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    BIOMARKER:

    IGF1R expression

    i
    Other names: IGF1R, CD221, IGFIR, IGFR, JTK13, MGC18216, Insulin-like growth factor 1 receptor
    Entrez ID:
    3480
    Related biomarkers:
    Expression
    Mutation
    CNA
    Others
    11ms
    Worse survival of hepatocellular cancer patients with membranous insulin receptor overexpression. (PubMed, Sci Rep)
    Intriguingly, membranous IR expression was associated with worse tumor specific survival (p = 0.017) in the subgroup of patients undergoing sorafenib therapy. IGF1R expression was not associated with survival. In conclusion, our results suggest that membranous IR expression plays a role in HCC prognosis and treatment resistance, inspiring future validation as a potential companion diagnostic in HCC.
    Journal
    |
    IGF1R (Insulin-like growth factor 1 receptor) • IGF1 (Insulin-like growth factor 1) • IGF2 (Insulin-like growth factor 2) • IR (Insulin receptor)
    |
    IGF1R expression • IGF1 elevation • IR overexpression
    |
    sorafenib
    12ms
    Paromomycin targets HDAC1-mediated SUMOylation and IGF1R translocation in glioblastoma. (PubMed, Front Pharmacol)
    It modulated SUMO1 expression and decreased IGF1R nuclear translocation, an effect reversible by the HDAC1 inhibitor Trochostatin A (TSA), suggesting Paromomycin's involvement in SUMO1-regulated pathways. This study highlights Paromomycin's potential as a therapeutic agent for GBM by targeting HDAC1-mediated SUMOylation pathways and influencing IGF1R translocation, warranting further investigation for its clinical application.
    Journal
    |
    IGF1R (Insulin-like growth factor 1 receptor) • HDAC1 (Histone Deacetylase 1)
    |
    IGF1R expression
    1year
    Establishing a new human lung squamous cell carcinoma cell line, OMUL-1, expressing insulin-like growth factor 1 receptor and programmed cell death ligand 1. (PubMed, Thorac Cancer)
    We developed a novel new squamous cell lung carcinoma cell line, OMUL-1, that expresses IGF1R and PD-L1.
    Preclinical • Journal • PD(L)-1 Biomarker • IO biomarker
    |
    EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • MET (MET proto-oncogene, receptor tyrosine kinase) • FGFR2 (Fibroblast growth factor receptor 2) • FGFR3 (Fibroblast growth factor receptor 3) • FGFR1 (Fibroblast growth factor receptor 1) • ERBB3 (V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • PDGFRB (Platelet Derived Growth Factor Receptor Beta) • FGFR4 (Fibroblast growth factor receptor 4) • IGF1R (Insulin-like growth factor 1 receptor) • ERBB4 (erb-b2 receptor tyrosine kinase 4) • FLT4 (Fms-related tyrosine kinase 4) • NKX2-1 (NK2 Homeobox 1) • TP63 (Tumor protein 63)
    |
    PD-L1 expression • FGFR1 expression • IGF1R expression • FGFR2 expression • FGFR2b expression • FGFR3 expression • TTF1 negative
    |
    picropodophyllin (AXL1717)
    1year
    Insulin-like growth factor 1 receptor expression correlates with programmed death ligand 1 expression and poor survival in non-small cell lung cancer. (PubMed, PLoS One)
    IGF1R may serve as a prognostic indicator and a guide for perioperative treatment strategies in early-stage lung cancer. In conclusion, our findings underscore an association between IGF1R expression and poor survival and PD-L1 expression in NSCLC.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    PD-L1 (Programmed death ligand 1) • IGF1R (Insulin-like growth factor 1 receptor)
    |
    PD-L1 expression • IGF1R expression
    1year
    Clinical relevance of long non-coding RNA in acute myeloid leukemia: A systematic review with meta-analysis. (PubMed, Leuk Res)
    The prognoses of AML patients are significantly associated with abnormally expressed lncRNAs, which may be used as prognostic indicators for predicting the patient outcomes.
    Retrospective data • Review • Journal
    |
    IGF1R (Insulin-like growth factor 1 receptor) • MALAT1 (Metastasis associated lung adenocarcinoma transcript 1) • HOTAIR (HOX Transcript Antisense RNA) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • GAS5 (Growth Arrest Specific 5) • SNHG5 (Small Nucleolar RNA Host Gene 5) • TUG1 (Taurine Up-Regulated 1)
    |
    IGF1R expression
    over1year
    RBM8A, a new target of TEAD4, promotes breast cancer progression by regulating IGF1R and IRS-2. (PubMed, J Transl Med)
    Collectively, these findings suggest that TEAD4 novel transcriptional target RBM8A interacts with EIF4A3 to increase IGF1R and IRS-2 expression and activate PI3K/AKT signaling pathway, thereby further promoting the malignant phenotype of BC cells.
    Journal
    |
    IGF1R (Insulin-like growth factor 1 receptor) • IRS2 (Insulin receptor substrate 2) • EIF4A3 (Eukaryotic Translation Initiation Factor 4A3) • RBM8A (RNA Binding Motif Protein 8A) • TEAD4 (TEA Domain Transcription Factor 4)
    |
    IGF1R expression
    over1year
    Elucidation of the anti-gastric cancer mechanism of Guiqi Baizhu Formula by integrative approach of chemical bioinformatics. (PubMed, Int Immunopharmacol)
    In summary, this study suggested that GQBZF and its key active components (glycyrol and emodin) can suppress IGF1R/PI3K/PDK1 and VEGFR2-related signaling pathway, thereby inhibiting tumor cell proliferation and migration and inducing apoptosis. These findings provided an important strategy for developing new agents and facilitated clinical use of GQBZF against GC.
    Journal
    |
    IGF1R (Insulin-like growth factor 1 receptor)
    |
    IGF1R expression • KDR expression
    almost2years
    Nutrient restriction-activated Fra-2 promotes tumor progression via IGF1R in miR-15a downmodulated pancreatic ductal adenocarcinoma. (PubMed, Signal Transduct Target Ther)
    Consistently, nutrient restriction improved the efficacy of IGF1R inhibition in a Fra-2 dependent manner. Overall, our results point to a crucial role of Fra-2 in the cellular stress response due to nutrient restriction typical of pancreatic cancer and support IGF1R as a promising and vulnerable target in miR-15a downmodulated PDAC.
    Journal
    |
    IGF1R (Insulin-like growth factor 1 receptor) • IGF1 (Insulin-like growth factor 1) • MIR15A (MicroRNA 15a)
    |
    IGF1R expression
    almost2years
    Phospholysine phosphohistidine inorganic pyrophosphate phosphatase suppresses insulin-like growth factor 1 receptor expression to inhibit cell adhesion and proliferation in gastric cancer. (PubMed, MedComm (2020))
    LHPP exerts inhibitory effects on the adhesion and proliferation of GC cells by suppressing the expression of insulin-like growth factor 1 receptor (IGF1R) and modulating downstream signaling pathways. Consequently, LHPP holds potential as a biomarker for targeted therapy involving IGF1R inhibition in GC patients.
    Journal
    |
    IGF1R (Insulin-like growth factor 1 receptor)
    |
    IGF1R expression
    2years
    Evaluation of miRNAs as potential biomarkers in leiomyosarcoma (DGHO 2023)
    Our findings suggest that miR-221, miR-320a, miR-133a, miR-133b and their targets P27kip1, TGFBR1, and IGF1R might play a critical role in the development and progression of leiomyosarcoma. It provides a plausible basis for the use of the miRNAs investigated as biomarkers in leiomyosarcoma diagnostics.
    IGF1R (Insulin-like growth factor 1 receptor) • MIR221 (MicroRNA 221) • MIR320A (MicroRNA 320a) • MIR133B (MicroRNA 133b) • TGFBR1 (Transforming Growth Factor Beta Receptor 1)
    |
    IGF1R expression