IL2RA (Interleukin 2 receptor, alpha)

Patients admitted for IRAEs tended to have high-grade toxicity and high mortality rates, highlighting the need for timely diagnostics and treatment. A cytokine signature of elevated CRP, CD25, IL-10, and IL-6 was identified and associated with IRAEs.

The Fc-optimized anti-CD276 antibody 8H8_SDIE effectively enhanced NK cell reactivity against CD276-positive CRC cells and induced tumor cell lysis in vitro. These findings suggest that 8H8_SDIE holds potential as a novel immunotherapeutic candidate for CRC, particularly for patients with microsatellite-stable disease, and warrants further evaluation in advanced preclinical and future clinical studies.

We identified a feasible method to activate CD56+ cells and evaluate the safety of their infusion in patients. Despite the value of activating CD56+ cells with IL-15, further studies with larger sample sizes are needed to confirm and validate the current hypothesi (registration number: IRCT20230801058996N2).

Pharmacokinetic-receptor occupancy (PK/RO) modeling showed that by masking wild-type IL2 in the periphery, WTX-124 produces high RO on TILs but low RO on peripheral lymphocytes, unlike non-alpha IL2s. These findings therefore identify the conditional activation of wild-type IL2 as a promising engineering strategy to improve IL2 tolerability without compromising its antitumor activity.

EVs enriched in platelet (CD49e) and endothelial (CD31) markers were associated with corticosteroid response, whereas EVs enriched with endothelial (CD105 and CD146) and B lymphocyte (CD19) markers were associated with mortality. Overall, EVs enriched in endothelial and monocyte markers may represent a candidate non-invasive tool for predicting corticosteroid response and mortality in AH, aiding risk stratification and early identification of non-responders for timely transplant evaluation.

Our study demonstrates that a CLDN18.2-targeting DC vaccine can effectively induce potent antigen-specific CTL responses and elicit significant antitumor immunity in a preclinical model. These findings provide a strong rationale for the clinical development of CLDN18.2-directed DC-based immunotherapy for gastric cancer.

Patients with high IL-2R and low PNI shared common characteristics, including advanced age, higher Ann Arbor stage, more frequent B symptoms, higher IPI scores, a higher proportion of intermediate-to-high-risk patients, poorer performance status, and shorter overall survival (OS) and progression-free survival (PFS). Multivariate analysis indicated that IL-2R > 1,202 U/mL and PNI ≤ 44.65 were independent risk factors for poor PFS and OS in newly diagnosed DLBCL patients.

VCAN limits T cell trafficking and effector function and its proteolysis correlates with an effector phenotype of circulating CD8+ T cells, greater tumor infiltrating lymphocytes and improved clinical outcomes with this immunotherapy-based clinical trial treatment.

Four injections of a CD25 antibody-drug conjugate induced complete remission in mice transplanted with PDX refractory leukemia. These findings highlight the dependency of tyrosine kinase-driven leukemias on robust feedback control and the role of PKCδ and CD25 in assembling its components.

Here, we report atypical clinicopathological features observed in the case of CEL. These findings have potential biological, diagnostic, and prognostic relevance, emphasizing the need for further studies to elucidate their clinical significance and to expand the understanding of this disease.

Today, this molecular precision drives broad clinical translation, ranging from Treg-based therapies in autoimmunity and transplantation to targeted Treg modulation in cancer immunotherapy. This Short Review traces the trajectory-from controversy to molecular definition-and frames a forward path for context-dependent modulation of Tregs in clinical medicine.

Furthermore, donors with higher baseline percentages of γδ T cells, CD19+ B cells, CD4 T cells, Vδ2 Naïve, Vδ2 TemRA, CD3+CD25+, and Vδ2+CD25+; and low Effector Memory CD3+ and Vδ1+ T cells were associated with fewer Cytomegalovirus (CMV) reactivation in their recipients. The present study underscores the importance of compositional analysis of immune cells in both recipients and donors as a discerning predictive tool for anticipating long-term clinical outcomes following allogeneic HSCT and highlights the need for future validation in larger cohorts.