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    DRUG:

    Intuvax (ilixadencel)

    i
    Other names: allogeneic dendritic cell cancer vaccine, dendritic cell vaccine
    Associations

    News

    Trials
    Company:
    Mendus
    Drug class:
    Dendritic cell activator
    Related drugs:
    Associations

    News

    Trials
    9ms
    Proinflammatory allogeneic dendritic cells enhance the therapeutic efficacy of systemic anti-4-1BB treatment. (PubMed, Front Immunol)
    Additionally, the combined treatment resulted in a less immunosuppressive TME, indicated by decreased infiltration of myeloid-derived suppressor cells and Tregs. These findings suggest that the combination of intratumoral AlloDCs administration with systemic agonistic α4-1BB treatment can generate a synergistic anti-tumor response, thereby warranting further investigation through clinical studies.
    Journal
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    CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • CD69 (CD69 Molecule) • ITGAE (Integrin Subunit Alpha E) • ITGA1 (Integrin Subunit Alpha 1)
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    Intuvax (ilixadencel)