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    DRUG CLASS:

    IL-2R agonist

    Related drugs:
    18d
    L19IL2/TNF in Patients With Basal Cell Carcinoma (clinicaltrials.gov)
    P2, N=92, Recruiting, Philogen S.p.A. | Not yet recruiting --> Recruiting
    Enrollment open • Trial initiation date
    |
    Nidlegy (darleukin/fibromun)
    25d
    An open-label, dose-escalation and dose-expansion clinical study to evaluate the safety, tolerability, pharmacokinetics and efficacy of combination therapy with LAT010 plus pembrolizumab in patients with locally advanced or metastatic solid tumors (ChiCTR2600121542)
    P=N/A, N=27, Shanxi Bethune Hospital; Shanxi Bethune Hospital
    New trial
    |
    EGFR (Epidermal growth factor receptor) • PD-L1 (Programmed death ligand 1) • ALK (Anaplastic lymphoma kinase) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS)
    |
    EGFR mutation • ALK mutation
    |
    Keytruda (pembrolizumab)
    2ms
    Rezpegaldesleukin (NKTR-358) in New Onset Type 1 Diabetes Mellitus (clinicaltrials.gov)
    P2, N=66, Recruiting, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Not yet recruiting --> Recruiting | Trial completion date: May 2029 --> May 2028 | Initiation date: Nov 2025 --> Mar 2026
    Enrollment open • Trial completion date • Trial initiation date
    2ms
    A Phase II Study of ILKN421H With Pembrolizumab in Advanced Non-Small Cell Lung Cancer (clinicaltrials.gov)
    P2, N=80, Not yet recruiting, iLeukon Therapeutics, Inc.
    New P2 trial
    |
    PD-L1 (Programmed death ligand 1)
    |
    PD-L1 expression
    |
    Keytruda (pembrolizumab)
    3ms
    PH-ICKPD1-02/21: A phase 2 study of the efficacy of intratumorally administered L19IL2 or L19TNF or L19IL2/L19TNF, all in combination with systemic anti-PD1 Pembrolizumab, in stage III/IV unresectable melanoma patients with resistance to anti-PD1 checkpoint inhibitors (INTACT / MeRCI) (2024-519326-20-00)
    P1/2, N=65, Not yet recruiting, Philogen S.p.A.
    New P1/2 trial • Checkpoint inhibition
    |
    BRAF (B-raf proto-oncogene)
    |
    BRAF mutation
    |
    Keytruda (pembrolizumab) • Nidlegy (darleukin/fibromun) • darleukin (L19IL2)
    3ms
    PHL19IL2TNFCOMB04/24: L19IL2 or L19TNF or L19IL2/TNF in patients with basal cell carcinoma (BCC) (2025-523229-16-00)
    P1/2, N=85, Not yet recruiting, Philogen S.p.A.
    New P1/2 trial
    |
    Nidlegy (darleukin/fibromun) • darleukin (L19IL2)
    3ms
    L19IL2/L19TNF in patients with cutaneous squamous cell carcinoma (2025-523231-19-00)
    P1/2, N=54, Not yet recruiting, Philogen S.p.A.
    New P1/2 trial
    |
    Nidlegy (darleukin/fibromun) • darleukin (L19IL2)
    3ms
    L19IL2/TNF in patients with basal cell carcinoma (2025-523230-77-00)
    P1/2, N=53, Not yet recruiting, Philogen S.p.A.
    New P1/2 trial
    |
    Nidlegy (darleukin/fibromun) • darleukin (L19IL2)
    5ms
    Neo-DREAM: Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C/D Melanoma Patients (clinicaltrials.gov)
    P3, N=186, Recruiting, Philogen S.p.A. | Trial completion date: Jun 2026 --> Dec 2031 | Trial primary completion date: Jun 2024 --> Dec 2027
    Trial completion date • Trial primary completion date
    |
    Nidlegy (darleukin/fibromun)
    5ms
    A Study to Evaluate Safety and Anti-Tumor Activity of Eciskafusp Alfa (RO7284755) Alone or in Combination With Atezolizumab in Participants With Advanced and/or Metastatic Solid Tumors (clinicaltrials.gov)
    P1, N=189, Completed, Hoffmann-La Roche | Active, not recruiting --> Completed | Trial completion date: Aug 2026 --> Oct 2025 | Trial primary completion date: Jan 2026 --> Oct 2025
    Trial completion • Trial completion date • Trial primary completion date • Tumor mutational burden • IO biomarker
    |
    PD-L1 (Programmed death ligand 1)
    |
    Tecentriq (atezolizumab) • eciskafusp alfa (RG6279)
    6ms
    L19IL2/L19TNF in Patients With Cutaneous Squamous Cell Carcinoma (clinicaltrials.gov)
    P2, N=92, Not yet recruiting, Philogen S.p.A.
    New P2 trial
    |
    Nidlegy (darleukin/fibromun) • darleukin (L19IL2)
    6ms
    L19IL2/TNF in Patients With Basal Cell Carcinoma (clinicaltrials.gov)
    P2, N=92, Not yet recruiting, Philogen S.p.A.
    New P2 trial
    |
    Nidlegy (darleukin/fibromun) • darleukin (L19IL2)