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    BIOMARKER:

    ITGAE overexpression

    i
    Other names: Integrin Subunit Alpha E, Integrin, Alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1; Alpha Polypeptide), Human Mucosal Lymphocyte Antigen 1, Alpha Polypeptide, Mucosal Lymphocyte 1 Antigen, Integrin Alpha-IEL, Integrin Alpha-E, HML-1 Antigen, HUMINAE, CD103, Antigen CD103, Human Mucosal Lymphocyte Antigen 1; Alpha Polypeptide, Antigen CD103, CD103 Antigen, ITGAE
    Entrez ID:
    3682
    1m
    Immune microenvironment of Epstein-Barr virus (EBV)-negative compared to EBV-associated gastric cancers: implications for immunotherapy. (PubMed, J Immunother Cancer)
    While certain markers of immunosuppression are found in the GC TiME regardless of EBV status, EBV(-) GCs, which are much more common than EBV+ GCs, overexpress components of the COX-2/PGE2 pathway. These findings provide novel insights into the immune microenvironments of EBV+ and EBV(-) GC, and offer potential targets to overcome resistance to anti-PD-(L)1 therapies.
    Clinical • Journal • PD(L)-1 Biomarker • IO biomarker
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    CD8 (cluster of differentiation 8) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • CD73 (5'-Nucleotidase Ecto) • PD-L2 (Programmed Cell Death 1 Ligand 2) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • CD163 (CD163 Molecule) • IDO1 (Indoleamine 2,3-dioxygenase 1) • CXCL9 (Chemokine (C-X-C motif) ligand 9) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • IL10 (Interleukin 10) • NT5E (5'-Nucleotidase Ecto) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • IL1A (Interleukin 1, alpha) • IL32 (Interleukin 32) • ITGAE (Integrin Subunit Alpha E) • ENTPD1 (Ectonucleoside Triphosphate Diphosphohydrolase 1) • IL1B (Interleukin 1, beta) • NOS2 (Nitric Oxide Synthase 2) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA) • PTGER4 (Prostaglandin E Receptor 4) • VSIR (V-Set Immunoregulatory Receptor)
    |
    ITGAE overexpression
    2years
    The Abundance of Tumor-Infiltrating CD8 Tissue Resident Memory T Lymphocytes Correlates with Patient Survival in Glioblastoma. (PubMed, Biomedicines)
    This analysis also highlighted the positive correlation between genes associated with CD8 TRM and TILs, indicating that CD8 TRMs cells are present among the infiltrating T cells. Finally, high expression of Integrin subunit alpha E (ITGAE), the gene coding for the integrin CD103, and high CD8 TILs abundance were associated with more prolonged survival, whereas high ITGAE expression but low CD8 TILs abundance were associated with lower survival.
    Journal
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    CD8 (cluster of differentiation 8) • CD69 (CD69 Molecule) • ITGAE (Integrin Subunit Alpha E)
    |
    CD8 expression • CD8-H • ITGAE overexpression
    over2years
    CD103 T Cells May Be a Useful Biomarker in Borrmann Type 4 Gastric Cancer. (PubMed, Cancer Diagn Progn)
    CD103 T cells may be a prognostic marker in type 4 GC.
    Journal
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    ITGAE (Integrin Subunit Alpha E)
    |
    ITGAE overexpression