IGFBP3 (Insulin-like growth factor binding protein 3)

This research revealed the crucial role of CASC15/HNRNPU-IGFBP3 regulatory network in the pathogenesis of LF in BA.

Tumor-specific and host-related biomarkers (IGFBP-3, NLR, and RDW) improved prognostic stratification beyond tumor type. The proposed nomogram demonstrated good discriminatory performance, supporting its potential use in personalized prognostic assessment and treatment planning.

While acromegaly typically manifests with musculoskeletal changes and endocrine abnormalities - including diabetes mellitus, hypertension, and galactorrhea - it also carries a substantial risk of secondary respiratory and cardiac complications. This report highlights the importance of early diagnosis of acromegaly, specifically in identifying, being cognizant of, and preventing respiratory and cardiac complications.

Tear MMP-9, substance P, and IGFBP-3 were significantly altered in DR. Corneal nerve status could be an early indicator and predictor of DR.

The results of this study indicated that QYD ameliorates IBI through multiple targets and signaling pathways, with the p53 signaling pathway playing a key role in its therapeutic effect.

This dual action establishes a feedforward loop that exacerbates metastatic progression. Our findings identify ATP6V1C1 as a dual regulator of LUAD metastasis and suggest a potential stroma-targeted therapeutic approach.

Moreover, IGFBP-3 deletion in tumor cells and small molecule inhibition of TGF-βR1/2 attenuated myotube wasting. Collectively, these results suggest that PDAC derived IGFBP-3 promotes SMW via non-canonical binding of TGF-βRs, warranting formal investigation of IGFBP-3 as a potential therapeutic target for PDAC-related SMW through a novel pathway.

Higher IGF-1 was associated with increased odds for colon cancer, but not rectal cancer, among predominantly non-Hispanic Black individuals with lower socioeconomic status, consistent with findings from predominantly non-Hispanic White cohorts.

Our AI model, using only archival histologic slides, accurately predicted postoperative recurrence in PDAC and revealed image features linked to outcomes and gene expression.

In this American cohort of veterans, P-score significantly predicted PCSM. Adding clinical variables minimally improved accuracy. Accuracy remained high in intermediate-risk patients, wherein there is arguably the greatest need for better risk stratification. Given P-scores can be generated rapidly in-house using a standardized RT-qPCR assay, P-score represents a robust new tool to risk-stratify newly diagnosed patients for PC death, thereby minimizing mismatched treatments.

In addition, recombinant PDZRN4 or screened small molecules retinoic acid showed potent inhibitory effects on EGFR-driven LUAD growth and amelioration of osimertinib resistance...Graphical Abstract: Germline variation rs74955204 (p.G121E, c.362 G > A) in PDZRN4 significantly upregulated PDZRN4 expression and resulted in indolent growth of LUAD. Overexpressed PDZRN4 inhibits the ubiquitylation of HIF-1A by TRIM28, activating HIF-1A-IGFBP3 signaling to promote apoptosis, and inducing NDRG1 to inhibit EGFR-AKT signaling, thus restricting lung cancer cell growth.

Because the C2 subtype involves the MHC-II and PROS signaling pathways, which have been shown to have roles in neuroimmunology, neuroinflammation, and pain regulation, it may serve as a hub for neuro-immune interactions in the tumor microenvironment. Precision treatments for melanoma may be advanced by focusing on the FOSL1 or C2 subtype pathways, which may assist in overcoming immunotherapy resistance.