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    DRUG:

    IM-4320

    i
    Other names: IM-4320, IMM-ONC-01, IMM20324
    Associations

    News

    Trials
    Company:
    Immunome
    Drug class:
    IL-38 inhibitor
    Associations

    News

    Trials
    over2years
    IL-38 blockade induces anti-tumor immunity by abrogating tumor-mediated suppression of early immune activation. (PubMed, MAbs)
    Together, our data suggest that IL-38 is expressed in a high frequency of cancer patients and allows tumor cells to suppress anti-tumor immunity. Blockade of IL-38 activity using IMM20324 can re-activate immunostimulatory mechanisms in the tumor microenvironment leading to immune infiltration, the generation of tumor-specific memory and abrogation of tumor growth.
    Journal • IO biomarker
    |
    IL1RAP (Interleukin 1 Receptor Accessory Protein)
    |
    IM-4320