IGH (Immunoglobulin Heavy Locus)

Unmutated IGHV status predicted inferior outcomes in the overall CLL cohort, but not among patients with AIHA. Our findings underscore the importance of routine AIHA screening in high-risk CLL and support consideration of targeted therapies to mitigate the adverse impact of AIHA on long-term survival.

This downregulation on microglia was accompanied by enhanced uptake of cells expressing MOG, suggesting Fc receptor-mediated internalization of MOG immune complexes. Introduction of anti-MOG IgG in EAE recapitulates key aspects of pediatric MOGAD and enables dissection of the mechanisms underlying anti-MOG antibody-mediated immunopathogenesis.

To the best of our knowledge, this case represents the longest reported interval between primary leukemia and secondary HS, highlighting the potential for lineage switching and transformation over extended periods. These findings underscore the need for ongoing research on the mechanisms underlying "transdifferentiation", including the roles of transcription factors, cytokine signaling, and epigenetic modifications.

P2, N=24, Recruiting, The First Affiliated Hospital with Nanjing Medical University

Integration of cytogenetic data revealed a strong enrichment of del(17p), del(11q), and trisomy 12 within U-CLL, whereas M-CLL was characterized by higher frequency of isolated del(13q). In summary, this study highlights distinct IGHV-IGHD-IGHJ pairing preferences and the heterogenous distribution of stereotyped subsets, revealing biologically meaningful associations with TP53 mutation and cytogenetic profiles.

Later on, confirmation with histopathology and IHC, the patient underwent complete excision with hemi-mandibulectomy followed by adjuvant radiation therapy. This case emphasises the diagnostic and therapeutic approach for ASPS in the buccal mucosa of a young child.

This case of WM with renal AHL amyloidosis highlights the importance of keeping renal amyloidosis in mind in patients with proteinuria. The favourable hematologic and renal response to treatment with bendamustine and rituximab in this case adds valuable data for the management of WM complicated by renal amyloidosis.

P2/3, N=456, Not yet recruiting, Hemato-Oncologie voor Volwassenen Nederland (Hovon) Stichting

Time-limited BR-VR achieved high uMRD rates and durable remissions with a manageable safety profile. While the treatment landscape in CLL has largely shifted toward chemotherapy-free regimens, these data demonstrate the biological proof-of-concept that limited induction chemotherapy can effectively mitigate TLS risk and facilitate safe outpatient ramp-up of venetoclax.

CLL in Türkiye demonstrates region-specific immunogenetic features while preserving established clinico-biological correlations. Integration of IGHV status, cytogenetics, and BCR stereotypy may improve risk stratification in underrepresented populations.

P3, N=420, Recruiting, AstraZeneca | Not yet recruiting --> Recruiting | Trial completion date: Aug 2033 --> Apr 2032 | Trial primary completion date: Nov 2032 --> Aug 2031

Notably, the rate of clonal IGH gene rearrangements was significantly different between heavy-chain and light-chain only MM groups. This is the first study in Vietnamese MM patients to comprehensively describe the characteristics of IG gene rearrangements.