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BIOMARKER:

IRF1 expression

i
Other names: Interferon Regulatory Factor 1, IRF 1, Interferon Regulatory Factor 1 Isoform D9 10, Interferon Regulatory Factor 1 Isoform Delta4, Interferon Regulatory Factor 1 Isoform Delta7, Interferon Regulatory Factor 1 Isoform +I9, Interferon Regulatory Factor 1 Isoform D78
Entrez ID:
2ms
NAT10-mediated upregulation of GAS5 facilitates immune cell infiltration in non-small cell lung cancer via the MYBBP1A-p53/IRF1/type I interferon signaling axis. (PubMed, Cell Death Discov)
A schematic diagram demonstrating the regulatory effect of GAS5 on immune cell infiltration by activating type I interferon signaling via MYBBP1A-p53/IRF1 axis in non-small cell lung cancer. IFN, interferon.
Journal • IO biomarker • Immune cell
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CXCL10 (Chemokine (C-X-C motif) ligand 10) • IRF1 (Interferon Regulatory Factor 1) • GAS5 (Growth Arrest Specific 5)
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IRF1 expression
2ms
Combination of percutaneous thermal ablation and adoptive Th9 cell transfer therapy against non-small cell lung cancer. (PubMed, Exp Hematol Oncol)
Collectively, this study demonstrates that combinatorial therapy displays robust and durable anti-tumor efficacy and excellent translational potential, offering excellent prospects for translation and emerging as a promising approach for NSCLC treatment.
Journal
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CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • IRF1 (Interferon Regulatory Factor 1) • IL1B (Interleukin 1, beta)
|
IRF1 expression
3ms
The role of PANoptosis in renal vascular endothelial cells: Implications for trichloroethylene-induced kidney injury. (PubMed, Ecotoxicol Environ Saf)
These results suggest that the efficacy of rh TNFR:Fc may be influenced by TNFα and IFNγ-mediated PANoptosis in kidney vascular endothelial cells. The joint application of TNFα and IFNγ neutralizing antibody represented a solid alternative to existing therapeutics.
Journal
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IFNG (Interferon, gamma) • IRF1 (Interferon Regulatory Factor 1)
|
IRF1 expression
3ms
Development of Aptamer-DNAzyme based metal-nucleic acid frameworks for gastric cancer therapy. (PubMed, Nat Commun)
This MNF nanodevice disrupts GSH/ROS homeostasis, suppresses DNA repair, and augments ROS-mediated DNA damage therapy, with tumor inhibition rate up to 90%. Our work signifies a significant advancement towards an era of universal MNF application.
Journal
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HER-2 (Human epidermal growth factor receptor 2) • IRF1 (Interferon Regulatory Factor 1) • SLC2A1 (Solute Carrier Family 2 Member 1)
|
HER-2 expression • EGFR positive • IRF1 expression
3ms
Grainyhead-like-2, an epithelial master programmer, promotes interferon induction and suppresses breast cancer recurrence. (PubMed, Mol Immunol)
Moreover, time to recurrence in breast cancer correlated positively with GRHL2 protein expression, indicating that GRHL2 is a tumor recurrence suppressor, consistent with its enhancement of interferon responses. These observations demonstrate that epithelial cell identity supports interferon responses in the context of cancer.
Journal
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IRF1 (Interferon Regulatory Factor 1) • IFNL1 (Interferon Lambda 1)
|
IRF1 expression
3ms
Nucleic acid-sensing-related gene signature in predicting prognosis and treatment efficiency of small cell lung cancer patients. (PubMed, Front Oncol)
Additionally, Patients in the low-risk group might have superior responses to chemotherapy and immunotherapy. Conclusively, this study created a new risk model based on genes associated with NAS pathways which could predict the prognosis and response of treatment in patients with SCLC.
Journal • Gene Signature • IO biomarker
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CD8 (cluster of differentiation 8) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • CD68 (CD68 Molecule) • IRF1 (Interferon Regulatory Factor 1)
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IRF1 expression
3ms
Bioinformatics and system biology approach to identify the influences among COVID-19, influenza, and HIV on the regulation of gene expression. (PubMed, Front Immunol)
Additionally, five crucial miRNAs (hsa-miR-8060, hsa-miR-6890-5p, hsa-miR-5003-3p, hsa-miR-6893-3p, and hsa-miR-6069), five essential transcription factors (CREB1, CEBPB, EGR1, EP300, and IRF1), and the top ten significant drug chemicals (estradiol, progesterone, tretinoin, calcitriol, fluorouracil, methotrexate, lipopolysaccharide, valproic acid, silicon dioxide, cyclosporine) were identified. This research provides valuable insights into shared molecular targets, signaling pathways, drug chemicals, and potential biomarkers for individuals facing the complex intersection of COVID-19, influenza, and HIV. These findings hold promise for enhancing the precision of diagnosis and treatment for individuals with HIV co-infected with COVID-19 and influenza.
Journal
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EP300 (E1A binding protein p300) • IRF1 (Interferon Regulatory Factor 1) • CREB1 (CAMP Responsive Element Binding Protein 1) • IFI27 (Interferon Alpha Inducible Protein 27) • OASL (2'-5'-Oligoadenylate Synthetase Like) • EGR1 (Early Growth Response 1) • EPSTI1 (Epithelial Stromal Interaction 1)
|
IRF1 expression
|
5-fluorouracil • methotrexate • cyclosporine
4ms
Formononetin attenuates psoriasiform inflammation by regulating interferon signaling pathway. (PubMed, Phytomedicine)
In summary, these results suggested that FMN played an anti-inflammatory and anti-proliferative role in alleviating psoriasis by inhibiting IFN signaling pathway, and FMN could be used as a potential therapeutic agent.
Journal
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IFNG (Interferon, gamma) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • STAT3 (Signal Transducer And Activator Of Transcription 3) • CXCL9 (Chemokine (C-X-C motif) ligand 9) • CXCL11 (C-X-C Motif Chemokine Ligand 11) • IRF1 (Interferon Regulatory Factor 1) • IL17A (Interleukin 17A) • CXCR3 (C-X-C Motif Chemokine Receptor 3) • IFNA1 (Interferon Alpha 1) • IFNB1 (Interferon Beta 1)
|
IRF1 expression
|
Zyclara (imiquimod)
4ms
Mismatch repair protein deficiency and its implications on distant metastasis in colorectal cancer: A comprehensive analysis. (PubMed, Cancer Med)
Geographical and ethnic factors might influence peculiarities in MMR protein loss. Our findings also highlight new gene expression networks and crucial regulatory molecules in CRC metastasis, enhancing our comprehension of the mechanisms driving distant metastasis.
Journal • Mismatch repair
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MLH1 (MutL homolog 1) • MSH6 (MutS homolog 6) • MSH2 (MutS Homolog 2) • PMS2 (PMS1 protein homolog 2) • IRF1 (Interferon Regulatory Factor 1)
|
MSI-H/dMMR • IRF1 expression • MSH6 expression
4ms
Activation of endogenous retroviruses and induction of viral mimicry by MEK1/2 inhibition in pancreatic cancer. (PubMed, Sci Adv)
We tracked ERV activation to the early induction of the transcription factor ELF3, which extensively bound and activated nonsilenced retroelements and synergized with IRF1 (interferon regulatory factor 1) in the activation of IFNs and IFN-stimulated genes. Trametinib-induced viral mimicry in PDAC may be exploited in the rational design of combination therapies in immuno-oncology.
Journal • IO biomarker
|
KRAS (KRAS proto-oncogene GTPase) • IRF1 (Interferon Regulatory Factor 1) • ELF3 (E74 Like ETS Transcription Factor 3)
|
KRAS mutation • MAP2K1 mutation • IRF1 expression
|
Mekinist (trametinib)
4ms
Transforming Growth Factor Beta 2 (TGFB2) mRNA Levels, in Conjunction with Interferon-Gamma Receptor Activation of Interferon Regulatory Factor 5 (IRF5) and Expression of CD276/B7-H3, Are Therapeutically Targetable Negative Prognostic Markers in Low-Grade Gliomas. (PubMed, Cancers (Basel))
In support of these findings, we demonstrated that low levels of gene methylation in TGFB2, IFNGR2, IRF1, IRF5, STAT1, and CD276 were associated with significantly worse overall survival (OS) outcomes. This suggests that potential mechanisms to increase the expression of these prognostic markers occur via the action of demethylation enzymes.
Journal
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IFNG (Interferon, gamma) • CD276 (CD276 Molecule) • CD68 (CD68 Molecule) • IRF1 (Interferon Regulatory Factor 1) • TGFB1 (Transforming Growth Factor Beta 1) • STAT1 (Signal Transducer And Activator Of Transcription 1) • IFNAR2 (Interferon Alpha And Beta Receptor Subunit 2) • CD86 (CD86 Molecule) • IFNGR1 (Interferon Gamma Receptor 1) • IRF5 (Interferon Regulatory Factor 5) • MSR1 (Macrophage Scavenger Receptor 1) • TGFB2 (Transforming Growth Factor Beta 2)
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IDH wild-type • IRF1 expression
4ms
An international phase II trial and immune profiling of SBRT and atezolizumab in advanced pretreated colorectal cancer. (PubMed, Mol Cancer)
This study provides new data on the feasibility, efficacy, and immune context of tumors that may help identifying advanced CRC patients most likely to respond to immuno-radiotherapy.
P2 data • Journal • PD(L)-1 Biomarker • IO biomarker • Metastases
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CXCL9 (Chemokine (C-X-C motif) ligand 9) • CCL19 (C-C Motif Chemokine Ligand 19) • CD68 (CD68 Molecule) • GZMB (Granzyme B) • IRF1 (Interferon Regulatory Factor 1)
|
PD-L1 expression • IRF1 expression
|
Tecentriq (atezolizumab)
4ms
An IRF2-Expressing Oncolytic Virus Changes the Susceptibility of Tumor Cells to Antitumor T cells and Promotes Tumor Clearance. (PubMed, Cancer Immunol Res)
Finally, using an oncolytic vaccinia virus as a delivery platform, we showed that IRF2-expressing vaccinia virus suppressed tumor progression and prolonged survival in multiple tumor models. These results suggest the potency of targeting IRF1 and using IRF2 to modulate immunotherapy.
Journal • Oncolytic virus • IO biomarker • Tumor cell
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IRF1 (Interferon Regulatory Factor 1) • IRF2 (Interferon Regulatory Factor 2)
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IRF1 expression
4ms
Identification of estrogen response-associated STRA6+ granulosa cells within high-grade serous ovarian carcinoma by single-cell sequencing. (PubMed, Heliyon)
There is extreme heterogeneity of epithelial cells in HGSOC, and STRA6+ granulosa cells may be able to promote cancer progression. Our findings are benefit to the heterogeneity identification of HGSOC and develop targeted therapy strategy for HGSOC patients.
Journal
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AURKA (Aurora kinase A) • IRF1 (Interferon Regulatory Factor 1) • STRA6 (Signaling Receptor And Transporter Of Retinol STRA6)
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IRF1 expression • STRA6 expression
4ms
Interferon-γ in the tumor microenvironment promotes the expression of B7H4 in colorectal cancer cells, thereby inhibiting cytotoxic T cells. (PubMed, Sci Rep)
The clinical outcome of patients with CRC was negatively related to the high expression of B7H4 in cancer cells or low expression of CD8 in the microenvironment. Therefore, B7H4 is a biomarker of poor prognosis in CRC patients, and interference with the IFN-γ/IRF1/B7H4 axis might be a novel immunotherapeutic method to restore the cytotoxic killing of CRC cells.
Journal • IO biomarker
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CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1) • GZMB (Granzyme B) • IRF1 (Interferon Regulatory Factor 1)
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CD8 expression • VTCN1 underexpression • IFNG expression • IRF1 expression
4ms
Mefloquine enhances the efficacy of anti-PD-1 immunotherapy via IFN-γ-STAT1-IRF1-LPCAT3-induced ferroptosis in tumors. (PubMed, J Immunother Cancer)
In conclusion, our study demonstrated a novel mechanism by which LPCAT3 is regulated, and demonstrated that Mef is a highly promising new target that can be utilized to enhance the efficacy of anti-PD-1 immunotherapy.
Journal • PD(L)-1 Biomarker • IO biomarker
|
IFNG (Interferon, gamma) • IRF1 (Interferon Regulatory Factor 1) • STAT1 (Signal Transducer And Activator Of Transcription 1) • LPCAT3 (Lysophosphatidylcholine Acyltransferase 3)
|
IRF1 expression
4ms
Cytochrome P450 genes expression in human prostate cancer. (PubMed, Mol Genet Metab Rep)
Therefore, the expression of CYPs is not directly associated with prostate cancer but is largely determined by genetic, epigenetic factors, as well as endogenous substrates and xenobiotics. The significant correlative relationship between CYPs and genes associated with cancer may indicate common regulatory pathways that may have a synergistic effect on the tumor, ensuring the survival of cancer cells.
Journal
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ACTA2 (Actin Alpha 2 Smooth Muscle) • CYP17A1 (Cytochrome P450 Family 17 Subfamily A Member 1) • IRF1 (Interferon Regulatory Factor 1) • CDH2 (Cadherin 2) • MMP9 (Matrix metallopeptidase 9) • CYP3A5 (Cytochrome P450 Family 3 Subfamily A Member 5) • CXCL14 (C-X-C Motif Chemokine Ligand 14) • CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1) • CYP27A1 (Cytochrome P450 Family 27 Subfamily A Member 1) • CYP2R1 (Cytochrome P450 Family 2 Subfamily R Member 1) • VDR (Vitamin D Receptor)
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IRF1 expression • CYP17A1 expression • CYP4B1 expression
4ms
The RNA m6A reader IGF2BP3 regulates NFAT1/IRF1 axis-mediated anti-tumor activity in gastric cancer. (PubMed, Cell Death Dis)
Elevated IGF2BP3 promotes in vivo and in vitro GC progression via regulation of NFAT1/IRF1 pathways. Targeted inhibition of IGF2BP3 might be a potential therapeutic approach for GC treatment.
Journal
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IRF1 (Interferon Regulatory Factor 1) • NFATC1 (Nuclear Factor Of Activated T Cells 1) • IGF2BP3 (Insulin Like Growth Factor 2 MRNA Binding Protein 3)
|
IRF1 expression • IGF2 elevation • IGFBP3 elevation
5ms
IFNT-induced IRF1 enhances bovine endometrial receptivity by transactivating LIFR. (PubMed, J Reprod Immunol)
Dual luciferase reporter assay verified that IRF1 could transactivate LIFR transcription by binding to its promoter. In conclusion, IFN-τ can induce IRF1 expression in bovine endometrial epithelial cells, and IRF1 upregulates LIFR expression by binding to LIFR promoter, contributing to the enhancement of bovine endometrial receptivity.
Journal
|
CDH1 (Cadherin 1) • IRF1 (Interferon Regulatory Factor 1) • LIFR (LIF Receptor Subunit Alpha) • ITGAV (Integrin Subunit Alpha V) • HOXA10 (Homeobox A10) • ITGB3 (Integrin Subunit Beta 3) • LIF (LIF Interleukin 6 Family Cytokine)
|
CDH1 expression • IRF1 expression • LIFR expression
5ms
Atherosclerosis Deteriorates Liver Ischemia/Reperfusion Injury Via Interferon Regulatory Factor-1 Overexpression in a Murine Model. (PubMed, Transplant Proc)
These findings suggest that in an atherosclerotic mouse model, atherosclerosis can mirror intrahepatic immunity, particularly activating liver NK and T cells through IL-15 production, thereby exacerbating hepatic damage. The upregulation of IL-15 expression is associated with IRF-1 overexpression.
Preclinical • Journal
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IRF1 (Interferon Regulatory Factor 1) • APOE (Apolipoprotein E) • IL15 (Interleukin 15)
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IRF1 expression
5ms
Glutamine inhibition combined with CD47 blockade enhances radiotherapy-induced ferroptosis in head and neck squamous cell carcinoma. (PubMed, Cancer Lett)
Dual-blocking glutamine and CD47 promote tumor remission and enhance RT-induced ferroptosis, thereby ameliorating the tumor microenvironment. Our work provides valuable insights into the metabolic and immunological mechanisms underlying RT-induced ferroptosis, highlighting a promising strategy to augment RT efficacy in HNSCC.
Journal
|
CD47 (CD47 Molecule) • SLC1A5 (Solute Carrier Family 1 Member 5) • IRF1 (Interferon Regulatory Factor 1)
|
IRF1 expression • CD47 expression
5ms
Defining Melanoma Immune Biomarkers-Desert, Excluded, and Inflamed Subtypes-Using a Gene Expression Classifier Reflecting Intratumoral Immune Response and Stromal Patterns. (PubMed, Biomolecules)
Our findings suggest that melanoma tumors can be classified into transcriptionally and histologically distinct desert, excluded, and inflamed subtypes. Gene expression-based algorithms can assist physicians and pathologists as biomarkers in the rapid assessment of a tumor immune microenvironment while serving as a tool for clinical decision making.
Journal • Stroma
|
IRF1 (Interferon Regulatory Factor 1) • CD2 (CD2 Molecule) • CD53 (CD53 Molecule) • COL5A2 (Collagen Type V Alpha 2 Chain)
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IRF1 expression
5ms
Roles of Interferon Regulatory Factor 1 in Tumor Progression and Regression: Two Sides of a Coin. (PubMed, Int J Mol Sci)
Numerous mechanisms of IRF1 regulation in cancer have been identified, including genetic, epigenetic, transcriptional, post-transcriptional, and post-translational mechanisms, although their significance for tumor progression remains to be explored. This review will focus on the established tumor-suppressive and tumor-promoting functions of IRF1, as well as the molecular mechanisms of IRF1 regulation identified in various cancers.
Review • Journal
|
PD-L1 (Programmed death ligand 1) • IRF1 (Interferon Regulatory Factor 1)
|
IRF1 expression
5ms
Targeting autophagy overcomes cancer-intrinsic resistance to CAR-T immunotherapy in B-cell malignancies. (PubMed, Cancer Commun (Lond))
These findings confirm that autophagy signaling in B-cell malignancies is essential for the effective cytotoxic function of CAR-T cells and thereby pave the way for the development of autophagy-targeting strategies to improve the clinical efficacy of CAR-T cell immunotherapy.
Journal • IO biomarker
|
TNFA (Tumor Necrosis Factor-Alpha) • TNFRSF1A (TNF Receptor Superfamily Member 1A) • IRF1 (Interferon Regulatory Factor 1) • STAT1 (Signal Transducer And Activator Of Transcription 1) • ATG3 (Autophagy Related 3) • BECN1 (Beclin 1) • RB1CC1 (RB1 Inducible Coiled-Coil 1)
|
IRF1 expression
5ms
LATS1/2 loss promote tumor immune evasion in endometrial cancer through downregulating MHC-I expression. (PubMed, J Exp Clin Cancer Res)
Our findings indicate that dysregulation of LATS1/2 in EC leads to immune evasion through the down-regulation of MHC-I, leading to the suppression of infiltrating activated CD8 + T cells and highlight the importance of LATS1/2 in IFN-γ signaling-mediated tumor immune response, suggesting that LATS1/2 is a promising target for immune checkpoint blockade therapy in EC.
Journal
|
CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • IRF1 (Interferon Regulatory Factor 1) • NLRC5 (NLR Family CARD Domain Containing 5) • STAT1 (Signal Transducer And Activator Of Transcription 1) • LATS1 (Large Tumor Suppressor Kinase 1)
|
IRF1 expression
5ms
CD38-directed, single-chain T cell-engager targets leukemia stem cells through IFNγ-induced CD38 expression. (PubMed, Blood)
Critically, while BN-CD38 showed significant in vivo efficacy across multiple disseminated AML cell lines and patient derived xenograft models, it did not affect normal hematopoietic stem cell clonogenicity and the development of multi-lineage human immune cells in CD34pos humanized mice. Taken together, this study provides important insights to target and eliminate AML LSCs.
Journal • IO biomarker
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CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • CD38 (CD38 Molecule) • IRF1 (Interferon Regulatory Factor 1)
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CD38 expression • IFNG expression • IRF1 expression
5ms
Epstein-Barr Virus Promotes Tumorigenicity and Worsens Hodgkin Lymphoma Prognosis by Activating JAK/STAT and NF-κB Signaling Pathways. (PubMed, Iran J Med Sci)
Through the activation of JAK/STAT and NF-κB signaling pathways, EBV-positive CHL is associated with poor clinicopathological parameters, higher incidence of disease progression, relapse, and poor overall survival. A preprint of this manuscript is available on research square (doi: 10.21203/rs.3.rs-1857436/v1).
Journal • PD(L)-1 Biomarker • IO biomarker
|
PD-L1 (Programmed death ligand 1) • JAK2 (Janus kinase 2) • IFNG (Interferon, gamma) • BCL2L1 (BCL2-like 1) • IRF1 (Interferon Regulatory Factor 1) • STAT1 (Signal Transducer And Activator Of Transcription 1)
|
IRF1 expression
5ms
Molecular Atlas of HER2+ Breast Cancer Cells Treated with Endogenous Ligands: Temporal Insights into Mechanisms of Trastuzumab Resistance. (PubMed, Cancers (Basel))
Our results provide novel insights into mechanistic changes underlying ligand treatment in BT474 and BT474R and emphasize the pivotal role of endogenous ligands. These results can serve as a framework for furthering the understanding of trastuzumab resistance, with therapeutic implications for women with acquired resistance.
Journal
|
HER-2 (Human epidermal growth factor receptor 2) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • IRF1 (Interferon Regulatory Factor 1) • STAT1 (Signal Transducer And Activator Of Transcription 1)
|
AR expression • IRF1 expression
|
Herceptin (trastuzumab)
6ms
TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression. (PubMed, J Cell Biol)
Consequently, ELAVL1 determines death receptors-initiated caspase-8-dependent cell death triggered from stimuli including TNF and TRAIL by regulating basal/stimulated caspase-8 levels. As caspase-8 is a master regulator in cell death and inflammation, these results provide valuable clues for tumor immunotherapy and inflammatory diseases.
Journal • PD(L)-1 Biomarker • IO biomarker
|
IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • CASP8 (Caspase 8) • IRF1 (Interferon Regulatory Factor 1) • ELAVL1 (ELAV Like RNA Binding Protein 1)
|
IFNG expression • IRF1 expression
6ms
The crosstalk of CD8+ T cells and ferroptosis in cancer. (PubMed, Front Immunol)
Together, these factors build a complex network of CD8+ T cells and ferroptosis in cancer. Therefore, we aim to integrate relevant studies to reveal the potential mechanisms of crosstalk between CD8+ T cells and ferroptosis, and to summarize preclinical models in cancer therapy to find new therapeutic strategies in this review.
Review • Journal
|
CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • IRF8 (Interferon Regulatory Factor 8) • IRF1 (Interferon Regulatory Factor 1)
|
IRF1 expression • FASN-L
6ms
Cediranib enhances the transcription of MHC-I by upregulating IRF-1. (PubMed, Biochem Pharmacol)
In vivo study, we further confirmed that cediranib increased MHC-I expression, enhanced CD8 T cell infiltration, and improved the efficacy of anti-PD-L1 therapy. Collectively, our study demonstrated that cediranib could elevate MHC-I expression and enhance responsiveness to immune therapy, thereby providing a theoretical foundation for its potential clinical trials in combination with immunotherapy.
Journal • PD(L)-1 Biomarker • IO biomarker
|
CD8 (cluster of differentiation 8) • IRF1 (Interferon Regulatory Factor 1)
|
CD8 expression • IRF1 expression
|
Recentin (cediranib)
6ms
Exploration of the shared gene signatures and biological mechanisms between ischemia-reperfusion injury and antibody-mediated rejection in renal transplantation. (PubMed, Transpl Immunol)
Inflammation is a key mechanism that links IRI and ABMR, with a potential role played by CD4 memory T cells. Furthermore, TNFAIP3, IRF1, and EGR2 are implicated in the underlying mechanism between IRI and ABMR.
Journal • Gene Signature
|
CD4 (CD4 Molecule) • TNFAIP3 (TNF Alpha Induced Protein 3) • IRF1 (Interferon Regulatory Factor 1)
|
IRF1 expression
6ms
MICA+ Tumor Cell Upregulated Macrophage-Secreted MMP9 via PROS1-AXL Axis to Induce Tumor Immune Escape in Advanced Hepatocellular Carcinoma (HCC). (PubMed, Cancers (Basel))
MICA+ HCC cells secreted PROS1, which upregulated MMP9 expression in macrophages through AXL receptors. The increased MMP9 activity resulted in the proteolytic shedding of MICA, leading to the release of soluble MICA (sMICA) and the subsequent facilitation of tumor immune escape.
Journal • Tumor cell • Metastases
|
AXL (AXL Receptor Tyrosine Kinase) • IFNG (Interferon, gamma) • IRF1 (Interferon Regulatory Factor 1) • MMP9 (Matrix metallopeptidase 9) • MICA (MHC Class I Polypeptide-Related Sequence A)
|
IRF1 expression
6ms
The molecular mechanism of sepsis-induced diaphragm dysfunction. (PubMed, J Thorac Dis)
Sepsis-induced diaphragm dysfunction in mice is closely correlated with the activation of TLR signaling pathway, NF-κB signaling pathway, and TNF signaling pathway and the inhibition of oxidative phosphorylation pathway, cardiac muscle contraction pathway, and citrate cycle pathway. Our findings provide insight into the molecular mechanism of sepsis-induced diaphragm dysfunction in mice and provide a promising new strategy for targeted treatment of diaphragm dysfunction.
Journal • IO biomarker
|
IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • SDHB (Succinate Dehydrogenase Complex Iron Sulfur Subunit B) • STAT3 (Signal Transducer And Activator Of Transcription 3) • IRF1 (Interferon Regulatory Factor 1) • COL1A1 (Collagen Type I Alpha 1 Chain)
|
IRF1 expression
6ms
The IRF1/GBP5 axis promotes osteoarthritis progression by activating chondrocyte pyroptosis. (PubMed, J Orthop Translat)
This study underscores the significance of the IRF1/GBP5 axis in NLRP3 inflammasome-mediated chondrocyte pyroptosis and osteoarthritic chondrocyte injury. Modulating IRF1 and GBP5 expression could serve as a novel therapeutic target for OA.
Journal
|
IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • IL18 (Interleukin 18) • IRF1 (Interferon Regulatory Factor 1) • GBP5 (Guanylate Binding Protein 5) • MMP9 (Matrix metallopeptidase 9) • IL1B (Interleukin 1, beta) • NLRP3 (NLR Family Pyrin Domain Containing 3) • ACAN (Aggrecan) • COL2A1 (Collagen Type II Alpha 1 Chain)
|
IRF1 expression • GBP5 expression • GBP5 overexpression
6ms
Multiple Genomic Alterations, Including a Novel AFF4::IRF1 Fusion Gene, in a Treatment-Refractory Blastic Plasmacytoid Dendritic-Cell Neoplasm: A Case Report and Literature Review. (PubMed, Int J Mol Sci)
The patient showed resistance to Tagraxofusp and Venetoclax, and he died about 16 months after diagnosis. Considering the predicted effect of the AFF4::IRF1 fusion on IRF1's antitumor effects and immune regulation, and the possibility of its relevance to the aggressive course observed in this case, we propose further evaluation of the clinical significance of this fusion in BPDCN in future cooperative group studies and the consideration of therapeutic strategies aimed at restoring IRF1-dependent antineoplastic effects in such cases.
Clinical • Review • Journal
|
MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • ASXL1 (ASXL Transcriptional Regulator 1) • TET2 (Tet Methylcytosine Dioxygenase 2) • AFF4 (AF4/FMR2 Family Member 4) • IRF1 (Interferon Regulatory Factor 1)
|
ASXL1 mutation • TET2 mutation • IRF1 expression
|
Venclexta (venetoclax) • Elzonris (tagraxofusp-erzs)
7ms
Mesenchymal stem cells (MSCs) from the mouse bone marrow show differential expression of interferon regulatory factors IRF-1 and IRF-2. (PubMed, Mol Biol Rep)
Our results suggest that IRF-1 and IRF-2 exhibit differential expression of their mRNAs and subcellular localization of the proteins in BMCs and MSCs. These cells also show differential levels of constitutive expression of IRF-1 and IRF-2 target genes. This may regulate immune-responsive properties of BMCs and MSCs through IRF-1, IRF-2-dependent gene expression and protein-protein interaction. Regulating IRF-1 and IRF-2 may be helpful for immunomodulatory functions of MSCs for cell therapy and regenerative medicine.
Preclinical • Journal
|
SOX2 • CCL2 (Chemokine (C-C motif) ligand 2) • IRF1 (Interferon Regulatory Factor 1) • MMP9 (Matrix metallopeptidase 9) • IRF2 (Interferon Regulatory Factor 2) • VCAM1 (Vascular Cell Adhesion Molecule 1) • CASP1 (Caspase 1)
|
IRF1 expression
7ms
Upregulation of the canonical signaling pathway of interferon-gamma is associated with glioblastoma progression. (PubMed, Mol Biol Rep)
IFN-γ signaling pathway is upregulated in glioblastoma, displaying pro-tumor activity. Thus, IFN-γ signaling elements may be potential biomarkers and targets for treating glioblastoma.
Journal • PD(L)-1 Biomarker • IO biomarker
|
PD-L1 (Programmed death ligand 1) • IFNG (Interferon, gamma) • IRF1 (Interferon Regulatory Factor 1) • IFNAR2 (Interferon Alpha And Beta Receptor Subunit 2) • IFNGR1 (Interferon Gamma Receptor 1)
|
IFNG expression • IRF1 expression
7ms
Cancer Differentiation Inducer Chlorogenic Acid Suppresses PD-L1 Expression and Boosts Antitumor Immunity of PD-1 Antibody. (PubMed, Int J Biol Sci)
In conclusion, through induction of differentiation, CGA appeared to suppress the expression of PD-L1 on cancer cells, effectively promoting infiltrated T cells in the tumor and boosting the antitumor effect of the anti-PD-1 antibody. Thus, CGA might serve as a promising agent to enhance anticancer immunotherapy if combined with anti-PD-1 antibodies.
Journal • PD(L)-1 Biomarker • IO biomarker
|
PD-L1 (Programmed death ligand 1) • IFNG (Interferon, gamma) • IRF1 (Interferon Regulatory Factor 1)
|
PD-L1 expression • IRF1 expression
|
chlorogenic acid
7ms
An immune gene expression risk score for distant metastases after radiotherapy for cervical cancer. (PubMed, Clin Cancer Res)
The immune metastatic risk score addresses important challenges in the treatment of cervical cancer - identifying patients at high risk of DM after radiotherapy. The findings of this study indicate that high tumor mutational burden and a 'cold', immune-excluded tumor microenvironment influence distant metastatic recurrence. Further validation of the risk score is needed.
Journal • Tumor mutational burden • PD(L)-1 Biomarker • IO biomarker
|
PD-L1 (Programmed death ligand 1) • TMB (Tumor Mutational Burden) • CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • IDO1 (Indoleamine 2,3-dioxygenase 1) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • IRF1 (Interferon Regulatory Factor 1) • STAT1 (Signal Transducer And Activator Of Transcription 1)
|
TMB-H • IRF1 expression
7ms
Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma-dependent pathogen restriction in human cells. (PubMed, Proc Natl Acad Sci U S A)
Both RNF213 mutants lost the ability to restrict growth of T. gondii, indicating that both recruitment and ubiquitination are required. Collectively, our findings establish RNF213 as a critical component of cell-autonomous immunity that is both necessary and sufficient for control of intracellular pathogens in human cells.
Journal
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IFNG (Interferon, gamma) • IRF1 (Interferon Regulatory Factor 1)
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IFNG expression • IRF1 expression
7ms
Interferon gamma immunoPET imaging to evaluate response to immune checkpoint inhibitors. (PubMed, Front Oncol)
However, compared to a 250 µg dose known to neutralize IFNγ, which diminished ICI efficacy, a tracer-equivalent 50 µg dose did not reduce ICI response rates. These results support the use of IFNγ PET as a method to monitor immune activity in situ after ICI, which may also extend to additional T cell-activating immunotherapies.
Journal • Checkpoint inhibition • PD(L)-1 Biomarker • IO biomarker
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IFNG (Interferon, gamma) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • IRF1 (Interferon Regulatory Factor 1)
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IRF1 expression