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    BIOMARKER:

    IGFBP6 underexpression

    i
    Other names: IGFBP6, Insulin Like Growth Factor Binding Protein 6, Insulin-Like Growth Factor-Binding Protein 6, IGFBP-6, IBP-6, IBP6, Insulin-Like Growth Factor Binding Protein 6, IGF Binding Protein 6, IGF-Binding Protein 6
    Entrez ID:
    3489
    almost2years
    ELOVL5 and IGFBP6 genes modulate sensitivity of breast cancer cells to ferroptosis. (PubMed, Front Mol Biosci)
    Addition of DHA to commonly used chemotherapeutic drugs enhanced their effect significantly, especially for the cells with low expression of IGFBP6 gene. The results of this study suggest that addition of PUFAs to the treatment regimen for the patients with low expression of IGFBP6 and ELOVL5 genes can be potentially beneficial and is worth testing in a clinically relevant setting.
    Journal
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    GPX4 (Glutathione Peroxidase 4) • IGFBP6 (Insulin Like Growth Factor Binding Protein 6)
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    IGFBP6 underexpression