^
    1d
    Phase1 Basket Trial Of CAR.70-Engineered IL15-Transduced With TGFBR2 Knock Out Cord Blood-Derived NK Cells For Relapsed/Refractory Lymphoid Malignancies (clinicaltrials.gov)
    P1, N=60, Recruiting, M.D. Anderson Cancer Center | Not yet recruiting --> Recruiting | Initiation date: Aug 2026 --> May 2026
    Enrollment open • Trial initiation date • Pan tumor
    |
    ABL1 (ABL proto-oncogene 1) • BCR (BCR Activator Of RhoGEF And GTPase)
    |
    cyclophosphamide • fludarabine IV
    5d
    AAAV0505: A Study of NKX019, a CD19 CAR NK Cell Therapy, in Subjects With Systemic Lupus Erythematosus (clinicaltrials.gov)
    P1, N=6, Enrolling by invitation, Hospital for Special Surgery, New York | Suspended --> Enrolling by invitation
    Enrollment open
    |
    cyclophosphamide • NKX019
    17d
    Phase 1/2 Study TROP2 CAREngineered Cord Blood-Derived NK Cells + Belzutifan In Pancreatic Cancer (clinicaltrials.gov)
    P1/2, N=37, Recruiting, M.D. Anderson Cancer Center | Not yet recruiting --> Recruiting
    Enrollment open
    |
    Welireg (belzutifan)
    1m
    A Phase 1/2 Study of NKX019 in Subjects With Immune-Mediated Diseases (Ntrust-2) (clinicaltrials.gov)
    P1/2, N=240, Recruiting, Nkarta, Inc. | N=144 --> 240
    Enrollment change
    |
    cyclophosphamide • fludarabine IV • NKX019
    2ms
    Agni-01: Safety and Efficacy of OBX-115 in Advanced Solid Tumors (clinicaltrials.gov)
    P1/2, N=208, Recruiting, Obsidian Therapeutics, Inc. | Trial completion date: Jun 2028 --> Jun 2029 | Trial primary completion date: Jun 2028 --> Jun 2029
    Trial completion date • Trial primary completion date
    |
    PD-L1 (Programmed death ligand 1) • BRAF (B-raf proto-oncogene)
    |
    BRAF mutation
    |
    cyclophosphamide • fludarabine IV • OBX-115
    2ms
    GTB-5550 in Advanced Solid Tumors (clinicaltrials.gov)
    P1, N=175, Recruiting, Masonic Cancer Center, University of Minnesota
    New P1 trial • First-in-human
    |
    GTB-5550
    2ms
    AAAV0505: A Study of NKX019, a CD19 CAR NK Cell Therapy, in Subjects With Systemic Lupus Erythematosus (clinicaltrials.gov)
    P1, N=6, Suspended, Columbia University | Recruiting --> Suspended
    Trial suspension
    |
    cyclophosphamide • NKX019
    3ms
    A Clinical Study to Evaluate the Efficacy and Safety of VG2025 in Intrahepatic Cholangiocarcinoma (clinicaltrials.gov)
    P2, N=30, Not yet recruiting, Virogin Biotech Ltd.
    New P2 trial
    |
    VG201
    3ms
    GPC3 CAR T Cells With IL-15 and IL-21 for Recurrent ATRT and CNS Rhabdoid Tumors (RADIANT) (clinicaltrials.gov)
    P1, N=21, Not yet recruiting, Baylor College of Medicine
    New P1 trial
    |
    GPC3 (Glypican 3)
    |
    GPC3-CAR and IL15 plus IL21
    3ms
    Phase 1/2 Window Of Opportunity Study Of TROP2 CAR/IL-15 TGFBR2 KO NK Cells Delivered Intraperitoneally For The Management Of Gastric Cancer Metastatic To The Peritoneum (clinicaltrials.gov)
    P1/2, N=10, Not yet recruiting, M.D. Anderson Cancer Center
    New P1/2 trial
    |
    cyclophosphamide • fludarabine IV • rimiducid (AP1903)
    3ms
    Agni-01: Safety and Efficacy of OBX-115 in Advanced Solid Tumors (clinicaltrials.gov)
    P1/2, N=208, Recruiting, Obsidian Therapeutics, Inc. | N=52 --> 208
    Enrollment change
    |
    PD-L1 (Programmed death ligand 1) • BRAF (B-raf proto-oncogene)
    |
    BRAF mutation
    |
    cyclophosphamide • fludarabine IV • OBX-115
    3ms
    A Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Biologic Effect of VG2062 in Patients With Solid Tumors (clinicaltrials.gov)
    P1, N=30, Recruiting, Shanghai Virogin Biotech Co., Ltd. | Not yet recruiting --> Recruiting
    Enrollment open