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    BIOMARKER:

    IGKC overexpression

    i
    Other names: IGKC, Immunoglobulin Kappa Constant, HCAK1, Immunoglobulin Kappa (Invariant Region), Immunoglobulin Kappa Light Chain (VJ), Immunoglobulin Kappa Constant Region, Ig Kappa Chain C Region CUM, Ig Kappa Chain C Region ROY, Ig Kappa Chain C Region AG, Ig Kappa Chain C Region EU, Ig Kappa Chain C Region OU, Ig Kappa Chain C Region TI, Ig Kappa Chain C Region, IGKCD, Km
    Entrez ID:
    3514
    over2years
    Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis. (PubMed, Front Med)
    Their expression was positively correlated with those of immune checkpoint genes (e.g., LGALS33) and poor survivals as validated by the increased expression of LGALS3 upon IGKC overexpression in Jurkat cells. This finding indicated a potential inhibitory role in tumor-infiltrating lymphocytes and could provide a new way of cancer immune evasion.
    Journal
    |
    EGFR (Epidermal growth factor receptor) • TP53 (Tumor protein P53) • LGALS3 (Galectin 3) • IGKC (Immunoglobulin Kappa Constant) • PTPRZ1 (Protein Tyrosine Phosphatase Receptor Type Z1)
    |
    TP53 mutation • EGFR mutation • IDH wild-type • IGKC overexpression
    3years
    Single-cell transcriptome analysis reveals functional changes in tumour-infiltrating B lymphocytes after chemotherapy in oesophageal squamous cell carcinoma. (PubMed, Clin Transl Med)
    Our findings provide novel insights for the heterogeneity of TIL-Bs during chemotherapy and will be useful to understand the clinical importance of TIL-Bs.
    Journal • IO biomarker
    |
    CD40 (CD40 Molecule) • IGKC (Immunoglobulin Kappa Constant)
    |
    IGKC overexpression
    over3years
    High IGKC-Expressing Intratumoral Plasma Cells Predict Response to Immune Checkpoint Blockade. (PubMed, Int J Mol Sci)
    In this study, we have dissected the basal TME composition at the gene expression and cellular levels that predict response to Nivolumab and prognosis...Finally, we generated a 15-gene prediction model that outperformed the current reference score in eight ICB-treated metastatic melanoma cohorts. The evidenced major contribution of basal intratumoral IGKC and Plasma cells in good response and outcome in ICB in metastatic melanoma is a groundbreaking finding in the field beyond the role of T lymphocytes.
    Journal • Checkpoint inhibition • PD(L)-1 Biomarker
    |
    SDC1 (Syndecan 1) • IGKC (Immunoglobulin Kappa Constant)
    |
    IGKC overexpression
    |
    Opdivo (nivolumab)