 and Carbamazepine or Itraconazole (clinicaltrials.gov)
    P1, N=28, Recruiting, Acesion Pharma | Not yet recruiting --> Recruiting
    Enrollment open
    |
    itraconazole