ITGA6 (Integrin, alpha 6)

In keratinocytes, BMRGs such as integrins (ITGB1, ITGA3, ITGA6), laminins (LAMA3, LAMC1), CD44, and FN1 were upregulated in cSCC compared to AK or BD (adjusted p < 0.05); in fibroblasts, BMRGs including ITGB1, ITGAV, LUM, BGN, SDC1, and FN1 were upregulated in cSCC (adjusted p < 0.05), suggesting their collective role in BM breaching and invasion, as well as a higher risk of BD. This study provides novel biological insights into the differentiation of progression pathways from AK or BD to cSCC, as well as potential targets for therapeutic intervention.

Disruption of LAMA4-ITGA6 binding substantially attenuated FOXC2-LAMA4-mediated metastatic burden. These results reveal a novel mechanism by which FOXC2+ tumor cells promote metastasis in advanced ccRCC and further establish the therapeutic potential of targeting FOXC2-LAMA4 in blocking the metastatic cascade of ccRCC.

Furthermore, risk models incorporating specific protein signatures effectively stratified patients by platinum sensitivity/resistance (9-protein panel: ILK, CDCP1, CD86, CLDN4, CLEC1B, CDHR5, CLDN11, JAM2, FOLH1), lymph node metastasis status (7-protein panel: APOE, CD28, CLDN4, FOLH1, ITGAL, JAML, ULBP3), and post-surgical residual disease burden (4-protein panel: CD44, CLMP, ITGA4, AMIGO1), with Cluster 13 (ITGB1-high) also significantly associated with residual disease. This work demonstrates the power of single-EV proteomics combined with machine learning for non-invasive diagnosis and clinical outcome assessment in advanced ovarian cancer, though the absence of early-stage patients limits its applicability for early detection.

Finally, hMSCs expanded on S75H25 were successfully differentiated into adipogenic, chondrogenic, and osteogenic cell types. We engineered chemically defined and highly economical GAG-mimetic cell culture substrates based on sulfonated polymer brushes that can be readily applied to biomanufacturing platforms such as spinner flasks, bioreactor beads, and microfluidic platforms to boost hMSC throughput under fully defined conditions.

CD97, CD73, CD86, and CD58 are the best amongst newer markers in B-ALL MRD assessment. Our findings support integrating these into MRD panels to enhance post-therapy MRD detection, thus improving prognostication and guiding treatment decisions.

We found that csPCNA is co-expressed with CD44, CD49f, PD-L1, and TGFβRII on the primary patient-derived GBM specimen. Our findings that csPCNA is expressed in GBM and is co-expressed with stem cell and immunosuppressive biomarkers indicate that csPCNA may be a potentially useful clinical-pathological biomarker for GBM stemness and immunosuppression.

Based on our results, the CD49f molecule can be used as a measurable residual disease marker in both pediatric and adult B-cell acute lymphoblastic leukemia patient groups, and its expression correlates with genetic abnormalities and focal adhesion kinase-Src pathway activation. Orv Hetil. 2025; 166(50): 1983-1992.

The GPSICCA score was positively correlated with stromal and immune scores, suggesting its predictive capability is related to TME involvement in ICCA. The GPSICCA model is a strong predictor of survival in ICCA patients and could help guide treatment strategies and identify potential therapeutic targets.

The clinical relevance of these findings is underscored by increased EV biogenesis in LAM patients and the enrichment of these EV cargo with lung-tropic integrins and metalloproteinases. These findings establish EVs as a novel therapeutic target in LAM, warranting future clinical studies.

Our findings provide a comprehensive cellular atlas of CSCC, highlighting the association of CAFs in HPV infection and tumor progression of CSCC. These results also offer potential diagnostic and prognostic biomarkers for CSCC patients.

Specifically, CAFs exhibited significantly higher expression levels of COL7A1 compared to normal pancreatic fibroblasts, and COL7A1 knockdown in CAFs markedly reduced the migratory capacity of PC cells while enhancing their chemosensitivity to gemcitabine...This model, incorporating pivotal genes of PCLM and BM, may also serve as potential tool for predicting the tumor immune microenvironment and therapeutic efficacy. Notably, COL7A1, which was demonstrated to be vital in PC metastasis in this study, warrants further investigation in future research.

Altogether, our results suggest that ITGA6 X1X2 could be a rare, tightly regulated isoform with potential functional and pathological relevance.