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    BIOMARKER:

    IL7R overexpression

    i
    Other names: IL7R, Interleukin 7 Receptor, Interleukin-7 Receptor Subunit Alpha, IL-7 Receptor Subunit Alpha, L-7R Subunit Alpha, CD127 Antigen, IL-7R-Alpha, Interleukin 7 Receptor Isoform H5-6, Interleukin 7 Receptor Alpha Chain, CDW127, CDw127, IL-7RA, CD127, IL7RA, ILRA
    Entrez ID:
    3575
    Related biomarkers:
    Expression
    Mutation
    Fusion
    over1year
    IL7R TME expression correlates with immunotherapy response and is associated with T-cell stemness with decreased apoptosis (SITC 2022)
    Conclusions Altogether, our data show that IL7R pathway expression in TILs and tumor-specific Tcell clonotypes are predictive of long-term ICI clinical response. Redirecting IL7 on PD1+Tcells provides stemness, proliferative and survival signals to tumor-specific Tcells capable to induce durable response.
    PD(L)-1 Biomarker • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • IFNG (Interferon, gamma) • IL2 (Interleukin 2) • IL7R (Interleukin 7 Receptor) • IL15 (Interleukin 15) • IL7 (Interleukin 7) • TCF7 (Transcription Factor 7)
    |
    BCL2 expression • IL7R expression • IL7R overexpression