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    BIOMARKER:

    IL17A elevation

    i
    Other names: IL17A, CTLA8, IL-17, IL-17A, IL17, Interleukin 17A
    Entrez ID:
    3605
    Related biomarkers:
    Mutation
    1year
    IL-17A Mediates Depressive-Like Symptoms by Inducing Microglia Activation in Psoriasiform Dermatitis Mice. (PubMed, Immun Inflamm Dis)
    In the pathological condition of psoriasis, systemic IL-17A elevation can trigger microglia activation, provoke pro-inflammation mediators to release, evoke neuroinflammation, subsequently inhibit hippocampal neurogenesis, and result in depression. IL-17A, as an important pathogenic factor in psoriasis, contributes to its critical role in mediating systemic inflammation and depression comorbidity.
    Preclinical • Journal
    |
    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL10 (Interleukin 10) • IL17A (Interleukin 17A) • IL1B (Interleukin 1, beta) • IL4 (Interleukin 4)
    |
    IL1A elevation • IL17A elevation • IL6 expression
    |
    Zyclara (imiquimod)
    over2years
    Abnormal generation of IL-17A represses tumor infiltration of stem-like exhausted CD8 T cells to demote the antitumor immunity. (PubMed, BMC Med)
    Abnormal generation of IL-17A mainly repressed tumor infiltration of stem-like exhausted CTLs. ICB-based immunotherapeutic efficacy could be upgraded with administration of anti-IL-17A, when treatment-related IL-17A elevation occurred due to tissue damage, such as acute colitis.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    CD8 (cluster of differentiation 8) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • ICAM1 (Intercellular adhesion molecule 1) • IL17A (Interleukin 17A) • SLAMF6 (SLAM Family Member 6)
    |
    IL1A elevation • SLAMF6 expression • IL17A elevation