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DRUG:

Rytelo (imetelstat)

i
Other names: GRN-163, GRN 140719, GRN 163-L, GRN163L, JNJ-63935937, GRN140719, GRN-719
Associations
Company:
Geron
Drug class:
Telomerase inhibitor
Associations
2ms
Targeted therapies for myelodysplastic Syndromes/Neoplasms (MDS): current landscape and future directions. (PubMed, Expert Rev Anticancer Ther)
Despite some promising results, many therapies remain in early development or have faced setbacks, emphasizing the need for a more comprehensive understanding of the disease's pathobiology. Continued research into targeted therapies, homogenous clinical trial designs, as well as increased incorporation of molecular prognostic tools and artificial intelligence into trial design are essential for developing effective treatments for MDS and improving patient outcomes.
Review • Journal
|
BCL2 (B-cell CLL/lymphoma 2) • TGFB1 (Transforming Growth Factor Beta 1)
|
Venclexta (venetoclax) • azacitidine • Reblozyl (luspatercept-aamt) • Rytelo (imetelstat)
2ms
Novel therapies for MDS and future prospects (PubMed, Rinsho Ketsueki)
This year, luspatercept, an anti-anemic agent targeting the TGFβ pathway, became available for clinical use in Japan. Various research initiatives are currently underway to develop new medicines targeting specific molecules within innate immune and inflammasome-signaling pathways, including IL-1β, CD33, TLR, IRAK4, and p38MAPK.
Journal
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CD33 (CD33 Molecule) • TGFB1 (Transforming Growth Factor Beta 1) • IL1B (Interleukin 1, beta) • IRAK4 (Interleukin 1 Receptor Associated Kinase 4)
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Reblozyl (luspatercept-aamt) • Rytelo (imetelstat)
2ms
A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients With AML, MDS or JMML That Has Come Back or Does Not Respond to Therapy (clinicaltrials.gov)
P1, N=36, Recruiting, Children's Oncology Group | Trial completion date: Apr 2026 --> Jun 2026 | Trial primary completion date: Apr 2026 --> Jun 2026
Trial completion date • Trial primary completion date • Combination therapy
|
cytarabine • methotrexate • leucovorin calcium • fludarabine IV • Rytelo (imetelstat) • Starasid (cytarabine ocfosfate)
2ms
Obesity-Senescence-Breast Cancer: Clinical Presentation of a Common Unfortunate Cycle. (PubMed, Adv Exp Med Biol)
In this review, interlinked molecular mechanisms are looked over between the telomere length, lipotoxicity/glycolipotoxicity, and cellular senescence in the context of estrogen receptor alpha-positive (ERα+) postmenopausal breast cancers in obese women. Furthermore, the effect of the potential drugs, which are used for direct inhibition of telomerase and the inhibition of human telomerase reverse transcriptase (hTERT) or human telomerase RNA promoters as well as approved adjuvant endocrine therapies, the selective estrogen receptor modulator and selective estrogen receptor down-regulators are discussed.
Review • Journal
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TERT (Telomerase Reverse Transcriptase) • LEP (Leptin)
|
fulvestrant • Rytelo (imetelstat)
3ms
Advancements in Telomerase-Targeted Therapies for Glioblastoma: A Systematic Review. (PubMed, Int J Mol Sci)
Imetelstat, the only telomerase inhibitor that has undergone clinical trials, has demonstrated efficacy in various cancers, but its efficacy in GBM has been limited...Future strategies may include Telomerase-based vaccines and multi-target inhibitors, which may provide more effective treatments when combined with a better understanding of telomere dynamics and tumor biology. These treatments have the potential to be integrated with existing ones and to improve the outcomes for patients with GBM.
Review • Journal
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TERT (Telomerase Reverse Transcriptase)
|
Rytelo (imetelstat)
3ms
Trial completion date • Trial primary completion date
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hydroxyurea • Rytelo (imetelstat)
3ms
Trial initiation date • Combination therapy
|
cytarabine • methotrexate • leucovorin calcium • fludarabine IV • Rytelo (imetelstat) • Starasid (cytarabine ocfosfate)
4ms
Enrollment open
|
cytarabine • methotrexate • leucovorin calcium • fludarabine IV • Rytelo (imetelstat) • Starasid (cytarabine ocfosfate)
5ms
IMpress: Study to Evaluate Imetelstat in Patients With High-Risk MDS or AML Failing HMA-based Therapy (clinicaltrials.gov)
P2, N=23, Active, not recruiting, GCP-Service International West GmbH | Recruiting --> Active, not recruiting | N=46 --> 23
Enrollment closed • Enrollment change
|
Rytelo (imetelstat)
6ms
Trial completion date • Trial primary completion date
|
hydroxyurea • Rytelo (imetelstat)
6ms
IMproveMF: A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of Imetelstat in Combination With Ruxolitinib in Participants With Myelofibrosis (clinicaltrials.gov)
P1, N=41, Recruiting, Geron Corporation | Trial completion date: Dec 2026 --> Aug 2027 | Trial primary completion date: Jun 2025 --> Feb 2026
Trial completion date • Trial primary completion date • Combination therapy
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Jakafi (ruxolitinib) • Rytelo (imetelstat)
6ms
Treatment of Anemia in Lower-Risk Myelodysplastic Syndrome. (PubMed, Curr Treat Options Oncol)
The treatment landscape of LR-MDS with anemia is also rapidly evolving; we review the role of supportive care, erythropoietin stimulating agents, lenalidomide, luspatercept, hypomethylating agents (HMAs), and immunosuppressive therapy (IST) in the management of LR-MDS with anemia. For those without previous luspatercept exposure it can be considered particularly if there is an SF3B1 mutation or the presence of ring sideroblasts. Other options include HMAs or IST; the Phase III IMERGE trial supports the efficacy of the telomerase inhibitor imetelstat in this setting and this may become a standard option in the future as well.
Review • Journal
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SF3B1 (Splicing Factor 3b Subunit 1)
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lenalidomide • Reblozyl (luspatercept-aamt) • Rytelo (imetelstat)
9ms
IMpress: Study to Evaluate Imetelstat in Patients With High-Risk MDS or AML Failing HMA-based Therapy (clinicaltrials.gov)
P2, N=46, Recruiting, GCP-Service International West GmbH | Trial primary completion date: Jan 2024 --> Feb 2025
Trial primary completion date
|
Rytelo (imetelstat)
10ms
New P1 trial
|
cytarabine • methotrexate • leucovorin calcium • fludarabine IV • Rytelo (imetelstat) • Starasid (cytarabine ocfosfate)
11ms
Trial primary completion date
|
Rytelo (imetelstat)
12ms
Treatment of anemia in myelofibrosis: focusing on Novel Therapeutic Options. (PubMed, Expert Opin Investig Drugs)
This review summarizes novel and promising treatments for anemia in myelofibrosis including transforming growth factor-β inhibitors luspatercept and KER-050, JAK inhibitors momelotinib, pacritinib, and jaktinib, BET inhibitors pelabresib and ABBV-744, antifibrotic PRM-151, BCL2/BCL-XL inhibitor navitoclax, and telomerase inhibitor imetelstat. Standard approaches to treat myelofibrosis-related anemia have limited efficacy and are associated with toxicity. New drugs have shown positive results in myelofibrosis-associated anemia when used alone or in combination.
Review • Journal
|
BCL2 (B-cell CLL/lymphoma 2) • BCL2L1 (BCL2-like 1)
|
navitoclax (ABT 263) • ABBV-744 • Reblozyl (luspatercept-aamt) • Vonjo (pacritinib) • Ojjaara (momelotinib) • pelabresib (DAK539) • Rytelo (imetelstat) • elritercept (KER-050) • zinpentraxin alfa (RG6354)
12ms
Improvement of Patient-Reported Outcomes Among Heavily Pretreated Patients with Lower-Risk Myelodysplastic Syndromes and High Transfusion Burden Treated with Imetelstat on the IMerge Phase 3 Trial (ASH 2023)
Findings from multiple validated PRO questionnaires consistently show that patients with red blood cell transfusion-dependent LR-MDS enrolled into the IMerge randomized trial who were treated with imetelstat reported improved fatigue, dyspnea, and QUALMS composite scores (total and physical burden) compared with those in the placebo group. These data indicate that, in addition to improving transfusion burden in patients with LR-MDS, imetelstat targets multiple core symptoms of LR-MDS simultaneously, also improving PROs.
Clinical • P3 data • Patient reported outcomes
|
Rytelo (imetelstat)
1year
The telomerase inhibitor imetelstat differentially targets JAK2V617F versus CALR mutant myeloproliferative neoplasm cells and inhibits JAK-STAT signaling. (PubMed, Front Oncol)
Hence, our data demonstrate that imetelstat reduces TL and targets JAK/STAT signaling, particularly in CALR-mutated cells. Although the exact patient subpopulation who will benefit most from imetelstat needs to be defined, our data propose that CALR-mutated clones are highly vulnerable.
Journal
|
KRAS (KRAS proto-oncogene GTPase) • JAK2 (Janus kinase 2) • STAT3 (Signal Transducer And Activator Of Transcription 3) • CD34 (CD34 molecule) • CALR (Calreticulin) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1)
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KRAS mutation • JAK2 V617F • STAT3 expression • CALR mutation
|
Rytelo (imetelstat)
1year
Durable Continuous Transfusion Independence (TI) with Imetelstat in IMerge Phase 3 for Patients with Heavily Transfused Non-Del(5q) Lower-Risk Myelodysplastic Syndromes (LR-MDS) Relapsed/Refractory (R/R) to or Ineligible for Erythropoiesis-Stimulating Agents (ESAs) (ASH 2023)
In the IMerge phase 3 trial, imetelstat produced higher rates of TI for ≥8 weeks, ≥24 weeks, and ≥1 year (39.8%, 28.0%, and 17.8%) than placebo (15.0%, 3.3%, and 1.7%) in pts with non-del(5q) LR-MDS that was RBC-TD, R/R to/ineligible for ESAs, and naïve to lenalidomide or hypomethylating agents (HMAs; Platzbecker et al. Treatment with imetelstat resulted in ≥1-year sustained, continuous TI in 17.8% of pts in the IMerge phase 3 trial. In this ESA-R/R/ineligible population with a high prior transfusion burden, a reduction to 0 RBC transfusions for ≥1 year represents an opportunity to achieve relief from iron overload and other transfusion associated complications, and decreased demand on already limited blood product supply. Furthermore, durable TI and meaningful reductions in mutational burden suggest imetelstat may have disease-modifying activity.
Clinical • P3 data • Tumor mutational burden
|
TMB (Tumor Mutational Burden) • DNMT3A (DNA methyltransferase 1) • JAK2 (Janus kinase 2) • SF3B1 (Splicing Factor 3b Subunit 1) • ASXL1 (ASXL Transcriptional Regulator 1) • TET2 (Tet Methylcytosine Dioxygenase 2)
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DNMT3A mutation • ASXL1 mutation • TET2 mutation • SF3B1 mutation • JAK2 mutation
|
lenalidomide • Rytelo (imetelstat)
1year
Impact of Mutational Status on Clinical Response to Imetelstat in Patients with Lower-Risk Myelodysplastic Syndromes in the IMerge Phase 3 Study (ASH 2023)
Higher RBC-TI rates were observed in patients with various baseline mutational profiles treated with imetelstat compared with placebo in IMerge. While the sample size for specific mutations was small, consistent with the observation that patients with LR-MDS have a low number of specific mutations, TI responses in patients receiving imetelstat occurred regardless of the presence of mutations associated with poor prognosis or the number of mutations. Imetelstat showed comparable TI rates across different molecularly defined subgroups, suggesting that clinical benefit of imetelstat in patients with LR-MDS is independent of the underlying molecular pattern.
Clinical • P3 data
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TP53 (Tumor protein P53) • DNMT3A (DNA methyltransferase 1) • RUNX1 (RUNX Family Transcription Factor 1) • SF3B1 (Splicing Factor 3b Subunit 1) • ASXL1 (ASXL Transcriptional Regulator 1) • TET2 (Tet Methylcytosine Dioxygenase 2) • ETV6 (ETS Variant Transcription Factor 6) • CUX1 (cut like homeobox 1)
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TP53 mutation • DNMT3A mutation • RUNX1 mutation • ASXL1 mutation • TET2 mutation • SF3B1 K700E • ETV6 mutation • CUX1 mutation
|
Rytelo (imetelstat)
1year
FORTITUDE: A Phase 2 Open-Label Study in Progress to Evaluate Etavopivat for the Treatment of Anemia in Patients with Lower-Risk Myelodysplastic Syndromes (ASH 2023)
Erythropoiesis-stimulating agents and other drugs, including lenalidomide, luspatercept and imetelstat (an investigational product), can lead to RBC transfusion independence and improve Hb levels in many patients; however, responses are generally transient and novel treatments are needed for this population...Additional exclusion criteria include prior treatment with azacitidine; decitabine; erythropoietin, other hematopoietic growth factor treatment or lenalidomide within 30 days of Day 1 or anticipated to be required during the study; and luspatercept within 30 days of Day 1 for NTD patients and within 16 weeks of Day 1 for TD patients...Summary: Etavopivat is a novel, investigational, once-daily, selective PKR activator with the potential to improve RBC health and lifespan. This phase 2 study will assess the safety of etavopivat and its impact on Hb levels and RBC transfusion burden in patients with LR-MDS and anemia.
Clinical • P2 data
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TP53 (Tumor protein P53)
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lenalidomide • azacitidine • decitabine • Reblozyl (luspatercept-aamt) • Rytelo (imetelstat)
1year
Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia. (PubMed, Nat Cancer)
Pharmacological inhibition of ferroptosis diminishes imetelstat efficacy. We leverage these mechanistic insights to develop an optimized therapeutic strategy using oxidative stress-inducing chemotherapy to sensitize patient samples to imetelstat causing substantial disease control in AML.
Journal
|
NRAS (Neuroblastoma RAS viral oncogene homolog)
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NRAS mutation
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Rytelo (imetelstat)
1year
Updates on risk stratification and management of lower-risk myelodysplastic syndromes/neoplasms. (PubMed, Future Oncol)
A subset of these patients with del(5q) may do better with lenalidomide. Recently, in randomized trials, luspatercept has shown better responses compared with ESAs in treatment-naive patients and imetelstat in patients refractory to ESAs. Other evaluated novel compounds (fostamatinib, H3B-880, roxadustat, pyruvate kinase receptor activator) have not yet shown meaningful efficacy...While lower-risk myelodysplastic syndromes/neoplasms tend to have an indolent course, a subset of them has a dismal prognosis. Improving prognostication and serial monitoring will help in identifying high-risk patients for appropriate management.
Review • Journal
|
Chr del(5q)
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lenalidomide • Reblozyl (luspatercept-aamt) • Tavalisse (fostamatinib) • Evrenzo (roxadustat) • Rytelo (imetelstat)
1year
Disease Modifying Activity of Imetelstat in Patients With Heavily Transfused Non‑Del(5q) Lower‑Risk Myelodysplastic Syndromes Relapsed/Refractory/Ineligible for Erythropoiesis‑Stimulating Agents in IMerge Phase 3 (SOHO 2023)
Patients: Heavily RBC transfusion-dependent (TD) non-del(5q) LR-MDS; relapsed/refractory/ineligible for erythropoiesis-stimulating agents (ESA); naïve to lenalidomide and hypomethylating agents. Imetelstat may improve the ineffective erythropoiesis and thus alter the underlying biology of disease in patients with LR- MDS. Author Contributions: AMZ and RSK contributed equally.
Clinical • P3 data
|
DNMT3A (DNA methyltransferase 1) • SF3B1 (Splicing Factor 3b Subunit 1) • ASXL1 (ASXL Transcriptional Regulator 1) • TET2 (Tet Methylcytosine Dioxygenase 2)
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DNMT3A mutation • ASXL1 mutation • TET2 mutation
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lenalidomide • Rytelo (imetelstat)
over1year
Telomerase-Targeted Therapies in Myeloid Malignancies. (PubMed, Blood Adv)
We go on to discuss the development of telomere and telomerase targeted therapeutic candidates within the realm of myeloid malignancies. We overview all mechanisms of targeting telomerase that are currently in development with a particular focus on imetelstat, an oligonucleotide with direct telomerase inhibitory properties that has advanced the furthest in clinical development and has demonstrated promising data in multiple myeloid malignancies.
Journal
|
Rytelo (imetelstat)
over1year
Management of Patients with Lower-Risk Myelodysplastic Neoplasms (MDS). (PubMed, Curr Oncol)
The recent approval of luspatercept and decitabine/cedazuridine have added on to the current armamentarium of erythropoietic stimulating agents and lenalidomide (for MDS with isolated deletion 5q). Several newer agents are being evaluated in phase 3 clinical trials for this group of patients, such as imetelstat and oral azacitidine. This review provides a summary of the classification systems, the prognostic scores and clinical management of patients with lower risk MDS.
Review • Journal
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lenalidomide • Inqovi (decitabine/cedazuridine) • Onureg (azacitidine oral) • Reblozyl (luspatercept-aamt) • Rytelo (imetelstat)
over1year
Treatment of lower risk myelodysplastic syndromes (PubMed, Bull Cancer)
We can retain luspatercept for MDS with excess ring of sideroblasts, lenalidomide, and some molecules currently being tested such as imetelstat or roxedustat. However, the search for new therapeutic options for ESA-resistant low-risk MDS remains necessary. We can use androgenotherapy or TPO agonists in limited access for symptomatic thrombocytopenia.
Review • Journal
|
lenalidomide • Reblozyl (luspatercept-aamt) • Rytelo (imetelstat)
over1year
New trial
|
Rytelo (imetelstat)
over1year
Raising the bar for lower-risk myelodysplastic syndromes. (PubMed, Leuk Lymphoma)
Currently, erythropoiesis stimulating agents (recombinant erythropoietin), erythroid maturation agents (luspatercept), disease modifying agents (lenalidomide) and hypomethylating agents are the agents of choice in the treatment of LR-MDS. This review will discuss the current treatment standards, meaningful clinical outcomes, and emerging therapies in LR-MDS.
Journal
|
lenalidomide • Reblozyl (luspatercept-aamt) • Rytelo (imetelstat)
over1year
IMpress: Study to Evaluate Imetelstat in Patients With High-Risk MDS or AML Failing HMA-based Therapy (clinicaltrials.gov)
P2, N=46, Recruiting, GCP-Service International West GmbH | Not yet recruiting --> Recruiting
Enrollment open
|
Rytelo (imetelstat)
over1year
Novel Approaches and Future Directions in Myelodysplastic Syndrome Treatment. (PubMed, Cancer J)
Although anemic patients with lower-risk MDS are currently treated with an erythropoiesis-stimulating agent, luspatercept, and transfusions, the telomerase inhibitor imetelstat and the hypoxia-inducible factor α inhibitor roxadustat have shown encouraging early results and are now in phase III clinical trials. For higher-risk MDS patients, hypomethylating agent monotherapy continues to be the standard of care. However, with various novel hypomethylating agent-based combination therapies in advanced clinical testing and an increased emphasis on individualized biomarker-driven treatment decisions, the standard therapy paradigms might change in the future.
Journal
|
Reblozyl (luspatercept-aamt) • Evrenzo (roxadustat) • Rytelo (imetelstat)
over1year
IMpress: Study to Evaluate Imetelstat in Patients With High-Risk MDS or AML Failing HMA-based Therapy (clinicaltrials.gov)
P2, N=46, Not yet recruiting, GCP-Service International West GmbH | Initiation date: Dec 2022 --> May 2023
Trial initiation date
|
Rytelo (imetelstat)
over1year
DISEASE MODIFYING ACTIVITY OF IMETELSTAT IN PATIENTS WITH HEAVILY TRANSFUSED NON-DEL(5Q) LOWER-RISK MYELODYSPLASTIC SYNDROMES RELAPSED/REFRACTORY TO ERYTHROPOIESIS STIMULATING AGENTS IN IMERGE PHASE 3 (EHA 2023)
Patients with heavily red blood cell (RBC) transfusion-dependent (TD) erythropoiesis stimulating agent (ESA) relapsed/refractory (R/R) or ineligible non-del(5q) LR-MDS naive to lenalidomide and hypomethylating agents (len/HMA) received 2-hr infusions of imetelstat 7.5 mg/kg or placebo every 4 weeks. In the phase 3 IMerge study, heavily RBC TD ESA R/R/ineligible non-del(5q) LR-MDS patients naive to len/HMA treated with imetelstat experienced more cytogenetic response and reduction in SF3B1 , TET2 , DNMT3A, and ASXL1 mutational burden compared with placebo. Furthermore, SF3B1 VAF reduction correlated with clinically meaningful endpoints of increased hemoglobin and TI duration. These data, taken together with robust rates of TI that are continuous and durable, may indicate improvement of the ineffectiveerythropoiesis characteristic of LR-MDS and suggest imetelstat may alter the underlying biology of disease in these patients.
Clinical • P3 data • Tumor mutational burden
|
TMB (Tumor Mutational Burden) • DNMT3A (DNA methyltransferase 1) • SF3B1 (Splicing Factor 3b Subunit 1) • ASXL1 (ASXL Transcriptional Regulator 1) • TET2 (Tet Methylcytosine Dioxygenase 2)
|
DNMT3A mutation • ASXL1 mutation • TET2 mutation • SF3B1 mutation
|
lenalidomide • Rytelo (imetelstat)
over1year
ANALYSIS OF PATIENT-REPORTED FATIGUE IN IMERGE PH3 TRIAL OF IMETELSTAT VS PLACEBO IN HEAVILY TRANSFUSED NON-DEL(5Q) LOWER-RISK MYELODYSPLASTIC SYNDROMES R/R TO ERYTHROPOIESIS STIMULATING AGENTS (EHA 2023)
In the IMerge Phase 3 (Ph3) study (NCT02598661), imetelstat, a first-in-class telomerase inhibitor, demonstrated statistically significant and meaningfully improved 8- and 24-wk transfusion independence (TI) rates, durable TI, and increased hemoglobin levels compared with placebo in heavily red blood cell (RBC) transfusion-dependent (TD) non-del(5q) LR-MDS pts who were ineligible/relapsed/refractory to ESA and naive to lenalidomide/hypomethylating agents. In this heavily TD population, both imetelstat- and placebo-treated pts reported similar rates of deterioration in fatigue, suggesting imetelstat did not worsen the rate of deterioration, which has been reported with other available treatments. After 12 wks, greater improvement in fatigue was reported with imetelstat compared to placebo; pts on imetelstat were more likely to have sustained meaningful improvement infatigue and quicker to experience it. A significant association between TI and HI-E responses and sustained meaningful improvement in fatigue support the clinical benefit of imetelstat treatment.
Clinical
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lenalidomide • Rytelo (imetelstat)
over1year
CONTINUOUS TRANFUSION INDEPENDENCE WITH IMETELSTAT IN HEAVILY TRANSFUSED NON-DEL(5Q) LOWER-RISK MYELODYSPLASTIC SYNDROMES RELAPSED/REFRACTORY TO ERYTHROPOIESIS STIMULATING AGENTS IN IMERGE PHASE 3 (EHA 2023)
In IMerge Phase 2 (NCT02598661), treatment with imetelstat, a telomerase inhibitor, resulted in prolonged, durable transfusion independence (TI) across a broad range of heavily RBC TD ESA relapsed/refractory non-del(5q) LR-MDS patients (pts) naive to lenalidomide and hypomethylating agents (len/HMA). Imetelstat demonstrated statistically significant and clinically meaningful efficacy with robust 8-wk, 24-wk, and 1-yr TI rates and durable continuous TI. For this LR-MDS patient population, almost one fifth of imetelstat-treated pts achieved continuous TI for ≥1 yr, representing substantial relief from transfusion- associated complications. VAF reduction and its correlation to clinical endpoints, including durable TI, supportimetelstat's disease-modifying potential.
P3 data • Tumor mutational burden
|
TMB (Tumor Mutational Burden) • DNMT3A (DNA methyltransferase 1) • SF3B1 (Splicing Factor 3b Subunit 1) • ASXL1 (ASXL Transcriptional Regulator 1) • TET2 (Tet Methylcytosine Dioxygenase 2)
|
lenalidomide • Rytelo (imetelstat)
2years
Imetelstat Achieved Prolonged, Continuous Transfusion Independence (TI) in Patients with Heavily Transfused Non-Del(5q) Lower-Risk Myelodysplastic Syndrome (LR-MDS) Relapsed/Refractory (R/R) to Erythropoiesis Stimulating Agents (ESAs) within the IMerge Phase 2 Study (ASH 2022)
Treatment with imetelstat achieved >1 year sustained, continuous TI in 29% of RBC TD, ESA-R/R LR-MDS patients who were non-del(5q) and lenalidomide/HMA-naïve and was safe and well tolerated. Of the overall population, attainment of 24-week TI was indicative of a likelihood to achieve TI >1 year. In this ESA-R/R population with a high transfusion burden prior to treatment, a decrease to zero RBC transfusions for a period >1 year represents relief from iron overload and other transfusion-associated complications, and decreased demand on health care resources.
Clinical • P2 data • Tumor Mutational Burden
|
TMB (Tumor Mutational Burden) • TERT (Telomerase Reverse Transcriptase) • SF3B1 (Splicing Factor 3b Subunit 1)
|
lenalidomide • Rytelo (imetelstat)
over2years
The clinical dilemma of JAK inhibitor failure in myelofibrosis: Predictive characteristics and outcomes. (PubMed, Cancer)
Two Janus-associated kinase inhibitors (JAKi) (initially ruxolitinib and, more recently, fedratinib) have been approved as treatment options for patients who have intermediate-risk and high-risk myelofibrosis (MF), with pivotal trials demonstrating improvements in spleen volume, disease symptoms, and quality of life. To address such a high unmet therapeutic need, various non-JAKi agents are being actively explored (in combination with ruxolitinib in first-line or salvage settings and/or as monotherapy in JAKi-pretreated patients) in phase 3 clinical trials, including pelabresib (a bromodomain and extraterminal domain inhibitor), navitoclax (a B-cell lymphoma 2/B-cell lymphoma 2-xL inhibitor), parsaclisib (a phosphoinositide 3-kinase inhibitor), navtemadlin (formerly KRT-232; a murine double-minute chromosome 2 inhibitor), and imetelstat (a telomerase inhibitor). The breadth of data expected from these trials will provide insight into the ability of non-JAKi treatments to modify the natural history of MF.
Review • Journal
|
BCL2 (B-cell CLL/lymphoma 2)
|
Jakafi (ruxolitinib) • navitoclax (ABT 263) • navtemadlin (KRT-232) • parsaclisib (INCB50465) • Inrebic (fedratinib) • pelabresib (DAK539) • Rytelo (imetelstat)
almost3years
​​​​​INCREASED DIAGNOSTIC TELOMERE LENGTH ASSOCIATES WITH HIGHER RELAPSE RATES IN TRANSPLANTED ACUTE MYELOID LEUKEMIA PATIENTS (EBMT 2022)
 Here we established a sensitive ddPCR assay to quantify mean TL in AML patients, which could be used in future clinical research requiring a high sample throughput. Our data suggest telomere lengthening at time of diagnosis to be a common phenomenon associated with a higher burden of immature CD34+/CD38- cells and a more aggressive disease phenotype, reflected by a higher relapse rate after HSCT. Shorter mean TL in remission could be due to either therapeutic toxicity or depletion of AML blasts with prolonged telomeres.
Clinical • IO biomarker
|
IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • CD38 (CD38 Molecule) • CD34 (CD34 molecule)
|
IDH1 mutation
|
Rytelo (imetelstat)
3years
Imetelstat Significantly Reduces Leukemia Stem Cells in Patient-Derived Xenograft Models of Pediatric AML (ASH 2021)
Mice receiving standard chemotherapy consisting of cytarabine and daunorubicin or azacitidine showed prolonged survival compared to the untreated mice. These results were corroborated in vivo in two distinct PDX models which showed reduced LSC population and increased median survival in mice with imetelstat treatment. Combining imetelstat with chemotherapy or azacitidine further enhanced activity against LSCs, suggesting imetelstat could represent an effective therapeutic strategy for pediatric AML.
Preclinical • IO biomarker
|
CD38 (CD38 Molecule) • CD34 (CD34 molecule) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C)
|
cytarabine • azacitidine • daunorubicin • Rytelo (imetelstat)