IRF4 (Interferon regulatory factor 4)

Our case highlights the potential for diverse morphology in chordomas and emphasizes the utility of an IHC panel, including anti-brachyury antibody, to aid in diagnosis. Our case also demonstrates the importance of evaluating the clivus during postmortem CNS examination.

In CD4+ memory T cells, OCA-B is required to maintain a subset of genes, including Il2, in a transcriptionally poised state, enabling their rapid and robust up-regulation upon repeated stimulation. Moreover, recent studies have indicated an essential role for OCA-B in B-cell malignancy and multiple autoimmune diseases, highlighting OCA-B as a potential therapeutic target for these diseases.

Finally, we showed that gapmer antisense oligonucleotides targeting POU2AF1 inhibit its expression and MM cell growth in the presence of soluble BM stromal cell factors, including IL-6. Our data demonstrate that IL-6-driven B cell-lineage factors are the vulnerability of MM cells and may represent novel therapeutic targets for this incurable tumor.

This study identifies the TET3-IRF4 axis as a central epigenetic driver of immunosuppression in HCC and establishes TET3 siRNA@αmp-Lipo as a potent and translatable nanobiotechnology platform. By integrating targeted siRNA delivery with immune microenvironment remodeling, this strategy provides a promising approach to enhance immunotherapy for HCC and potentially other cancers with immunosuppressive TMEs.

The patient was subsequently recommended for second-line CAR-T therapy in lieu of the planned autologous transplant. This case demonstrates an unusual manifestation of PCL and the importance of maintaining a broad differential diagnosis for hepatic lesions in patients with aggressive plasma cell neoplasms due to its implications for accurate diagnosis and treatment planning.

P2, N=30, Not yet recruiting, Brown University

DLBCL/HGBCL-DH-BCL6 differs from the DLBCL/HGBCL-DH-BCL2, and the DLBCL/HGBCL-TH is associated with the worst survival. Analysis of all three genes of MYC, BCL2 and BCL6 is recommended in the context of DLBCL/HGBCL diagnosis.

Mechanistically, IL-9 promotes intrinsic Arg1 expression through an IRF4-dependent regulatory pathway and modulates arginine and polyamine concentration within IMs and lung tissue, resulting in increased lung tumor growth and altered macrophage phenotypes. Thus, our work defines a protumor function of IL-9-responsive macrophages mediated by altered intrinsic arginine metabolism in lung IMs that enhances lung tumor growth.

The patient was treated with six cycles of Dara-CHOP, followed by autologous stem cell transplantation and maintenance therapy with daratumumab and ibrutinib. This case highlights a rare example of synchronous CLL/SLL-to-PBL transformation in an immunocompetent patient. Integration of detailed molecular diagnostics enabled early recognition and guided a personalized treatment approach incorporating CD38-targeted therapy and BTK inhibition, resulting in an excellent long-term clinical outcome.

P1/2, N=55, Completed, University of Chicago | Active, not recruiting --> Completed