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    BIOMARKER:

    IL17A elevation

    i
    Other names: IL17A, CTLA8, IL-17, IL-17A, IL17, Interleukin 17A
    Entrez ID:
    3605
    Related biomarkers:
    Mutation
    1year
    Abnormal generation of IL-17A represses tumor infiltration of stem-like exhausted CD8 T cells to demote the antitumor immunity. (PubMed, BMC Med)
    Abnormal generation of IL-17A mainly repressed tumor infiltration of stem-like exhausted CTLs. ICB-based immunotherapeutic efficacy could be upgraded with administration of anti-IL-17A, when treatment-related IL-17A elevation occurred due to tissue damage, such as acute colitis.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    CD8 (cluster of differentiation 8) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • ICAM1 (Intercellular adhesion molecule 1) • IL17A (Interleukin 17A) • SLAMF6 (SLAM Family Member 6)
    |
    IL1A elevation • SLAMF6 expression • IL17A elevation