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DRUG:

Intuvax (ilixadencel)

i
Other names: allogeneic dendritic cell cancer vaccine, dendritic cell vaccine
Associations
Company:
Mendus
Drug class:
Dendritic cell activator
Associations
1year
Proinflammatory allogeneic dendritic cells enhance the therapeutic efficacy of systemic anti-4-1BB treatment. (PubMed, Front Immunol)
Additionally, the combined treatment resulted in a less immunosuppressive TME, indicated by decreased infiltration of myeloid-derived suppressor cells and Tregs. These findings suggest that the combination of intratumoral AlloDCs administration with systemic agonistic α4-1BB treatment can generate a synergistic anti-tumor response, thereby warranting further investigation through clinical studies.
Journal
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CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • CD69 (CD69 Molecule) • ITGAE (Integrin Subunit Alpha E) • ITGA1 (Integrin Subunit Alpha 1)
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Intuvax (ilixadencel)