P=N/A, N=25, Completed, Children's Hospital of Fudan University | Recruiting --> Completed | Trial completion date: Jul 2026 --> Mar 2026

These findings highlight TER as a promising immune checkpoint modulator that targets the PD-1/PD-L1 axis to promote CD8+ T-cell-mediated antitumor immunity. Because of its established safety profile, TER is a readily translatable therapeutic for enhancing cancer immunotherapy in CRC.

P4, N=80, Recruiting, Amira Adel Fouly | Not yet recruiting --> Recruiting | Trial completion date: Dec 2024 --> Jun 2026 | Trial primary completion date: Oct 2024 --> Jun 2026

TP5 strengthens oncolytic virotherapy by orchestrating macrophages and CD8+ T cells to attack tumors. Its dual use, as a combination drug or engineered into viruses, offers a practical strategy to improve clinical outcomes. This approach provides a low-cost method to amplify oncolytic virus efficacy and inspires designs where single therapies mimic combination effects, advancing accessible cancer immunotherapy.

HCQ attenuated CTX-induced cellular senescence, stabilized mitochondrial membranes, decreased reactive oxygen species (ROS) production and mitochondrial DNA (mtDNA) leakage, inhibited the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling pathway, and suppressed the expression of senescence-associated secretory phenotype (SASP) factors. Collectively, our preclinical findings demonstrate that HCQ alleviates CTX-induced POF, which is associated with the mitigation of granulosa cell senescence and modulation of the mtDNA-cGAS signaling pathway.

P1/2, N=36, Recruiting, University of Zurich | Not yet recruiting --> Recruiting

P2/3, N=87, Recruiting, Amsterdam UMC Stichting | Not yet recruiting --> Recruiting

P4, N=78, Not yet recruiting, University Health Network, Toronto

P2, N=200, Not yet recruiting, Ministry of Health, Saudi Arabia

P1, N=20, Completed, University of Oklahoma | Recruiting --> Completed | N=30 --> 20

Spirulina exerts significant cardioprotective effects against CD-induced myocardial injury by modulating oxidative stress and inflammation, indicating its potential as a natural therapeutic agent for obesity-related cardiovascular disorders.

P1, N=35, Not yet recruiting, Medical University of South Carolina