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GENE:

ITGA2 (Integrin Subunit Alpha 2)

News alerts, weekly reports and conference planners

Phenotype of circulating tumor-reactive T cells predicts immune checkpoint inhibitor response in non-small cell lung cancer. (PubMed, Nat Commun)

Additionally, we validate cTR-T's phenotypic changes following PD-1 blockade therapy in mouse tumor models with artificial antigen. These findings suggest that the phenotypic state and transition of cTR-Ts may reflect their functional potential after tumor infiltration and are associated with therapeutic outcomes of ICIs.

6 days ago

Journal • Checkpoint inhibition • PD(L)-1 Biomarker • IO biomarker

CD8 (cluster of differentiation 8) • CD38 (CD38 Molecule) • ITGA1 (Integrin Subunit Alpha 1) • ITGA2 (Integrin Subunit Alpha 2) • TCF7 (Transcription Factor 7)

Equol, a Metabolite of Daidzein, Inhibits IgE-Dependent Basophil Activation by Modulating Intracellular Signaling. (PubMed, J Diet Suppl)

Ionomycin- or thapsigargin-induced CD63 expression was also inhibited by the compound. These results suggest that equol might be a potential candidate as an anti-allergic agent as well as related isoflavones.

9 days ago

Journal

IL4 (Interleukin 4) • ITGA2 (Integrin Subunit Alpha 2)

21d

Proteomic profiling identifies an oncogene ITGA2 and its downstream targets in gastric cancer. (PubMed, Clin Transl Oncol)

Exosomes derived from gastric cancer cells induce ITGA2 overexpression in recipient tumor cells, where ITGA2 functions as an oncogene that promotes proliferation, migration, and invasion. The downstream targets of ITGA2 implicate multiple pro-tumorigenic signaling networks, suggesting that the exosomes-ITGA2 axis may represent a novel therapeutic target in gastric cancer progression and metastasis.

21 days ago

Journal

ITGA2 (Integrin Subunit Alpha 2)

2ms

Decoding anoikis-related genes in lung adenocarcinoma brainmetastasis via single-cell RNA sequencing: CD44-mediated functions. (PubMed, BMC Cancer)

Our findings indicate that epithelial cells undergo profound changes during lung cancer brain metastasis. ARGs, particularly CD44, play a critical role in this process and have prognostic significance for lung cancer brain metastasis.

2 months ago

Journal

BIRC3 (Baculoviral IAP repeat containing 3) • ITGA2 (Integrin Subunit Alpha 2) • ITGA3 (Integrin Subunit Alpha 3)

3ms

Identification of ITGA2 as a methylation-regulated oncogene through a CeRNA network in papillary thyroid carcinoma. (PubMed, Discov Oncol)

This study established a ceRNA regulatory network in PTC and identified ITGA2 as a potential therapeutic target. Its dysregulated expression is closely associated with epigenetic alterations, offering new insights into the molecular mechanisms of PTC progression.

3 months ago

Journal

ITGA2 (Integrin Subunit Alpha 2)

3ms

Biomimetic core-shell breast cancer models using alginate, gelatin, and collagen I: simulating the tumor matrix for drug evaluation. (PubMed, Int J Biol Macromol)

Breast cancer cells proliferated in the core of all prototypes designed, forming spheroids and cell aggregates with a high resistance to doxorubicin. The addition of Collagen I to the developed model enabled the upregulation of malignancy markers (Col1A1, Ki67, FOXC2, SNAI1, NFKB1, WWTR1), invasion markers (WASL, ACTA1, MYO1E, TPM4, PODXL, ITGA2, ITGA5, MENA, EGFR, CDC42), and drug resistance markers (ABCG2, CYP1A1, BAX, HSP90AA1) occurring in vivo. The developed 3D in vitro model can clarify the contribution of the extracellular matrix to the tumor outcome and drug efficacy by replicating some key characteristics of breast tumors, establishing a novel tool for chemotherapeutic agents and drug screening.

3 months ago

Preclinical • Journal

EGFR (Epidermal growth factor receptor) • ABCG2 (ATP Binding Cassette Subfamily G Member 2) • NFKB1 (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) • BAX (BCL2-associated X protein) • COL1A1 (Collagen Type I Alpha 1 Chain) • WWTR1 (WW Domain Containing Transcription Regulator 1) • CDC42 (Cell Division Cycle 42) • PODXL (Podocalyxin) • SNAI1 (Snail Family Transcriptional Repressor 1) • TPM4 (Tropomyosin 4) • ACTA1 (Actin Alpha 1, Skeletal Muscle) • CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1) • ITGA2 (Integrin Subunit Alpha 2) • ITGA5 (Integrin Subunit Alpha 5) • FOXC2 (Forkhead Box C2)

doxorubicin hydrochloride

4ms

The RNA N6-methyladenosine methylome coordinates long non-coding RNAs to mediate cancer drug resistance by activating PI3K signaling. (PubMed, Cell Death Dis)

Treatment with PI3K inhibitor alpelisib eradicates resistant cells in vitro and in vivo, with prolonged survival of leukemic mice through downregulation of F2R, ITGA2, and COL6A1. Thus, the lncRNA-m6A-PI3K cascade represents a new non-genetic predictor for drug resistance and poorer prognosis in cancer, and a pan-cancer mechanism underlying TKI resistance.

4 months ago

Journal

COL6A1 (Collagen Type VI Alpha 1 Chain) • FTO (Alpha-Ketoglutarate-Dependent Dioxygenase FTO) • ITGA2 (Integrin Subunit Alpha 2)

Piqray (alpelisib)

4ms

Development and preclinical evaluation of ovNDV-28: a chimeric Newcastle disease virus expressing human IL-2 for cancer therapy. (PubMed, Cancer Gene Ther)

The virus was detected in tumor tissue, mesenteric lymph nodes, abdominal adipose tissue, brain, and biceps femoris, without evidence of blood circulation or viral shedding. This study systematically demonstrates the efficacy, safety, and pharmacokinetics of ovNDV-28, supporting its potential for clinical translation.

4 months ago

Preclinical • Journal • IO biomarker

CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • CD4 (CD4 Molecule) • IL2 (Interleukin 2) • GZMB (Granzyme B) • ITGA2 (Integrin Subunit Alpha 2)

4ms

The integrin α2-osteoclast axis: a key driver of bone destruction and therapeutic target in osteosarcoma. (PubMed, J Transl Med)

This study uncovered that ITGA2 drives osteosarcoma progression and aggravates osteolysis via the "ITGA2-osteoclast axis", with high expression predicting poor outcomes. Mechanistically, ITGA2 promoted tumor invasion and bone metabolism imbalance by regulating osteoclastogenic signaling, while its targeted inhibition synergistically suppresses tumor growth and restores bone homeostasis, highlighting ITGA2 as a pivotal therapeutic target for osteosarcoma.

4 months ago

Journal

MMP9 (Matrix metallopeptidase 9) • ITGA2 (Integrin Subunit Alpha 2)

E7820

4ms

Bioinformatics analysis to investigate the genetic associations between diabetes and pancreatic cancer. (PubMed, Aging Male)

Six potential therapeutic agents targeting ITGA2, LAMB3, and FN1 were identified. Three genes and associated known drugs identified in this study may serve as potential targets for treating the coexistence of the two diseases.

4 months ago

Journal

LAMC2 (Laminin subunit gamma 2) • ITGA2 (Integrin Subunit Alpha 2) • ITGA3 (Integrin Subunit Alpha 3)

4ms

RNA Signature as Potential Diagnostic Marker for Differentiation of Pancreatic Cysts: A Pilot Study. (PubMed, Int J Mol Sci)

We identified a distinct RNA signature that can distinguish mucinous cystic neoplasms from benign cystic lesions (serous cysts and pseudocysts), which could be useful for guiding patient management and improving clinical outcomes. Validation in broader cohorts is essential for clinical implementation.

4 months ago

Journal

MUC1 (Mucin 1) • MUC4 (Mucin 4, Cell Surface Associated) • ITGA2 (Integrin Subunit Alpha 2) • MUC5AC (Mucin 5AC) • PKM (Pyruvate Kinase M1/2)

4ms

Molecular Adaptations to Repeated Radiation Exposure in Triple-Negative Breast Cancer: Dysregulation of Cell Adhesion, Mitochondrial Function, and Epithelial-Mesenchymal Transition. (PubMed, Int J Mol Sci)

EMT-associated changes included increased mesenchymal markers and loss of epithelial markers (CTNNB1, SNAI2, CK19), consistent with enhanced migratory potential. Taken together, this study delineates key molecular features of radiation adaptation in TNBC, providing a foundation for the development of targeted therapies to overcome treatment resistance.

4 months ago

Journal

CTNNB1 (Catenin (cadherin-associated protein), beta 1) • KRT19 (Keratin 19) • SNAI2 (Snail Family Transcriptional Repressor 2) • ITGA2 (Integrin Subunit Alpha 2) • ITGA6 (Integrin, alpha 6) • ITGB1 (Integrin Subunit Beta 1)