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GENE:

ITGB1 (Integrin Subunit Beta 1)

News alerts, weekly reports and conference planners

A longitudinal, multi-omic atlas reveals the emergence of a spatially organized immunosuppressive ecosystem in resistant melanoma. (PubMed, Cell Rep Med)

Validated across independent cohorts, these spatial and molecular signatures predict poor survival and point to actionable targets. Ultimately, our study elucidates the spatial logic of resistance and provides a rationale for translating multi-omic discoveries into actionable, personalized therapeutic strategies.

8 days ago

Journal

CD276 (CD276 Molecule) • IDO1 (Indoleamine 2,3-dioxygenase 1) • GDF15 (Growth differentiation factor 15) • MITF (Melanocyte Inducing Transcription Factor) • ITGB1 (Integrin Subunit Beta 1)

FBXO6 regulates colon cancer migration and invasion via ITGB1 ubiquitination and downstream signaling. (PubMed, Cell Death Dis)

Additional rescue experiments show that FBXO6 counteracts the tumor-promoting effects of ITGB1 overexpression. In conclusion, FBXO6 suppresses CRC cell proliferation, migration, and invasion by targeting ITGB1 for ubiquitination and disrupting key oncogenic signaling pathways, thereby supporting its potential as a prognostic biomarker and candidate therapeutic target in CRC.

8 days ago

Journal

ITGB1 (Integrin Subunit Beta 1)

11d

Complex aberrant expression of planar nuclear polarity factors in intraductal papillary mucinous neoplasm of the pancreas. (PubMed, Virchows Arch)

Overall, our study indicates that the molecular mechanisms underlying disturbed PNP in IPMNs are not mediated by a single pathway but involve multiple interconnected pathways. Our findings may contribute to elucidation of the molecular mechanisms regulating PNP in IPMNs, enhancing our understanding of tumor progression and contributing to more accurate pathological diagnosis.

11 days ago

Journal

TOP2A (DNA topoisomerase 2-alpha) • MAPK1 (Mitogen-activated protein kinase 1) • RHOA (Ras homolog family member A) • TWIST1 (Twist Family BHLH Transcription Factor 1) • ANO1 (Anoctamin 1) • CDC42 (Cell Division Cycle 42) • FSCN1 (Fascin Actin-Bundling Protein 1) • LATS2 (Large Tumor Suppressor Kinase 2) • CLDN7 (Claudin 7) • ITGB1 (Integrin Subunit Beta 1) • TGFBR1 (Transforming Growth Factor Beta Receptor 1)

12d

Loss of WT1 Drives Adaptive Plasticity in CCDC6-RET Selpercatinib-Resistant Papillary Thyroid Cancer. (PubMed, Curr Issues Mol Biol)

These molecular changes were associated with higher cell motility of TPC-1-SelpRWT1-knockdown. Collectively, these findings suggest that WT1 is a critical regulator involved in tumor plasticity, thereby supporting selpercatinib resistance.

12 days ago

Journal

RET (Ret Proto-Oncogene) • CCDC6 (Coiled-Coil Domain Containing 6) • WT1 (WT1 Transcription Factor) • SOX2 • VIM (Vimentin) • SOX17 (SRY-Box Transcription Factor 17) • ITGB1 (Integrin Subunit Beta 1)

Retevmo (selpercatinib)

14d

Non-telomeric function deficiency of TERT enhances pressure overload-induced mouse cardiac remodeling by activation of CNBP-mediated THBS3/ITGB1 pathway. (PubMed, Acta Pharmacol Sin)

TERT knockdown greatly enhanced, while TERT overexpression inhibited the activation of the THBS3/ITGB1 signaling pathway, in which transcription factor cellular nucleic acid-binding protein (CNBP) played a pivotal mediating role by interacting with TERT. In conclusion, the non-telomeric function of TERT in gene transcription regulation and signaling transduction plays an important role during pressure overload-induced myocardial remodeling via modulating CNBP-mediated THBS3/ITGB1 signaling pathway, which provides new targets and strategies for the prevention and treatment of pressure overload-induced cardiac remodeling.

14 days ago

Preclinical • Journal

TERT (Telomerase Reverse Transcriptase) • ITGB1 (Integrin Subunit Beta 1)

15d

Endothelial SMAD1-MCAM axis facilitates sunitinib resistance and progression of clear cell renal cell carcinoma via LAMB1-ITGB1 signaling. (PubMed, Drug Resist Updat)

This model effectively stratified patients by overall survival and metastatic risk, demonstrating superior prognostic accuracy compared to standard clinicopathological features. Collectively, our study elucidates a critical tumor-stroma crosstalk mechanism governed by the SMAD1-MCAM-LAMB1-ITGB1-RhoA axis, providing novel mechanistic insights into the metastatic process and identifying potential candidates for therapeutic intervention in ccRCC.

15 days ago

Journal

RHOA (Ras homolog family member A) • MCAM (Melanoma Cell Adhesion Molecule) • ITGB1 (Integrin Subunit Beta 1) • LAMB1 (Laminin Subunit Beta 1)

sunitinib

22d

Longitudinal analysis of peripheral blood immune status and prognosis dynamic prediction for advanced colon cancer with first-line chemotherapy. (PubMed, Cancer Immunol Immunother)

This study highlights the prognostic significance of measuring longitudinal immune status in advanced CRC patients and develops an internally validated dynamic prediction model. External validation is needed before clinical implementation.

22 days ago

Retrospective data • Journal

IL6 (Interleukin 6) • CA 19-9 (Cancer antigen 19-9) • ITGB1 (Integrin Subunit Beta 1)

27d

Dynamic integrin expression, atypical nuclear localization, and spatial distribution during ovarian cancer progression and metastasis. (PubMed, Front Cell Dev Biol)

The coordinated upregulation of integrins, other adhesion molecules (CD44, NCAM1, VCAM), ECM (FN1, collagens) and their regulators (SPP1, TIMP2,3) in response to the culture conditions indicate a complex reprogramming of adhesion networks that can facilitate different steps of ovarian cancer progression and dissemination. Nuclear localization of integrins and CD44 point to dual roles in adhesion, survival, and proliferation by activating adhesion-mediated signaling pathways and directly affect gene transcription that support a switch from a more dormant phenotype to active proliferation and invasion after adhesion.

27 days ago

Journal

SPP1 (Secreted Phosphoprotein 1) • NCAM1 (Neural cell adhesion molecule 1) • TIMP2 (TIMP Metallopeptidase Inhibitor 2) • ITGA4 (Integrin, alpha 4) • ITGA5 (Integrin Subunit Alpha 5) • ITGB1 (Integrin Subunit Beta 1)

CD19+Ki67+B cells regulated by NAMPT as key modulators in triple-negative breast cancer with brain metastasis. (PubMed, Breast Cancer Res)

CD19+Ki67+ B cells drive TNBC progression and brain metastasis by activating the NAMPT/ITGA5/ITGB1 pathway. These findings provide mechanistic insights into the immune regulation of TNBC BrM and identify potential therapeutic targets to improve clinical outcomes.

1 month ago

Journal

NAMPT (Nicotinamide Phosphoribosyltransferase) • ITGA5 (Integrin Subunit Alpha 5) • ITGB1 (Integrin Subunit Beta 1)

ODC1 Polyamine Metabolism Drives Prostate Cancer via AKT and Splicing. (PubMed, J Cell Mol Med)

These results indicate that ODC1 influences prostate cancer cell behaviour by regulating both gene expression and splicing, particularly affecting pathways involved in angiogenesis, adhesion, and the cell cycle. This points to the AKT pathway and polyamine metabolism as potentially valuable targets for future prostate cancer therapies.

1 month ago

Journal

CAV1 (Caveolin 1) • ITGB1 (Integrin Subunit Beta 1) • ODC1 (Ornithine Decarboxylase 1) • YTHDF2 (YTH N6-Methyladenosine RNA Binding Protein 2)

COL8A1-positive cancer-associated fibroblasts are drivers of 5-fluorouracil resistance in colorectal cancer. (PubMed, Apoptosis)

COL8A1⁺Fibs orchestrate 5-FU resistance in CRC via a COL8A1/ITGB1-mediated EMT axis. Disrupting this stromal-tumor crosstalk represents a promising therapeutic strategy to overcome chemoresistance.

1 month ago

Journal

COL8A1 (Collagen Type VIII Alpha 1 Chain) • ITGB1 (Integrin Subunit Beta 1)

5-fluorouracil

Interleukin-30 promotes melanoma spreading and triggers LAG-3 expression and T cell exhaustion. (PubMed, Biomed Pharmacother)

Concurrently, IL30 suppresses T cell function by reducing CD25 and HLA-DR expression on CD4⁺ and CD8⁺ T cells, inhibiting their activation and proliferation, decreasing TNF-α and IFN-γ production, and boosting LAG-3 expression, which strongly correlates with IL30 levels in clinical samples. Collectively, these findings identify IL30 as a critical driver of melanoma dissemination and T cell exhaustion, providing a mechanistic link to immune resistance and failure of combination immunotherapies.

1 month ago

Journal • PD(L)-1 Biomarker • IO biomarker

CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • IFNG (Interferon, gamma) • LAG3 (Lymphocyte Activating 3) • CD276 (CD276 Molecule) • TNFA (Tumor Necrosis Factor-Alpha) • VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • IL2RA (Interleukin 2 receptor, alpha) • CD4 (CD4 Molecule) • MMP2 (Matrix metallopeptidase 2) • VEGFC (Vascular Endothelial Growth Factor C) • LGALS3 (Galectin 3) • L1CAM (L1 cell adhesion molecule) • SNAI2 (Snail Family Transcriptional Repressor 2) • ITGB1 (Integrin Subunit Beta 1) • LGALS9 (Galectin 9)