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    BIOMARKER:

    IL21R overexpression

    i
    Other names: IL21R, Interleukin 21 Receptor, CD360, Novel Interleukin Receptor, Interleukin-21 Receptor, IL-21 Receptor, NILR, CD360 Antigen, IL-21R, IMD56
    Entrez ID:
    50615
    almost2years
    Interleukin-21 receptor signaling promotes metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma by inducing immunosuppressive IgA+ B cells. (PubMed, Mol Cancer)
    IL-21R plays a cancer-promoting role by inducing IgA+ B cells in MASH-driven hepatocarcinogenesis. Targeting IL-21R signaling represents a potential therapeutic strategy for cancer therapy.
    Journal
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    CD8 (cluster of differentiation 8) • STAT1 (Signal Transducer And Activator Of Transcription 1) • IL21 (Interleukin 21) • IL21R (Interleukin 21 Receptor) • FOS (Fos Proto-Oncogene AP-1 Transcription Factor Subunit 2) • JUN (Jun proto-oncogene)
    |
    IL21R overexpression