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GENE:

IRF1 (Interferon Regulatory Factor 1)

News alerts, weekly reports and conference planners

Integration of multi-omics and machine learning to identify core genes in PANoptosisof lung adenocarcinoma and their mechanisms in the tumor microenvironment and therapeutic potential. (PubMed, Naunyn Schmiedebergs Arch Pharmacol)

This study systematically revealed a PANoptosis core gene network centered on M2 macrophages in LUAD, elucidating a new mechanism by which ginsenosides induce integrated cell death by regulating this network. This provides new potential targets and theoretical basis for the immunotherapy of LUAD and the development of traditional Chinese medicine monomers.

6 days ago

Journal • IO biomarker

S100A8 (S100 Calcium Binding Protein A8) • TIMP1 (Tissue inhibitor of metalloproteinases 1) • IRF1 (Interferon Regulatory Factor 1) • TLR4 (Toll Like Receptor 4) • IGF2BP1 (Insulin Like Growth Factor 2 MRNA Binding Protein 1) • NLRP3 (NLR Family Pyrin Domain Containing 3)

14d

Causal Effects of a Hepatic Senescence Gene Set on MASLD Fibrosis: A Mendelian Randomization Study and Quercetin Molecular Docking Analysis. (PubMed, Biomedicines)

GBP2 might modulate hepatic fibrosis and cholangiocarcinoma. Quercetin may exert antifibrotic effects by indirectly modulating GBP2.

14 days ago

Journal

IRF1 (Interferon Regulatory Factor 1)

17d

APOBEC3B regulates HPV replication by inducing R-loop formation and DNA damage. (PubMed, PLoS Pathog)

Furthermore, A3B depletion resulted in over a 50% reduction of DNA breaks along with altered expression of DNA damage repair proteins. This study demonstrates that A3B is an inducer of R-loop formation and DNA damage in HPV positive cells, thereby regulating cellular and viral gene expression along with HPV replication.

17 days ago

Journal

IL6 (Interleukin 6) • IRF1 (Interferon Regulatory Factor 1) • APOBEC3B (Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3B) • OASL (2'-5'-Oligoadenylate Synthetase Like)

17d

Inhibition of RAB7 promotes CD8+ T cell activation via the STING/IRF1/CCL5/CXCL10 signaling axis to promote PD-1-mediated anti-lung cancer efficacy. (PubMed, Am J Cancer Res)

STING knockdown reversed all anti-tumor and immune activation effects mediated by RAB7 knockdown. In summary, knockdown of RAB7 activated the STING/IRF1/CCL5/CXCL10 signaling pathway by blocking autophagy flux, enhanced the activation and infiltration of CD8+ T cells, and significantly enhanced PD-1 antibody efficacy against lung cancer.

17 days ago

Journal • PD(L)-1 Biomarker • IO biomarker

CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • STING (stimulator of interferon response cGAMP interactor 1) • IRF1 (Interferon Regulatory Factor 1) • ENTPD1 (Ectonucleoside Triphosphate Diphosphohydrolase 1) • PRF1 (Perforin 1)

25d

Targeting MUC16 Suppresses Malignant Progression and Chemoresistance in Large-duct Type Intrahepatic Cholangiocarcinoma. (PubMed, Cancer Lett)

Employing a genetically engineered L-iCCA mouse model, we further validated the crucial role of MUC16 in tumor progression and neutrophil infiltration, demonstrated that OSMI-1 synergized with gemcitabine, effectively inhibiting L-iCCA growth. This study presents a pathological subtype-based precision therapeutic strategy for L-iCCA, thereby providing a foundation for novel translational approaches to the personalized management of this disease.

25 days ago

Journal

MUC16 (Mucin 16, Cell Surface Associated) • IRF1 (Interferon Regulatory Factor 1)

gemcitabine

25d

Inhibition of CDK1 Promotes Immunogenic Cell Death in Neuroblastoma. (PubMed, Cancer Manag Res)

CDK1 inhibition not only slows neuroblastoma progression but also triggers DAMP release consistent with ICD and immune activation. CDK1 may be a potential prognostic marker and effective treatment target for improving immunotherapy efficacy in neuroblastoma patients.

25 days ago

Journal • IO biomarker

IFNG (Interferon, gamma) • HMGB1 (High Mobility Group Box 1) • IRF1 (Interferon Regulatory Factor 1) • CDK1 (Cyclin-dependent kinase 1)

AGPAT3 reshapes tumor cell vulnerability to IFNγ-mediated ferroptosis and enhances immunotherapy efficacy through lipid remodeling. (PubMed, J Immunother Cancer)

The IFN-γ-IRF1-AGPAT3 axis represents an important antitumor mechanism that promotes ferroptosis. Targeting this pathway in combination with our ferroptosis-driver model prediction may improve ICI efficacy and patient outcomes.

1 month ago

Journal • IO biomarker

IFNG (Interferon, gamma) • IRF1 (Interferon Regulatory Factor 1)

ScRNA-seq reveals dynamic macrophage heterogeneity in chronic liver disease progression and prognostic biomarkers KLF2/SPP1 in HCC. (PubMed, Front Immunol)

FISH confirmed stage-specific shifts in macrophage abundances and close spatial interactions between SPP1+ macrophages and Tc in HCC specimens. We provided a stage-resolved framework to delineated macrophage heterogeneity during CLDs progression and identified SPP1 and KLF2 as candidate prognostic biomarkers and potential therapeutic targets in HCC.

1 month ago

Journal

CXCL10 (Chemokine (C-X-C motif) ligand 10) • SPP1 (Secreted Phosphoprotein 1) • IRF1 (Interferon Regulatory Factor 1) • CXCL3 (C-X-C Motif Chemokine Ligand 3)

Neutrophil extracellular trap-related genes in PTCL: identification, prognosis and drug interaction prediction via bioinformatics-machine learning. (PubMed, Hematology)

Potential therapeutic agents (e.g. capivasertib, lenalidomide) were predicted, and lenalidomide may represent a feasible initial treatment option for PTCL, with an objective response rate (ORR) of 40.0% and a maximum survival duration exceeding 50 months. NET-RGs play crucial roles in diagnosis, prognosis, and TME regulation, and lenalidomide, a putative TNF-targeting agent, may represent a feasible initial treatment option in PTCL.

1 month ago

Journal

AKT2 (V-akt murine thymoma viral oncogene homolog 2) • IRF1 (Interferon Regulatory Factor 1) • MAPK14 (Mitogen-Activated Protein Kinase 14)

lenalidomide • Truqap (capivasertib)

Integrated transcriptomics and molecular docking identify hub genes and statin regulators in Helicobacter pylori-associated gastric mucosal pathogenesis. (PubMed, Front Cell Infect Microbiol)

To explore potential therapeutic interventions, we performed small-molecule drug prediction and molecular docking for hub genes revealed: Simvastatin: Linked to CCL20, NFKBIA, and ICAM1. Atorvastatin: Associated with CDKN1A, ICAM1, and TNF. TPCA-1: Targeting JAK1. These findings provide a theoretical foundation for further investigation into the molecular mechanisms underlying H. pylori-related diseases.

1 month ago

Journal

BRCA1 (Breast cancer 1, early onset) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • BIRC3 (Baculoviral IAP repeat containing 3) • JAK1 (Janus Kinase 1) • TNFAIP3 (TNF Alpha Induced Protein 3) • CCL20 (C-C Motif Chemokine Ligand 20) • ICAM1 (Intercellular adhesion molecule 1) • IRF1 (Interferon Regulatory Factor 1) • ITGAM (Integrin, alpha M) • SPI1 (Spi-1 Proto-Oncogene) • ETS1 (ETS Proto-Oncogene 1) • IL17A (Interleukin 17A) • STAT1 (Signal Transducer And Activator Of Transcription 1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • NFKB2 (Nuclear Factor Kappa B Subunit 2) • NFKBIA (NFKB Inhibitor Alpha 2) • NFKBIE (NFKB Inhibitor Epsilon) • TRAF1 (TNF Receptor Associated Factor 1) • CXCL1 (Chemokine (C-X-C motif) ligand 1) • E2F1 (E2F transcription factor 1) • EGR1 (Early Growth Response 1) • HSF1 (Heat Shock Transcription Factor 1) • JUNB (JunB Proto-Oncogene AP-1 Transcription Factor Subunit)

simvastatin • atorvastatin

MVP Inhibits Influenza A Virus-Induced Ferroptosis by Targeting IRF1 and Increasing FSP1 Activity. (PubMed, Adv Sci (Weinh))

In the presence of the MVP, transcriptionally induced FSP1 is released from IRF1, leading to its ubiquitination and myristoylation, which enable its recruitment to the plasma membrane, where it functions as an oxidoreductase. These findings define a ferroptosis suppression pathway during IAV infection.

1 month ago

Journal

TNFA (Tumor Necrosis Factor-Alpha) • GPX4 (Glutathione Peroxidase 4) • IRF1 (Interferon Regulatory Factor 1) • MVP (Major Vault Protein) • AIFM2 (Apoptosis Inducing Factor Mitochondria Associated 2) • TRAF6 (TNF Receptor Associated Factor 6)