IL10 underexpression

This study shows that milk SC maintains lower proviral load levels than PBMC. This first report on Th1 and Th2 cytokines expression levels in SC may be relevant to future control strategies for BLV infection, mastitis, and udder health management.

Low IL10 expression or loss of IL-10R-STAT3 signaling correlated with increased frequencies of exhausted CD8 T cells and poor survival in CLL and in breast cancer patients. Thus, balance between PD-1, exhausted CD8 T cells and functional PD-1 TCF-1 CD8 T cells is regulated by cell-intrinsic IL-10R signaling, with implications for immunotherapy.

All the enrolled patients received an oxaliplatin-containing or irinotecan-containing regimen. In addition, the low IL-10 expression level in tumor tissue was significantly associated with the improved OS for the irinotecan-containing regimen (p = 0.023). Our study demonstrated that IL-10 could act as a prognostic biomarker for mCRC patients undergoing irinotecan-containing chemotherapy.

All the enrolled patients received oxaliplatin-containing or irinotecan-containing regimen. Funding: Has not received any funding. Clinical trial identification: NCT03532711 (retrospectively registered: May 20th, 2018).