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    BIOMARKER:

    IRS2 mutation

    i
    Other names: IRS2, Insulin Receptor Substrate 2, IRS-2
    Entrez ID:
    8660
    Related biomarkers:
    Mutation
    CNA
    Others
    3years
    The E3 ligase TRAF4 Promotes IGF Signaling by Mediating Atypical Ubiquitination of IRS-1. (PubMed, J Biol Chem)
    Overexpression of TRAF4 enhances IGF1-induced IGFR-IRS-1 interaction, IRS-1 tyrosine phosphorylation, and downstream effector protein activation while mutation of IRS-1 ubiquitination sites completely abolishes these effects. Altogether, our studies demonstrate that non-proteolytic ubiquitination of IRS-1 is a key step in conveying IGF-1 stimulation from IGFR to IRS-1.
    Journal
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    IGF1 (Insulin-like growth factor 1) • IRS1 (Insulin Receptor Substrate 1)
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    IRS2 mutation