IGFBP3 (Insulin-like growth factor binding protein 3)

In TH-MYCN mice, which have a high frequency of NB development, Tagln overexpression by induction of the murine Tagln gene significantly reduced tumor formation and prolonged survival. In conclusion, these in vitro and in vivo analyses suggest that TAGLN is a candidate tumor suppressor gene in NB.

Corroborating previous findings, in a secondary analysis, IGF-I levels were associated with the risk of chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) in males with higher body mass index (HR1-SD in obese male = 1.36, 95% CI: 1.14-1.61). Our serological and MR analyses suggest a contributing role of IGF-I in the susceptibility of MM; the CLL/SLL findings warrant further investigation considering sex-specific adiposity.

This model can accurately predict the clinical prognosis of prostate cancer patients after surgery. Moreover, IGFBP3 can be used as a potential therapeutic target for ENZ resistance in prostate cancer.

Chronic low-grade inflammation is a vital pathway linking genetically predicted BMI to breast cancer risk. Genetically predicted BMI is associated with higher genetically predicted CRP levels, potentially through a pathway involving reduced IGF-1 levels, which may attenuate the inverse association between genetically predicted BMI and breast cancer risk.

Epigenetic age in breast tissue, particularly Grim and DNAmTL, is associated with obesity-related metabolic markers, independent of chronological age, BMI, and smoking. Although limited by a moderate sample size, our findings indicate a potential biological pathway linking mAge-related metabolic dysregulation that may provide insight into breast cancer risk.

P2, N=95, Recruiting, Andrea DeCensi | N=70 --> 95

This research revealed the crucial role of CASC15/HNRNPU-IGFBP3 regulatory network in the pathogenesis of LF in BA.

Tumor-specific and host-related biomarkers (IGFBP-3, NLR, and RDW) improved prognostic stratification beyond tumor type. The proposed nomogram demonstrated good discriminatory performance, supporting its potential use in personalized prognostic assessment and treatment planning.

While acromegaly typically manifests with musculoskeletal changes and endocrine abnormalities - including diabetes mellitus, hypertension, and galactorrhea - it also carries a substantial risk of secondary respiratory and cardiac complications. This report highlights the importance of early diagnosis of acromegaly, specifically in identifying, being cognizant of, and preventing respiratory and cardiac complications.

Tear MMP-9, substance P, and IGFBP-3 were significantly altered in DR. Corneal nerve status could be an early indicator and predictor of DR.

The results of this study indicated that QYD ameliorates IBI through multiple targets and signaling pathways, with the p53 signaling pathway playing a key role in its therapeutic effect.

This dual action establishes a feedforward loop that exacerbates metastatic progression. Our findings identify ATP6V1C1 as a dual regulator of LUAD metastasis and suggest a potential stroma-targeted therapeutic approach.