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    GENE:

    ISLR (Immunoglobulin Superfamily Containing Leucine Rich Repeat)

    i
    Other names: ISLR, Immunoglobulin Superfamily Containing Leucine Rich Repeat, HsT17563, Immunoglobulin Superfamily Containing Leucine-Rich Repeat Protein, Mesenchymal Stromal Cell- And Fibroblast-Expressing Linx Paralogue, Meflin
    18d
    Increased Meflin expression in cancer-associated fibroblasts restrains tumor cell proliferation and shapes vessel-rich stroma in triple-negative breast cancer. (PubMed, Am J Pathol)
    Furthermore, Meflin deficiency reduced the area of tumor vessels in a TNBC mouse model, highlighting its role in CAF-mediated inhibition of TNBC progression and improvement of drug delivery. Accordingly, Meflin plays a role as a potential functional marker of rCAFs in TNBC.
    Journal
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    ISLR (Immunoglobulin Superfamily Containing Leucine Rich Repeat) • ACKR3 (Atypical Chemokine Receptor 3) • PTGDS (Prostaglandin D2 Synthase)
    2ms
    Agmatine alleviates sepsis-induced intestinal injury by modulating the nuclear factor-ΚB signaling pathway through immunoglobulin superfamily containing leucine rich repeat to suppress intestinal pyroptosis (PubMed, Zhonghua Wei Zhong Bing Ji Jiu Yi Xue)
    Agmatine may alleviate sepsis-induced intestinal cell injury by inhibiting intestinal cell pyroptosis, potentially through regulating NF-κB signaling via ISLR.
    Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase) • IL1B (Interleukin 1, beta) • ISLR (Immunoglobulin Superfamily Containing Leucine Rich Repeat) • NLRP3 (NLR Family Pyrin Domain Containing 3)
    3ms
    Meflin/ISLR is a meningeal cell-specific marker involved in the development of meninges and meningioma progression. (PubMed, Brain Pathol)
    Furthermore, single-cell RNA sequencing analysis confirmed this finding and revealed elevated WNT6 expression specifically in clusters of Meflin-high tumor cells, highlighting a potential link between Meflin and WNT signaling activation in meningioma progression. Thus, this study provides novel insights into the role of Meflin in meningeal development and meningioma pathophysiology.
    Journal
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    ISLR (Immunoglobulin Superfamily Containing Leucine Rich Repeat)
    8ms
    ISLR knockdown enhances radiotherapy-induced anti-tumor immunity by disrupting the Treg-mregDC-lymphoid niche in triple-negative breast cancer. (PubMed, Int Immunopharmacol)
    ISLR serves as a crucial regulator of immune evasion in TNBC by modulating the MIF/CD74 signaling pathway and promoting an immunosuppressive TME. Targeting ISLR amplifies the immunogenic effects of RT and enhances the response to immunotherapy, offering a promising therapeutic strategy for TNBC management.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    CD8 (cluster of differentiation 8) • CD74 (CD74 Molecule) • IL10 (Interleukin 10) • TGFB1 (Transforming Growth Factor Beta 1) • ISLR (Immunoglobulin Superfamily Containing Leucine Rich Repeat)
    10ms
    Inside a Metastatic Fracture: Molecular Bases and New Potential Therapeutic Targets. (PubMed, Cancer Med)
    This paper underscores the importance of advanced molecular biology and transcriptomics in identifying novel therapeutic targets. The integration of these biomarkers with clinical and radiological assessments using artificial intelligence tools could revolutionize the diagnostics and treatment strategies for patients with bone metastases.
    Review • Journal
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    ISLR (Immunoglobulin Superfamily Containing Leucine Rich Repeat) • TNFRSF11B (Tumor necrosis factor receptor superfamily member 11B)
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    Cilcane (cilengitide) • abituzumab (EMD 525797) • andecaliximab (GS-5745) • volociximab (M200)
    almost2years
    Immunoglobulin Superfamily Containing Leucine-Rich Repeat (ISLR) Serves as a Redox Sensor That Modulates Antioxidant Capacity by Suppressing Pyruvate Kinase Isozyme M2 Activity. (PubMed, Cells)
    In addition, our results demonstrated that, in triple-negative breast cancer, cisplatin treatment reduced the level of ISLR, and PKM2 inhibition sensitizes tumors to cisplatin by enhancing ROS production; and argued that PKM2 inhibition can synergize with cisplatin to limit tumor growth. Our results demonstrate a molecular mechanism by which cells respond to oxidative stress and modulate the redox balance.
    Journal
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    ISLR (Immunoglobulin Superfamily Containing Leucine Rich Repeat)
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    cisplatin
    almost2years
    Progressive changes in the protein expression profile of alveolar septa in early-stage lung adenocarcinoma. (PubMed, Int J Clin Oncol)
    FAP-positive fibroblasts may contribute to tumor stroma formation in early-stage lung adenocarcinoma, and this could influence the development of therapeutic strategies targeting FAP-positive CAFs for disrupting extracellular matrix formation.
    Journal
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    FAP (Fibroblast activation protein, alpha) • ISLR (Immunoglobulin Superfamily Containing Leucine Rich Repeat)
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    FAP expression
    2years
    Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas. (PubMed, J Pathol)
    Together, these data indicate that Meflin may be a marker specific to tissue-resident PSCs and useful for studying their biology in both health and disease.
    Journal
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    GLI1 (GLI Family Zinc Finger 1) • ISLR (Immunoglobulin Superfamily Containing Leucine Rich Repeat) • RSPO3 (R-Spondin 3) • RSPO1 (R-Spondin 1)
    over2years
    Integrated analysis of potential prognosis and differential expression between primary and metastatic foci for COL12A1 in breast cancer (ESMO 2023)
    IHC staining revealed that the expression of COL12A1 was upregulated in primary foci of TNBC. Conclusions In conclusion, COL12A1 may be a poor prognostic predictor and a specific therapeutic target for primary foci in BC, especially in TNBC.
    BRCA Biomarker • Metastases
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    SERPINH1 (Serpin family H member 1) • COL1A1 (Collagen Type I Alpha 1 Chain) • MMP9 (Matrix metallopeptidase 9) • COL3A1 (Collagen Type III Alpha 1 Chain) • COL6A1 (Collagen Type VI Alpha 1 Chain) • ISLR (Immunoglobulin Superfamily Containing Leucine Rich Repeat) • COL11A1 (Collagen Type XI Alpha 1 Chain) • COL12A1 (Collagen Type XII Alpha 1 Chain) • COL5A1 (Collagen Type V Alpha 1 Chain) • COL5A2 (Collagen Type V Alpha 2 Chain) • COL8A1 (Collagen Type VIII Alpha 1 Chain) • MMP8 (Matrix Metallopeptidase 8) • P4HA3 (Prolyl 4-Hydroxylase Subunit Alpha 3)
    over2years
    ISLR interacts with MGAT5 to promote the malignant progression of human gastric cancer AGS cells. (PubMed, Iran J Basic Med Sci)
    MGAT5 overexpression weakened the effects of ISLR knockdown on suppressing the viability, proliferation, migration, invasion, and EMT of gastric cancer cells. ISLR interacted with MGAT5 to promote the malignant progression of gastric cancer.
    Journal
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    ISLR (Immunoglobulin Superfamily Containing Leucine Rich Repeat) • MGAT5 (Alpha-1,6-Mannosylglycoprotein 6-Beta-N-Acetylglucosaminyltransferase)
    almost3years
    Molecular Subtyping and Survival Analysis of Osteosarcoma Reveals Prognostic Biomarkers and Key Canonical Pathways. (PubMed, Cancers (Basel))
    Between the two subtypes, three upregulated genes, POP4, HEY1, CERKL, and seven downregulated genes, CEACAM1, ABLIM1, LTBP2, ISLR, LRRC32, PTPRF, and GPX3, associated with OS metastasis were found to be differentially regulated. Thus, the molecular subtyping results provide a strong basis for classification of OS patients that could be used to develop better prognostic treatment strategies.
    Journal
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    MUC4 (Mucin 4, Cell Surface Associated) • PTPRF (Receptor-type tyrosine-protein phosphatase F) • CEACAM1 (CEA Cell Adhesion Molecule 1) • ISLR (Immunoglobulin Superfamily Containing Leucine Rich Repeat) • MUC2 (Mucin 2) • HEY1 (Hes Related Family BHLH Transcription Factor With YRPW Motif 1) • MUC6 (Mucin 6)