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GENE:

ITGB1 (Integrin Subunit Beta 1)

News alerts, weekly reports and conference planners

Adipocyte-derived FABP4 promotes metabolism-associated steatotic liver-induced hepatocellular carcinoma by driving ITGB1-mediated β-catenin activation. (PubMed, J Clin Invest)

We developed an anti-FABP4 neutralizing antibody that successfully inhibited FABP4-driven CSC functions and suppressed MASLD-induced HCC. In conclusion, our findings indicate that adipocyte-derived FABP4 plays a critical role in the development of MASLD-induced HCC and targeting the ITGB1/PI3K/AKT/β-catenin signaling cascade may offer a promising approach to combat this aggressive disease.

3 days ago

Journal

FABP4 (Fatty Acid Binding Protein 4) • ITGB1 (Integrin Subunit Beta 1)

Rotating magnetic field downregulating type XI collagen to suppress triple-negative breast cancer metastasis by inactivating the ITGB1/FAK/YAP signaling pathway. (PubMed, Int J Biol Macromol)

Moreover, the therapeutic effect was further enhanced by combining RMF and COL11A1 siRNA. These findings suggested COL11A1 as a potential TNBC therapeutic target, with COL11A1 siRNA combined with RMF offering a viable treatment strategy.

4 days ago

Journal

COL1A1 (Collagen Type I Alpha 1 Chain) • COL11A1 (Collagen Type XI Alpha 1 Chain) • ITGB1 (Integrin Subunit Beta 1)

ALKBH5-Mediated ITGB1 m6A Modification in Ovarian Cancer Progression and Immune Evasion. (PubMed, NPJ Precis Oncol)

Mechanistically, ALKBH5 binds to ITGB1 mRNA and removes m6A modifications, increasing its stability and expression. Targeting the ALKBH5-ITGB1 axis may offer novel diagnostic biomarkers and therapeutic strategies for OC.

9 days ago

Journal

ALKBH5 (AlkB Homolog 5, RNA Demethylase) • ITGB1 (Integrin Subunit Beta 1)

Exploratory study on the role of Clonorchis sinensis infection in promoting cholangiocarcinoma progression. (PubMed, Parasit Vectors)

C. sinensis can effectively promote the pathogenesis of CCA and significantly increase the expression of CCA-related genes (e.g., CK19 and CK7). The inflammation, disrupting circadian rhythms and altering energy metabolism caused by C. sinensis infection, may promote the progression of CCA. This study provides a foundational experimental basis for diagnosing and intervening in C. sinensis-related CCA.

9 days ago

Journal

TP53 (Tumor protein P53) • MMP2 (Matrix metallopeptidase 2) • KRT19 (Keratin 19) • PCNA (Proliferating cell nuclear antigen) • ITGB1 (Integrin Subunit Beta 1)

13d

MicroRNA-124-3p suppresses lung cancer by targeting ITGB1/PI3K/p-AKT signal transduction pathway. (PubMed, Exp Cell Res)

Consistent with this, bioinformatics analysis demonstrated that miR-124-3p expression is significantly lower in tumor tissues than in adjacent normal lung and further decreases in advanced T stage (T3-T4) compared to early stage (T1-T2). These findings indicate that miR-124-3p inhibits NSCLC progression via the ITGB1/PI3K/p-AKT axis and remains functional despite PIK3CA activation, supporting its potential as a therapeutic candidate.

13 days ago

Journal

PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • ITGB1 (Integrin Subunit Beta 1) • MIR124-3 (MicroRNA 124-3)

PIK3CA mutation

17d

Network Pharmacology and In Vitro Cell Experimental Study for Exploring the Therapeutic Potential of Thiazolone Derivatives in Rhabdomyosarcoma. (PubMed, J Vis Exp)

The results of in vitro cell culture experiments showed that a specific thiazolone derivative had a significant inhibitory effect on RD cell lines, providing a scientific basis for the discovery of new targets and effective compounds for the treatment of RD. This study revealed the mechanisms of thiazolone derivatives in the treatment of RD through a combination of network pharmacology and in vitro experiments and provided a new perspective for future drug development and treatment strategies.

17 days ago

Preclinical • Journal

AKT1 (V-akt murine thymoma viral oncogene homolog 1) • PIK3CD (Phosphatidylinositol-4 5-Bisphosphate 3-Kinase Catalytic Subunit Delta) • HSP90AB1 (Heat Shock Protein 90 Alpha Family Class B Member 1) • ITGB1 (Integrin Subunit Beta 1)

18d

Molecular Resonance Quantification and Label-Free Interactome Characterization of Total Proteome of Tumor Specimens Decipher Responder and Success Predictors in Colorectal Cancer Patients Treated With Panitumumab. (PubMed, Cancer Med)

Combination of PIMS and NPOT coupled to label-free quantitative proteomics point towards the distinct panitumumab mode of action in CRC patients and highlights specific proteins as prognostic biomarkers which need further validation in a bigger cohort and multicentric investigation, ideally involving patient registry follow up data.

18 days ago

Journal

CTNNB1 (Catenin (cadherin-associated protein), beta 1) • POLD1 (DNA Polymerase Delta 1) • PTPN1 (Protein Tyrosine Phosphatase Non-Receptor Type 1) • ENO1 (Enolase 1) • YBX1 (Y-Box Binding Protein 1) • CTNND1 (Catenin Delta 1) • ITGB2 (Integrin Subunit Beta 2) • LRIG1 (Leucine Rich Repeats And Immunoglobulin Like Domains 1) • NT5C (5', 3'-Nucleotidase, Cytosolic) • PRKDC (Protein Kinase, DNA-Activated, Catalytic Subunit) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1) • HSP90AB1 (Heat Shock Protein 90 Alpha Family Class B Member 1) • HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4) • ITGB1 (Integrin Subunit Beta 1) • PPM1G (Protein Phosphatase, Mg2+/Mn2+ Dependent 1G) • YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta) • HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8) • NCAPD2 (Non-SMC Condensin I Complex Subunit D2)

Vectibix (panitumumab)

19d

Unveiling the ITGβ1-CLIC1 axis: a new frontier in oral squamous cell carcinoma progression and immune evasion: insights from the tumor-mimetic ECM system. (PubMed, BMC Cancer)

This study provides evidence supporting the association between the ITGβ1-CLIC1 axis and OSCC progression, and suggests its potential involvement in modulating the tumor immune microenvironment, indicating its promise as a therapeutic target worthy of further investigation.

19 days ago

Journal

CLIC1 (Chloride Intracellular Channel 1) • ITGB1 (Integrin Subunit Beta 1)

21d

Molecular Basis of Simalikalactone D Sensitivity in Triple-Negative Breast Cancer Cells. (PubMed, Biomolecules)

In silico docking confirmed favorable binding affinities of SKD to both EGFR (ΔG = -6.718 kcal/mol) and STAT4 (ΔG = -8.481 kcal/mol). Overall, our findings suggest that SKD is a potent anticancer agent in a subgroup of TNBC cells.

21 days ago

Journal • PARP Biomarker • IO biomarker

EGFR (Epidermal growth factor receptor) • BCL2 (B-cell CLL/lymphoma 2) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • BIRC5 (Baculoviral IAP repeat containing 5) • CASP3 (Caspase 3) • DAXX (Death-domain associated protein) • ITGB1 (Integrin Subunit Beta 1) • STAT4 (Signal Transducer And Activator Of Transcription 4)

22d

Endothelial cells sense temozolomide resistance to facilitate monocyte-derived macrophage infiltration in glioblastoma. (PubMed, Drug Resist Updat)

This study identifies a novel signaling cascade whereby TMZ-resistant GBM secretes COL6A1 to activate an IKZF1-UBD axis in ECs, disrupting blood vessel integrity and facilitating MDM infiltration. Our findings delineate the pivotal mechanism by which tumor cells engage ECs to drive MDM infiltration - a linchpin part of the positive-feedback loop that couples TMZ resistance to MDM influx. Targeting IKZF1 with LEN represents a promising strategy for restoring endothelial barrier function, reducing MDM infiltration, and enhancing chemosensitivity in GBM.

22 days ago

Journal

IKZF1 (IKAROS Family Zinc Finger 1) • CHD1 (Chromodomain Helicase DNA Binding Protein 1) • COL6A1 (Collagen Type VI Alpha 1 Chain) • CLDN5 (Claudin 5) • ITGB1 (Integrin Subunit Beta 1)

lenalidomide • temozolomide

22d

MicroRNA Signatures in Serous Ovarian Cancer: A Comparison of Prognostic Marker Targets in African Americans and Caucasians. (PubMed, Diseases)

Pathway enrichment and gene ontology analyses (miRTargetLink2.0, Enrichr) revealed interconnected regulatory networks linking miR-192, miR-16-5p, miR-143-3p, and miR-20a-5p to ITGB1; miR-143-3p/miR-145-5p to BRAF; and miR-16-5p and miR-30c/d to TIMP3. Collectively, these findings identify distinct miRNA-mRNA regulatory signatures-particularly the miR-192-5p-ITGB1/TIMP3 axis-as potential clinically relevant biomarkers that may contribute to racial disparities and disease progression in ovarian cancer.

22 days ago

Journal

BRAF (B-raf proto-oncogene) • MIR192 (MicroRNA 192) • MIR143 (MicroRNA 143) • MIR16 (MicroRNA 16) • MIR30D (MicroRNA 30d) • ITGB1 (Integrin Subunit Beta 1) • MIR145 (MicroRNA 145) • MIR20A (MicroRNA 20a) • MIR30C • TIMP3 (TIMP Metallopeptidase Inhibitor 3)

26d

Laminin β1 stimulates the Hippo-YAP1 pathway to advance the progression and lenvatinib resistance in hepatocellular carcinoma. (PubMed, Int J Biol Macromol)

Additionally, serum LAMB1 demonstrates superior diagnostic performance compared to the classic HCC marker alpha-fetoprotein. LAMB1 represents a promising therapeutic target for HCC, and also serves as a potential circulating biomarker for liver cancer screening in clinics.

26 days ago

Journal

AFP (Alpha-fetoprotein) • YAP1 (Yes associated protein 1) • ITGB1 (Integrin Subunit Beta 1) • LAMB1 (Laminin Subunit Beta 1) • TEAD4 (TEA Domain Transcription Factor 4)

Lenvima (lenvatinib)