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    BIOMARKER:

    ITM2A overexpression

    i
    Other names: ITM2A, Integral Membrane Protein 2A, BRICD2A, E25A, BRICHOS Domain Containing 2A, Protein E25
    Entrez ID:
    9452
    3years
    Study on the Relationship between Integrin 2A and Drug Resistance in Chronic Myeloid Leukemia (PubMed, Zhongguo Shi Yan Xue Ye Xue Za Zhi)
    The expression of ITM2A was low in patients with drug resistance of CML, and the low expression of ITM2A may be the key factor of imatinib resistance in CML.
    Journal
    |
    ITM2A (Integral Membrane Protein 2A)
    |
    ITM2A overexpression
    |
    imatinib
    over3years
    Connecting Genetic Heterogeneity with Single-Cell Transcriptome Dysregulations in Pediatric Acute Myeloid Leukemia (ASH 2022)
    In this study, the hypothesis that mutation-associated transcriptional profiles drive different outcomes in pediatric AML was investigated at the single cell level. We found genetic subtype-specific transcriptome differences in AML-blasts as well as differences in T cells might be contributing toward diverse clinical outcomes.
    Clinical
    |
    RUNX1 (RUNX Family Transcription Factor 1) • KMT2A (Lysine Methyltransferase 2A) • RUNX1T1 (RUNX1 Partner Transcriptional Co-Repressor 1) • CEBPA (CCAAT Enhancer Binding Protein Alpha) • ITM2A (Integral Membrane Protein 2A) • SOCS2 (Suppressor Of Cytokine Signaling 2)
    |
    MLL rearrangement • MLL rearrangement • KMT2A expression • Chr del(7q) • ITM2A overexpression
    4years
    Integral membrane protein 2A enhances sensitivity to chemotherapy via notch signaling pathway in cervical cancer. (PubMed, Bioengineered)
    Mechanically, ITM2A upregulation mediates the sensitivity of cervical cancer cell through Notch signaling pathway. Our study suggests that ITM2A may serve as a target in mediating cisplatin-resistant cervical cancer.
    Journal
    |
    ITM2A (Integral Membrane Protein 2A)
    |
    ITM2A overexpression
    |
    cisplatin