Cells were pretreated with simvastatin or lovastatin before GSK101...Herein, we showed that statins can modulate gliosis and TNF-α expression in Müller cells, protecting RGCs. These data further support the neuroprotective effect of statins, promoting them as a potential treatment for glaucoma.

12 months ago

Journal

TNFA (Tumor Necrosis Factor-Alpha) • TRPV4 (Transient Receptor Potential Cation Channel Subfamily V Member 4)

IMCnyeso • lovastatin

almost3years

Safety and Efficacy of IMCnyeso in Advanced NY-ESO-1 and/or LAGE-1A Positive Cancers (clinicaltrials.gov)

P1/2, N=29, Terminated, Immunocore Ltd | N=63 --> 29

almost 3 years ago

Enrollment change

CTAG1B (Cancer/testis antigen 1B) • CTAG2 (Cancer/testis antigen 2)

HLA-A*02:01

IMCnyeso

over3years

Safety and Efficacy of IMCnyeso in Advanced NY-ESO-1 and/or LAGE-1A Positive Cancers (clinicaltrials.gov)

P1/2, N=63, Terminated, Immunocore Ltd | Active, not recruiting --> Terminated; Strategic decision to stop development and not based on any safety concerns

over 3 years ago

Clinical • Trial termination

CTAG1B (Cancer/testis antigen 1B) • CTAG2 (Cancer/testis antigen 2)

HLA-A*02:01

IMCnyeso

over3years

Safety and Efficacy of IMCnyeso in Advanced NY-ESO-1 and/or LAGE-1A Positive Cancers (clinicaltrials.gov)

P1/2, N=63, Active, not recruiting, Immunocore Ltd | Recruiting --> Active, not recruiting

over 3 years ago

Clinical • Enrollment closed

CTAG1B (Cancer/testis antigen 1B) • CTAG2 (Cancer/testis antigen 2)

IMCnyeso