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DRUG:

ITI-1001

i
Other names: ITI-1001, ITI1001, ITI 1001
Associations
Company:
HLB Bio Group
Drug class:
Immunostimulant
Related drugs:
Associations
8ms
Study to Evaluate the Safety, Tolerability, Immunogenicity and Preliminary Efficacy of ITI-1001 In Patients With Newly Diagnosed Glioblastoma (GBM) (clinicaltrials.gov)
P1, N=10, Active, not recruiting, Immunomic Therapeutics, Inc. | Trial primary completion date: Jun 2025 --> Mar 2026 | Recruiting --> Active, not recruiting
Enrollment closed • Trial primary completion date
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CD8 (cluster of differentiation 8) • CD163 (CD163 Molecule) • FOXP3 (Forkhead Box P3)
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ITI-1001
11ms
Trial completion date • Trial primary completion date
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CD8 (cluster of differentiation 8) • CD163 (CD163 Molecule) • FOXP3 (Forkhead Box P3)
|
ITI-1001
over2years
Development and Characterization of an HCMV Multi-Antigen Therapeutic Vaccine for Glioblastoma Using the UNITE Platform. (PubMed, Front Oncol)
Further characterization of these two groups showed high infiltration of CD3+, CD4+, and CD8+ T cells in responders compared to non-responders. Thus, we show that vaccination with HCMV antigens using the ITI-1001-UNITE platform generates strong cellular and humoral immune responses, triggering significant antitumor activity, leading to enhanced survival in a mouse model of GBM.
Journal
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CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • CD4 (CD4 Molecule) • LAMP1 (Lysosomal Associated Membrane Protein 1)
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ITI-1001