ITGA7 (Integrin Subunit Alpha 7)

Specifically, CAFs exhibited significantly higher expression levels of COL7A1 compared to normal pancreatic fibroblasts, and COL7A1 knockdown in CAFs markedly reduced the migratory capacity of PC cells while enhancing their chemosensitivity to gemcitabine...This model, incorporating pivotal genes of PCLM and BM, may also serve as potential tool for predicting the tumor immune microenvironment and therapeutic efficacy. Notably, COL7A1, which was demonstrated to be vital in PC metastasis in this study, warrants further investigation in future research.

Our findings demonstrate the potential of ITGA7-targeted LCMSNs as a PAI-1 siRNA delivery system to therapeutically target ASC-mediated oncogenesis in the endometrial tumor microenvironment. Future studies will evaluate the efficacy of PAI-1 silencing in inhibiting obesity-driven endometrial cancer growth, using in vivo models.

These findings demonstrate that surface biotinylation improves the sensitivity and selectivity of plasma membrane proteomics under hypoxia, revealing hypoxia-responsive proteins and pathways not captured by standard whole-cell analysis.

Integrin α7 has been a therapeutic target in tumors, and antibody-based integrin α7 neutralization can be clinically useful. The results of this study suggest implications for integrin α7 and laminin-α2 chains in DC immunotherapy.

The reprogramming efficiency of cells induced on the E8 fragment of laminin-511 (eiPSC-511) was higher than that on Geltrex containing laminin-111 as a major laminin (eiPSC-111), and supplementation with a cocktail of small molecular compounds increased the number of iPSC colonies on both substrates...On the contrary, although no significant differences were observed in the histology of teratomas, increased in vitro differentiation into three germ layers in eiPSC-111 was shown compared to those in eiPSC-511. Thus, these results contributed to the improved generation of iPSC in horses.

Finally, we performed in vitro cellular experiments on the integrin family gene ITGA7 and demonstrated that ITGA7 can serve as a biomarker for gliomas. Our findings provide important insights into the multifaceted roles of integrins in glioma biology, provide an opportunity for the discovery of novel targeted therapies on the basis of the subtype-specific vulnerability of integrins, and provide a basis for the study of the role of ITGA7 in gliomas.

Additionally, integrin co-expression networks in healthy and cancerous breast tissues were compared and were found to change significantly from healthy to cancer, indicating changes in functional involvement of integrins due to cancer. Integrin expression in metastatic tumors were further examined using data from the AURORA project for Metastatic Breast Cancer (MBC), and several integrins such as ITGAD, ITGA4, ITGAL, and ITGA11 were found to have significantly lower expression in metastases than in primary tumors.

"Finally, consistent with DNA hypomethylation reflecting the proliferative history of MM, the PR subtype had the most pronounced DNA hypomethylation. Notably, the PR subtype had reduced DNAm at E2F1 motifs and E2F1 exclusively bound unmethylated regions of the genome, suggesting the DNAm restricts the proliferative program of high-risk MM."

Integrin expression patterns vary widely across tissues and are greatly impacted by cancer. Machine learning of these patterns can effectively distinguish samples by tissue or disease status.

This pan-cancer study found that abnormal expression of ITGA7 was correlated with poor prognosis and metastasis in different types of tumors. Thus, the ITGA7 gene may prove to be a promising biomarker for the prognosis and complication prevention of different cancers.

Lastly, the prognostic nomogram model based on the risk score was found to be effective in identifying high-risk patients and predicting OS. A basement membrane-related risk signature was constructed and found to be effective for predicting the prognosis of patients with CRC.