IL13 (Interleukin 13)

Collectively, the interference of DPPE-PEG with iNKT cells activation evidenced by reduced CD1d expression and IL-13 cytokine, with subsequently retarded activation of JAK1/STAT6 inflammatory signaling and preserved intestinal mucosa could, at least partly, contribute to impeding the progression of colitis. These findings reinforce our suggestion that DPPE-PEG could be an effective and promising candidate for retarding the advancement of ulcerative colitis.

Both A. indicum L. extract (HAEAI) and its phytomolecules effectively inhibited ionomycin-induced allergic responses, as evidenced by reduced β-hexosaminidase and histamine release, decreased pro-inflammatory cytokines (IL-4, TNF-α), and increased anti-inflammatory cytokines (IL-6 and IL-13). SYD, MC, and M3IC were shown to alleviate ionomycin-induced allergic symptoms, emerging as potential drug candidates for the management of allergic conditions.

A short bout of exercise modifies the inflammatory cytokine profile in all participants, with the most significant changes observed in the O-A group. Future studies on exercise training should include inflammatory cytokine measurements to validate these findings and further explore the unique inflammatory responses in obese asthmatic patients.

This study provides evidence that immobilizing HDL onto biomaterial surfaces can simultaneously regulate immune responses and stimulate bone regeneration. Such multifunctional coatings offer a promising strategy to enhance osseointegration and long-term implant success, especially in high-risk patient groups such as individuals with diabetes or cancer.

These findings uncover a feed-forward loop in which the RPS4Y1-EIF1AY-CD134 axis suppresses IL-4/IL-13-DDR1 signaling, thereby suppressing M2 macrophage polarization and recruitment, and sustaining tumor growth through reciprocal crosstalk between tumor cells and macrophages. Collectively, our study elucidates a novel immune regulatory pathway driving sex differences in MM and highlights EIF1AY as a promising target for precision immunotherapy in male patients.

The neoantigen LLC1-M02 from the murine LLC1 cell line exhibits strong immunogenicity. The LLC1-M02-DC vaccine combined with CpG enhances the inhibitory effect on lung "cold" tumors.

P=N/A, N=40, Completed, Federico II University | Recruiting --> Completed

Host gene variants involved in trafficking (FYCO1 and RAB7A) and immune signaling (FOXA2, SFTPD, STAT3, and TET2) were associated with differential infection profiles. These findings show that SARS-CoV-2 induces variant- and tumor-specific morphological and immunological changes in cancer PDOs, highlighting the potential of this model to unravel host-virus interactions and identify genetic factors that shape infection outcomes in cancer.

The clinical use and indication expansion of the anti-IL-4Rα antibody dupilumab has made IL-4 signaling an attractive target for therapeutic modulation...Furthermore, Nico-52 and a lead analog were investigated for their tumor suppressive effects in syngeneic murine tumor models, where small-molecule IL-4 inhibition yielded significant tumor inhibition, shifted macrophage polarization, and our optimized lead analog improved animal survival. These studies show the promise of small-molecule cytokine inhibitors for IL-4 mediated processes of disease.

There were no other significant correlations between circulating cytokine levels and post-injury outcomes following correction for multiple comparisons. These findings provide initial, hypothesis-generating evidence that higher levels of circulating inflammatory cytokines at the time of a second mild traumatic brain injury may be associated with decreased susceptibility to a second mild traumatic brain injury, highlighting the complex role of inflammation in repeated mild traumatic brain injury.

ILC1 from NV-HCC also displayed enhanced IL-2/IL-15 signaling and interactions with CD8 + T cells via HLA-E, suggestive of potential antitumor crosstalk. While our single-cell cohort size was limited, necessitating validation in larger datasets, our study reveals etiology-associated differences in ILC phenotypes in HCC and provides insight into their potential roles in modulating immune responses within the tumor microenvironment.

P2/3, N=24, Terminated, University of Zurich | Not yet recruiting --> Terminated | Trial primary completion date: Dec 2024 --> Mar 2025; treatment group completed but insufficient recruitment control group