IL13 (Interleukin 13)

P=N/A, N=52, Recruiting, Fondazione del Piemonte per l'Oncologia

P=N/A, N=110, Recruiting, Fondazione del Piemonte per l'Oncologia

PBPs suppress HCC progression in association with modulation of TAM polarization and inhibition of JAK2/STAT3 signaling. These findings provide mechanistic insight into the immunomodulatory actions of PBPs and support their further investigation as macrophage-targeting agents for HCC.

In the hippocampus, H2 upregulated nuclear factor erythroid 2-related factor 2 (NRF2), attenuated nuclear factor kappa B (NF-κB) activation, reduced the BAX/BCL-2 ratio, preserved neuronal nuclei (NEUN) expression, and decreased hippocampal Aβ42 burden. Collectively, these findings indicate that H2 inhalation confers multi-faceted neuroprotection in 5xFAD mice by restoring redox homeostasis, suppressing inflammation, improving mitochondrial function, and limiting Aβ accumulation.

Pediatric sepsis is characterized by dysregulation of multiple immune and inflammatory pathways rather than isolated protein abnormalities. IL-10 and related cytokine signaling emerged as central nodes, providing insights into the balance between hyperinflammation and immunosuppression in critically ill children. Associations between pathways and clinical variables suggest that specific pathogen types and infection sources trigger distinct patterns of biological network activation, offering potential targets for patient stratification and pathway-directed therapeutics.

In conclusion, ABCB1 expression in macrophages differs by the cell model (THP-1 cell line vs. primary PBMC) and the polarization phenotype (M1 vs. M2). Strong rifampicin-mediated enhancements of ABCB1 were only observed in THP-1-derived M1 and M2 cells.

Our study highlights key molecular and immune differences across R/M SCCHN subgroups, identifies potential biomarkers, and suggests biological rationales for tailored therapeutic strategies.

P=N/A, N=280, Not yet recruiting, Medical University of Gdansk

Although causality cannot be established, inhibition of type 2 immune pathways may be associated with atypical inflammatory manifestations of latent helminth infections. Clinicians should remain vigilant for inflammatory presentations when prescribing biologic agents, particularly in endemic regions.

In this South African cohort, HIV exposure-specific associations were observed between certain mother and child immune markers and child neurometabolite ratios at 2-3 years. Larger, longitudinal neuroimaging studies integrating neurodevelopmental outcomes are needed to clarify mechanisms and clinical implications.

miR-206-3p participates in heat stroke-induced central nervous system injury through targeting HSP90αA1, which inhibits promotes apoptosis, and impairs mitochondrial function.

P2, N=403, Recruiting, Innovent Biologics (Suzhou) Co. Ltd. | Not yet recruiting --> Recruiting