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DRUG:

IM96 CAR-T cells

i
Other names: IM96 CAR-T cells
Company:
Beijing Imunopharm
Drug class:
GUCY2C-targeted CAR-T immunotherapy
over1year
Phase I study of GCC CAR-T therapy IM96 in patients with advanced colorectal cancer (ESMO 2023)
Pts were pre-treated with fludarabine and cyclophosphamide, and received a single infusion of IM96 at the dose of 3×108 (DL1), 6×108 (DL2), 12×108 (DL3), or 20×108 (DL4) CAR-T cells...The clinical response is correlated with tumor GCC expression, infusion dose, and CAR-T expansion level. This study is ongoing, and dose extensive investigation will also be performed.
Clinical • P1 data • IO biomarker • Metastases
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IL6 (Interleukin 6)
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cyclophosphamide • fludarabine IV • IM96 CAR-T cells