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    GENE:

    ITGA5 (Integrin Subunit Alpha 5)

    i
    Other names: ITGA5, Integrin Subunit Alpha 5, CD49e, FNRA, Integrin, Alpha 5 (Fibronectin Receptor, Alpha Polypeptide), Fibronectin Receptor, Alpha Polypeptide, Fibronectin Receptor Subunit Alpha, CD49 Antigen-Like Family Member E, Integrin Alpha-5, Integrin Alpha-F, VLA-5, Very Late Activation Protein 5, Alpha Subunit, Fibronectin Receptor, Alpha Subunit, ITGA5/SLC9B1 Fusion, CD49e Antigen, VLA5A
    Associations

    News

    Trials
    4d
    PLA-THF-PEG nanoparticles Co-encapsulating AV3 and KH3 for synergistic pancreatic cancer therapy via stromal remodeling and metabolic inhibition. (PubMed, Front Pharmacol)
    These findings demonstrate that pH-sensitive AKNPs integrate stromal remodeling and metabolic inhibition to synergistically suppress PDAC progression. This nanoplatform provides a promising therapeutic strategy for overcoming stromal and metabolic barriers in pancreatic cancer and may serve as a foundation for future combination regimens.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • COL1A1 (Collagen Type I Alpha 1 Chain) • ITGA5 (Integrin Subunit Alpha 5)
    6d
    Differential effect of Periodontal pathogen Fusobacterium nucleatum and Porphyromonas gingivalis on modulation of specific partial-EMT genes in colorectal cancer cells. (PubMed, J Oral Biol Craniofac Res)
    Elevated mRNA levels of EMP3, THBS2, and ITGA5 were significantly correlated with poorer overall survival. Fn and Pg can promote invasive phenotypes in CRC through distinct mechanisms, each modulating a unique subset of p-EMT and without instigating a complete, coordinated EMT gene signature.
    Journal
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    SPP1 (Secreted Phosphoprotein 1) • MMP9 (Matrix metallopeptidase 9) • ITK (IL2 Inducible T Cell Kinase) • SNAI1 (Snail Family Transcriptional Repressor 1) • THBS2 (Thrombospondin 2) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • ZEB2 (Zinc Finger E-Box Binding Homeobox 2) • ITGA5 (Integrin Subunit Alpha 5) • MMP3 (Matrix metallopeptidase 3) • P4HA2 (Prolyl 4-Hydroxylase Subunit Alpha 2)
    11d
    Immune and Endothelial-Related Extracellular Vesicles Are Associated with Corticosteroid Response and Mortality in Alcohol-Associated Hepatitis. (PubMed, Int J Mol Sci)
    EVs enriched in platelet (CD49e) and endothelial (CD31) markers were associated with corticosteroid response, whereas EVs enriched with endothelial (CD105 and CD146) and B lymphocyte (CD19) markers were associated with mortality. Overall, EVs enriched in endothelial and monocyte markers may represent a candidate non-invasive tool for predicting corticosteroid response and mortality in AH, aiding risk stratification and early identification of non-responders for timely transplant evaluation.
    Journal • IO biomarker
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    CD20 (Membrane Spanning 4-Domains A1) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL2RA (Interleukin 2 receptor, alpha) • ICAM1 (Intercellular adhesion molecule 1) • CD14 (CD14 Molecule) • MCAM (Melanoma Cell Adhesion Molecule) • CD31 (Platelet and endothelial cell adhesion molecule 1) • CD40 (CD40 Molecule) • ENG (Endoglin) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) • VCAM1 (Vascular Cell Adhesion Molecule 1) • ISG20 (Interferon Stimulated Exonuclease Gene 20) • ITGA5 (Integrin Subunit Alpha 5) • SELP (Selectin P)
    12d
    Mechanism of action of MiR-330-5p targeting ITGA5 in the regulation of proliferation, migration, and invasionof gastric cancer. (PubMed, BMC Cancer)
    miR-330-5p was shown to affect the proliferation, invasion, and migration of gastric cancer cells by mediating ITGA5 through a mechanism possibly associated with the regulation of the FAK/AKT signaling pathway.
    Journal
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    MIR152 (MicroRNA 152) • ITGA5 (Integrin Subunit Alpha 5) • MIR148A (MicroRNA 148a) • MIR148B (MicroRNA 148b) • MIR26A1 (MicroRNA 26a-1) • MIR330 (MicroRNA 330)
    17d
    Multi-omics reveals that CTHRC1 secreted by cancer-associated fibroblasts promotes EMT by ITGA5/PI3K/AKT signaling pathway in HNSCC. (PubMed, Cell Signal)
    This study has confirmed that CTHRC1+ CAFs facilitate HNSCC malignancy via the ITGA5/PI3K/AKT signaling axis. These findings highlight CTHRC1 as a potential prognostic biomarker and therapeutic target in HNSCC.
    Journal • IO biomarker
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    ITGA5 (Integrin Subunit Alpha 5)
    28d
    Engineered cyclic peptide targeting ITGA5 disrupts tumor-stroma interaction to overcome desmoplasia and resistance in pancreatic ductal adenocarcinoma. (PubMed, Acta Pharm Sin B)
    In 3D co-cultured human spheroid models, the peptide decreased markers of resistance (ABCG1, BCL2, CXCR4), stemness (WNT1, CD44) and ECM remodeling (COL1A1, MMP2/9, LOX) and enhanced gemcitabine efficacy...These effects were attributed to reduced desmoplasia, vasculature compression and enhanced infiltration of cytotoxic T cells and apoptosis. This study presents a novel cyclic peptide inhibiting ITGA5-mediated tumor-stroma interaction and thereby reduce desmoplasia and resistance, ultimately enhancing chemotherapy efficacy in PDAC.
    Journal • IO biomarker
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    KRAS (KRAS proto-oncogene GTPase) • TP53 (Tumor protein P53) • BCL2 (B-cell CLL/lymphoma 2) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • MMP2 (Matrix metallopeptidase 2) • COL1A1 (Collagen Type I Alpha 1 Chain) • MMP9 (Matrix metallopeptidase 9) • PDX1 (Pancreatic And Duodenal Homeobox 1) • ABCG1 (ATP Binding Cassette Subfamily G Member 1) • ITGA5 (Integrin Subunit Alpha 5)
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    KRAS G12D • KRAS G12
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    gemcitabine
    1m
    Macrophage-associated immune-stromal crosstalks correlate with the tumor microenvironment in microsatellite-stable mucinous colorectal cancer. (PubMed, Pathol Res Pract)
    Leveraging cell-type-specific genes and key ligand-receptor pairs, we developed a Mucinous Colorectal cancer Immune Module (MCIM) comprising 18 genes, which stratified patient prognosis and was associated with overall survival in colorectal cancer cohorts. Together, these findings provide a detailed map of the immune-stromal architecture in MAC with MSS status, reveal macrophage-associated immunosuppressive features, and propose MCIM as a potential biomarker for prognostication in mucinous colorectal cancer.
    Journal • IO biomarker
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    CXCL8 (Chemokine (C-X-C motif) ligand 8) • SPP1 (Secreted Phosphoprotein 1) • CXCR2 (Chemokine (C-X-C motif) receptor 2) • IL1B (Interleukin 1, beta) • ITGA5 (Integrin Subunit Alpha 5) • ITGB1 (Integrin Subunit Beta 1)
    2ms
    A chemokine-based prognostic model featuring CXCL8, ITGA5, BACE2, CCR7, CERS4, and MEI1 for cervical cancer. (PubMed, Eur J Med Res)
    This study identified a distinct chemokine-driven molecular classification and constructed a chemokine-related prognostic model for cervical cancer. These findings offer novel insights into tumor immunobiology and provide a promising tool for improving individualized risk stratification and therapeutic strategies for cervical cancer.
    Journal • IO biomarker
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    CD8 (cluster of differentiation 8) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • CD4 (CD4 Molecule) • CCR7 (Chemokine (C-C motif) receptor 7) • IL17A (Interleukin 17A) • ITGA5 (Integrin Subunit Alpha 5)
    3ms
    Biomimetic core-shell breast cancer models using alginate, gelatin, and collagen I: simulating the tumor matrix for drug evaluation. (PubMed, Int J Biol Macromol)
    Breast cancer cells proliferated in the core of all prototypes designed, forming spheroids and cell aggregates with a high resistance to doxorubicin. The addition of Collagen I to the developed model enabled the upregulation of malignancy markers (Col1A1, Ki67, FOXC2, SNAI1, NFKB1, WWTR1), invasion markers (WASL, ACTA1, MYO1E, TPM4, PODXL, ITGA2, ITGA5, MENA, EGFR, CDC42), and drug resistance markers (ABCG2, CYP1A1, BAX, HSP90AA1) occurring in vivo. The developed 3D in vitro model can clarify the contribution of the extracellular matrix to the tumor outcome and drug efficacy by replicating some key characteristics of breast tumors, establishing a novel tool for chemotherapeutic agents and drug screening.
    Preclinical • Journal
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    EGFR (Epidermal growth factor receptor) • ABCG2 (ATP Binding Cassette Subfamily G Member 2) • NFKB1 (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) • BAX (BCL2-associated X protein) • COL1A1 (Collagen Type I Alpha 1 Chain) • WWTR1 (WW Domain Containing Transcription Regulator 1) • CDC42 (Cell Division Cycle 42) • PODXL (Podocalyxin) • SNAI1 (Snail Family Transcriptional Repressor 1) • TPM4 (Tropomyosin 4) • ACTA1 (Actin Alpha 1, Skeletal Muscle) • CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1) • ITGA2 (Integrin Subunit Alpha 2) • ITGA5 (Integrin Subunit Alpha 5) • FOXC2 (Forkhead Box C2)
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    doxorubicin hydrochloride
    3ms
    A vascularized 3D bioengineered lung tumor model for anticancer drug screening. (PubMed, Cancer Cell Int)
    Mechanically, hypoxia-activated HIF-1α/LOX signaling promoted ITGA5/FN1-dependent extracellular matrix remodeling and contributed to a chemoprotective niche. This vascularized 3D lung cancer model offers a physiologically relevant and translationally valuable platform for investigating non-small cell lung cancer progression and optimizing patient-specific drug screening.
    Preclinical • Journal
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    HIF1A (Hypoxia inducible factor 1, alpha subunit) • LOX (Lysyl Oxidase) • ITGA5 (Integrin Subunit Alpha 5) • MUC5AC (Mucin 5AC)
    4ms
    Favorable response to daratumumab combination therapy in patients with multiple myeloma with an immature phenotype: a report from the J-CHARGE study group. (PubMed, Int J Hematol)
    Stratifying patients with MM based on myeloma cell maturity provides meaningful information for choosing the best treatment strategy and improving patient outcomes.
    Journal
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    ITGA5 (Integrin Subunit Alpha 5)
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    lenalidomide • bortezomib • Darzalex (daratumumab)
    4ms
    Smoking-Induced STC2+ Tumor Cells Drive Tumor-Vascular Crosstalk in Laryngeal Squamous Cell Carcinoma via Spatial and Single-Cell Transcriptomics. (PubMed, Adv Sci (Weinh))
    This study elucidates the tumor-endothelial interactions mediated by STC2 and ITGA5 in smoking-associated LSCC, emphasizing their roles in tumor progression and vascular permeability. These findings suggest potential prognostic biomarkers and therapeutic targets to improve the clinical management of smoking-associated LSCC.
    Journal
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    STC2 (Stanniocalcin 2) • TGFBI (Transforming Growth Factor Beta Induced) • ITGA5 (Integrin Subunit Alpha 5)