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    BIOMARKER:

    IL17RA underexpression

    i
    Other names: IL17RA, Interleukin 17 Receptor A, IL-17RA, CDw217, HIL-17R, CD217, IL17R, Interleukin-17 Receptor A, IL-17 Receptor A, Interleukin 17 Receptor, CD217 Antigen, CANDF5, IMD51
    Entrez ID:
    23765
    Related biomarkers:
    Mutation
    almost2years
    Decreased interleukin-17RA expression is associated with good prognosis in patients with colorectal cancer and inhibits tumor growth and vascularity in mice. (PubMed, Cancer Med)
    Reduced IL-17RA expression also suppressed cellular proliferation, migration, and invasion, and the expression of EMT genes. Knockdown of IL-17RA inhibited tumor growth and vascularity and decreased the population of Tregs and MDSCs in mouse tumors. Overall, IL-17RA expression was identified to be independently associated with the prognosis of patients with CRC.
    Preclinical • Journal
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    IL17A (Interleukin 17A) • IL17RA (Interleukin 17 Receptor A) • ITK (IL2 Inducible T Cell Kinase)
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    IL17RA underexpression