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    GENE:

    IGK (Immunoglobulin Kappa Locus)

    i
    Other names: IGK, Immunoglobulin Kappa Locus, IGK@
    Associations

    News

    Trials
    2ms
    Assessment of Bone Marrow Involvement in B-Cell non-Hodgkin Lymphoma Using Immunoglobulin Gene Rearrangement Analysis with Next-Generation Sequencing. (PubMed, J Clin Lab Anal)
    NGS-based clonality analysis is an analytic platform with a substantial overall agreement with histopathological analysis. Assessment of both IGH and IGK genes for the clonal rearrangement analysis could be considered for the optimal diagnostic performance of BMI detection in B-cell NHL.
    Journal • Next-generation sequencing
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    IGK (Immunoglobulin Kappa Locus)
    2ms
    A Rare Case of Non-IgM Lymphoplasmacytic Lymphoma with Unusual Lack of Immunoglobulin Light Chain Production. (PubMed, Am J Case Rep)
    The patient received 6 cycles of rituximab and bendamustine treatment, and no residual marrow involvement was found on the follow-up bone marrow biopsy. CONCLUSIONS We report a non-IgM LPL case featuring no light chain production and no heavy chain secretion, which we believe is the first reported case of this kind in the literature.
    Journal
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    MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • IGK (Immunoglobulin Kappa Locus)
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    MYD88 L265P • CXCR4 mutation
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    Rituxan (rituximab) • bendamustine
    1year
    IMMUNOGLOBULIN GENE REARRANGEMENT IN KOREAN PATIENTS WITH B-LYMPHOBLASTIC LEUKEMIA – AN IMMUNOPHENOTYPE AND REPERTOIRE ANALYSIS (EHA 2023)
    Clonal IGH and/or IGK rearrangements were observed in 95.7% of pediatric patients and 87.0% of adult patients; however, only 82.9% of pediatric patients had clonal rearrangements, which is suitable for MRD monitoring. Absence or low clonal IGH/IGK read was observed in 60% of pro-B-ALL in pediatric patients. TRB and TRG testswere helpful for finding clonal sequences.
    Clinical
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    IGH (Immunoglobulin Heavy Locus) • IGK (Immunoglobulin Kappa Locus)
    over1year
    T Cell Epitope Prediction within the Clonotypic Immunoglobulin Heavy and Light Chains in Patients with Multiple Myeloma (ASH 2022)
    Many of the identified peptides derive from SHM, implying that the SHM which shapes the MM BcR IG repertoire may produce immunogenic CD4+/CD8+ T cell epitopes. Their actual immunogenicity has to be tested in ex vivo studies, currently underway by our group.
    Clinical • IO biomarker
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    CD8 (cluster of differentiation 8) • IGH (Immunoglobulin Heavy Locus) • HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1) • CD4 (CD4 Molecule) • SDC1 (Syndecan 1) • HLA-B (Major Histocompatibility Complex, Class I, B) • IGKC (Immunoglobulin Kappa Constant) • HLA-C (Major Histocompatibility Complex, Class I, C) • IGK (Immunoglobulin Kappa Locus)