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    GENE:

    INO80 (INO80 Complex ATPase Subunit)

    i
    Other names: INO80, INO80 Complex ATPase Subunit, INO80A, INO80 Complex Subunit A, KIAA1259, HINO80, INOC1, DNA Helicase-Related INO80 Complex Homolog 1, DNA Helicase-Related Protein INO80, Chromatin-Remodeling ATPase INO80, Putative DNA Helicase INO80 Complex Homolog, INO80 Complex Homolog 1 (S. Cerevisiae), INO80 Homolog (S. Cerevisiae), Homolog Of Yeast INO80, DNA Helicase INO80
    8ms
    ARNTL-mediated INO80-DHX15 axis reprograms the glycolytic metabolism and augments the progression of endometrial carcinoma. (PubMed, Cell Death Dis)
    Overexpression of either INO80 or DHX15 increased glycolytic activity and immunosuppression in ARNTL-KO EC cells. Collectively, this study suggests that the ARNTL-mediated INO80-DHX15 axis induces glycolysis and immunosuppression during EC progression.
    Journal
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    CD8 (cluster of differentiation 8) • ARNT (Aryl Hydrocarbon Receptor Nuclear Translocator) • ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator Like) • INO80 (INO80 Complex ATPase Subunit)
    over1year
    Siwu tablet attenuates high fructose-induced glomerular podocyte senescence in rats through increasing Nup155 to promote INO80 mRNA nuclear export. (PubMed, J Ethnopharmacol)
    SWT ameliorates glomerular podocyte senescence in high fructose-fed rats possibly by increasing Nup155 to promote INO80 mRNA nuclear export.
    Preclinical • Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • IL1B (Interleukin 1, beta) • INO80 (INO80 Complex ATPase Subunit)
    over1year
    Loss of Nup155 promotes high fructose-driven podocyte senescence by inhibiting INO80 mRNA nuclear export. (PubMed, J Adv Res)
    High fructose induces podocyte senescence by decreasing Nup155 to inhibit INO80 mRNA nuclear export. Ferulic acid targeting Nup155 may be a potential strategy to prevent high fructose-induced podocyte senescence.
    Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • IL1B (Interleukin 1, beta) • INO80 (INO80 Complex ATPase Subunit)