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    GENE:

    IGLL1 (Immunoglobulin Lambda Like Polypeptide 1)

    i
    Other names: IGLL1, Immunoglobulin Lambda Like Polypeptide 1, Immunoglobulin Lambda-Like Polypeptide 1, IGVPB, IGL5B, Immunoglobulin-Related Protein 14.1, CD179 Antigen-Like Family Member B, CD179b Antigen, Ig Lambda-5, CD179B, IGL1, IGLL, Immunoglobulin Omega Polypeptide Chain, Pre-B Lymphocyte-Specific Protein-2, Immunoglobulin-Related 14.1 Protein, Immunoglobulin Omega Polypeptide, Lambda 5, IGLJ14.1, Lambda5, CD179b, VPREB2, AGM2, IGO
    Associations

    News

    Trials
    2ms
    H195Y mutation of IKZF3 identified in a mouse model of precursor B cell acute lymphoblastic leukemia impairs transcriptional repression activity and increases protein stability. (PubMed, J Leukoc Biol)
    Second, this mutation increases protein stability, resulting in higher levels of protein expression. This study provides insight into mechanisms by which IKZF3 mutations promote immunodeficiency, leukemia, and lymphoma.
    Preclinical • Journal
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    IKZF3 (IKAROS Family Zinc Finger 3) • IL7R (Interleukin 7 Receptor) • IL7 (Interleukin 7) • IGLL1 (Immunoglobulin Lambda Like Polypeptide 1)
    6ms
    Prognostic Value and Immune Characterization of Genes Associated with Childhood Acute Leukemia applying Single-Cell RNA Sequencing. (PubMed, Endocr Metab Immune Disord Drug Targets)
    This study revealed the critical role of B cells in cALL, and the prognostic model showed a high prediction accuracy, providing a potential target for individualized treatment of cALL.
    Journal
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    PSMA2 (Proteasome 20S Subunit Alpha 2) • CENPF (Centromere Protein F) • IGLL1 (Immunoglobulin Lambda Like Polypeptide 1)
    almost2years
    Comparative analysis of dynamic transcriptomes reveals specific COVID-19 features and pathogenesis of immunocompromised populations. (PubMed, mSystems)
    Our observed differential genes/complexes and clinical indicators of normal/long infection and deceased COVID-19 patients provide clues for understanding the mechanism of COVID-19 progression in hematological tumors. Finally, our study provides an important data resource that supports the increasing value of the application of publicly accessible data sets to public health.
    Journal
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    SERPINE1 (Serpin Family E Member 1) • APOE (Apolipoprotein E) • VPREB1 (V-Set Pre-B Cell Surrogate Light Chain 1) • IGLL1 (Immunoglobulin Lambda Like Polypeptide 1)
    almost2years
    HERVK-mediated regulation of neighboring genes: implications for breast cancer prognosis. (PubMed, Retrovirology)
    This study represents the first report on the regulatory potential of HERV-K in the neighboring breast cancer genome. We identified three key HERV-Ks and five neighboring genes that hold promise as novel targets for future interventions and treatments for breast cancer.
    Journal • Tumor mutational burden • IO biomarker
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    TMB (Tumor Mutational Burden) • CD48 (CD48 Molecule) • LRRC8A (Leucine Rich Repeat Containing 8 VRAC Subunit A) • SLAMF7 (SLAM Family Member 7) • IGLL1 (Immunoglobulin Lambda Like Polypeptide 1)
    over2years
    Atypical Stem Cell, Pre-B-Cell, T-Cell and Myeloid Gene Expression Characterizes Early Waldenstrom's Macroglobulinemia Clones Which Diminishes with Advancing Disease and Has Therapeutic Implications (ASH 2023)
    This analysis suggests that stem cell program reactivation and atypical marker expression characterize early WM clones that are ultimately replaced by clones exhibiting more typical B-cell markers with disease progression. The findings may be relevant to treatment selection and provide a framework for investigating subtype and early/late evolutionary staging in the treatment approach to WM.
    IO biomarker
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    KIT (KIT proto-oncogene, receptor tyrosine kinase) • MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • CD8 (cluster of differentiation 8) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • CD33 (CD33 Molecule) • CD34 (CD34 molecule) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • CD14 (CD14 Molecule) • CD27 (CD27 Molecule) • FCGR3A (Fc Fragment Of IgG Receptor IIIa) • PRDM1 (PR/SET Domain 1) • VPREB1 (V-Set Pre-B Cell Surrogate Light Chain 1) • XBP1 (X-box-binding protein 1) • CEACAM8 (CEA Cell Adhesion Molecule 8) • CXCL1 (Chemokine (C-X-C motif) ligand 1) • RAG1 (Recombination Activating 1) • IGLL1 (Immunoglobulin Lambda Like Polypeptide 1)
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    MYD88 mutation • CD19 expression • CD33 expression
    over2years
    Early Subclones Showing Aberrant Co-Expression of Stem Cell, T Cell and Myeloid Genes Can be Detected By Flow Cytometry in MYD88 Mutated Waldenström's Macroglobulinemia Patients (ASH 2023)
    In WM primary cells, we observed the existence of a clonal B cell population that appears to re-activate stem cell programming early on and progressively is replaced by clones bearing more typical B cell markers with disease expansion. This study lays the foundation to develop a widely accessible methodology to accurately diagnose IgM MGUS/early-stage WM and monitor disease evolution. Flow-based sorting of these subclones will allow targeted multi-omic studies with insights into disease pathogenesis and targeted therapeutic applications.
    Clinical
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    KIT (KIT proto-oncogene, receptor tyrosine kinase) • MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • CD8 (cluster of differentiation 8) • CD33 (CD33 Molecule) • CD34 (CD34 molecule) • SDC1 (Syndecan 1) • FCGR3A (Fc Fragment Of IgG Receptor IIIa) • PRDM1 (PR/SET Domain 1) • VPREB1 (V-Set Pre-B Cell Surrogate Light Chain 1) • XBP1 (X-box-binding protein 1) • CEACAM8 (CEA Cell Adhesion Molecule 8) • IGLL1 (Immunoglobulin Lambda Like Polypeptide 1)
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    MYD88 mutation • KIT expression
    over2years
    Super Enhancer Regulatory Gene FYB1 Promotes the Progression of T Cell Acute Lymphoblastic Leukemia by Activating IGLL1. (PubMed, J Immunol Res)
    As a downstream target of FYB1, IGLL1 exerted similar role as FYB1 in inhibiting growth of T-ALL cells. Our results suggested that FYB1 gene played important role in regulating self-renewal of T-ALL cells by activating IGLL1, representing a promising therapeutic target for T-ALL patients.
    Journal
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    IGLL1 (Immunoglobulin Lambda Like Polypeptide 1)
    over2years
    Expression of IGLL1 Gene and Its Clinical Significance in Pediatric T-ALL (PubMed, Zhongguo Shi Yan Xue Ye Xue Za Zhi)
    In pediatric T-ALL, the OS rate of children with high expression of IGLL1 gene was significantly higher than that of children with low expression of IGLL1 gene, and the expression level of IGLL1 gene was an independent factor affecting the survival of children with T-ALL, which suggests that IGLL1 is a marker of good clinical prognosis of children with T-ALL.
    Journal
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    IGLL1 (Immunoglobulin Lambda Like Polypeptide 1)
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    prednisone