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    BIOMARKER:

    IL32 overexpression

    i
    Other names: IL32, Interleukin 32, TAIF, NK4, Tumor Necrosis Factor Alpha-Inducing Factor, Natural Killer Cell Transcript 4, Natural Killer Cells Protein 4, Interleukin-32, TAIFb, TAIFd, Interleukin-32 Small, Interleukin-32 Theta, Interleukin-32 Eta, IL-32alpha, IL-32delta, IL-32gamma, IL-32beta, TAIFa, TAIFc
    Entrez ID:
    9235
    almost2years
    IL32 overexpression is driven by DNA hypomethylation and contributes to an extracellular matrix (ECM) remodeling phenotype in EpCAM-/CD49f-enriched breast cancer cells. (PubMed, FASEB J)
    Additionally, expression of the beta-transcript could be suppressed when CSC-enriched cells were treated with the BET-bromodomain inhibitor JQ1...Additionally, IL32 suppression decreased the invasiveness of SUM159PT based on an ECM-matrix cell invasion assay. Collectively, our results reflect the notion that differential IL32 expression by promoter hypomethylation in breast CSCs plays a role in ECM remodeling for purposes of breast cancer cell invasion and metastasis.
    Journal • Epigenetic controller
    |
    EPCAM (Epithelial cell adhesion molecule) • IL32 (Interleukin 32) • ITGA6 (Integrin, alpha 6)
    |
    IL32 overexpression
    |
    JQ-1
    2years
    Extracellular vesicle IL-32 promotes the M2 macrophage polarization and metastasis of esophageal squamous cell carcinoma via FAK/STAT3 pathway. (PubMed, J Exp Clin Cancer Res)
    Taken together, our results indicated that EV-IL-32 derived from ESCC cell line could be internalized by macrophages and lead to M2 macrophage polarization via FAK-STAT3 pathway, thus promoting the metastasis of ESCC. These findings indicated that IL-32 could serve as a potential therapeutic target in patients with ESCC.
    Journal
    |
    IL32 (Interleukin 32)
    |
    IL32 overexpression