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    BIOMARKER:

    IRF2 overexpression

    i
    Other names: IRF2, Interferon Regulatory Factor 2
    Entrez ID:
    3660
    4years
    IRF2-induced Claudin-7 suppresses cell proliferation, invasion and migration of oral squamous cell carcinoma. (PubMed, Exp Ther Med)
    CLDN7 silencing reversed the inhibitory effects of IRF2 overexpression on the proliferation, invasion and migration of OSCC cells. Taken together, these findings demonstrated that IRF2-induced CLDN7 upregulation suppressed the proliferation, invasion and migration of OSCC cells, suggesting the possibility of CLDN7 and IRF2 as novel targets for the treatment of OSCC.
    Journal
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    IRF2 (Interferon Regulatory Factor 2)
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    IRF2 overexpression