IGFBP7 (Insulin Like Growth Factor Binding Protein 7)

CSF IGFBP7 was found to be closely associated with CSF TNF-α, showing potential diagnostic utility in MS. A dual-marker model combining CSF IGFBP7 and TNF-α improved diagnostic performance, suggesting that IGFBP7 reflects inflammatory processes relevant to MS.

A panel of protein biomarkers, some new (IGFBP7, HGF) and some previously known in PLWH (CLEC6A), could help identify PLWH at higher risk of developing CVD. If confirmed, these scores could be used with CVD and HIV-related factors to identify PLWH at risk for CVD who would benefit from proactive risk reduction strategies.

Moreover, we identified the GALNT10 inhibitor Luteolin, which effectively suppresses ovarian cancer metastasis, modulates the immunosuppressive tumor microenvironment through tumor vascular-immune crosstalk, and exhibits synergistic effects with anti-PD1 therapy. Collectively, our findings indicate that GALNT10 facilitates ovarian cancer metastasis through the induction of tumor cell EMT and tumor vascular dysfunction, suggesting that GALNT10 inhibitors represent a promising avenue for the development of novel therapeutic strategies in ovarian cancer.

This study establishes iCAFs and γδT cell loss as central drivers of cSCC aggressiveness and nominates CXCL8/TGFβ/IGFBP7 dysregulation as a biomarker framework for risk stratification. Collectively, these findings unveil actionable therapeutic targets and provide a molecular basis for personalizing management strategies, particularly for identifying and treating very highrisk cSCC patients who may benefit from intensified surgical approaches, adjuvant therapies, or novel targeted interventions.

More importantly, CBP-D8 peptide combined with radiotherapy significantly abrogated tumor growth and elicited systemic antitumor immune response. Our study identified a novel peptide blocking CD93/IGFBP7 interaction to normalize tumor vascular function, as well as revealed an approach to promote a favorable tumor microenvironment for the therapeutic intervention.

At markedly reduced intravenous doses, IGFBP7-sEVs efficiently concentrated temozolomide (TMZ) within glioma and elicited pronounced tumor growth inhibition...Our data suggest that IGFBP7-modified sEVs represent a novel platform that enables highly efficient, glioma VECs-targeted delivery of therapeutics into glioma, and are adaptable to a broad spectrum of agents, especially immunomodulators. It is a novel and effective strategy for treating gliomas.

This study underscores the biological relevance of RNA editing in CRC, highlighting its impact on chemoresistance, the tumor microenvironment, and subtype-specific gene regulation. Our findings suggest that RNA editing represents a critical post-transcriptional regulatory layer in CRC and holds potential as a biomarker and therapeutic target.

This study identifies eight tumor mechanics-related genes as prognostic biomarkers for GC through comprehensive bioinformatic analyses. These findings may provide preliminary insights into prognostic assessment and targeted therapy for GC, although further validation with larger sample sizes is required to substantiate their clinical applicability.

Functional enrichment and protein-protein interaction analyses revealed that CTSC regulates the ECM-integrin-PI3K-Akt signaling pathway, contributing to tumor cell proliferation and survival. The findings establish a multi-omics-based biomarker panel with strong diagnostic utility and mechanistic relevance, suggesting a potential framework for future translational validation in clinical cohorts.

Immunofluorescent double staining was used to examine the co-expression of CD31 in α-SMA-positive CAFs to identify whether the endothelial-to-mesenchymal transition (EndoMT) is involved in the origin, and obvious colocalization was observed. Visium and Visium HD spatial transcriptomics further revealed endothelial cells (ECs) exhibited remarkable co-expression of CAF-specific marker genes and revealed inferred developmental trajectories to CAFs; molecular determinants, including TIMP1, IGFBP7, THBS2, CD74, COL4A1, COL4A2, AEBP1, S100A6, KCTD12, CALD1, IGHG1, SERPINE1, MCL1, MGP, GSTP1, TAGLN, THBS1, and CTGF, were positively correlated with the spatial developmental trajectories of ECs to CAFs; and CTGF exhibited extensive interactions with other common positively correlated molecular determinants and was a highly connected node in the interaction network. ECs that undergo EndoMT may be one of the potential cellular and mechanical origins of CAFs in HCC, and the development of EndoMT may be associated with CTGF.

NAG2 was upregulated in 54/68 patients post-NAC (p<0.00001) and its expression correlated positively with senescence-associated genes. An association between TSPAN4 and TIS post-NAC was identified.