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    BIOMARKER:

    IGF1 overexpression

    i
    Other names: IGF1, IGF-I, IGF1A, IGFI, Insulin-like growth factor 1, somatomedin C
    Entrez ID:
    3479
    Related biomarkers:
    Mutation
    Others
    8ms
    Single cell and bulk RNA sequencing identifies tumor microenvironment subtypes and chemoresistance-related IGF1+ cancer-associated fibroblast in gastric cancer. (PubMed, Biochim Biophys Acta Mol Basis Dis)
    We identified four TME-based subtypes with different clinical outcomes and IGF1+ CAFs contributing to poor clinical outcomes in GC, which might provide guidance for individualized treatment and facilitate the development of novel therapeutic targets.
    Journal
    |
    MSI (Microsatellite instability) • IGF1 (Insulin-like growth factor 1)
    |
    MSI-H/dMMR • IGF1 overexpression
    over1year
    CircIGF1R_0001 mediates platinum resistance in ovarian cancer that sensitive to PARP inhibitors via promoting PARP1 binding to DNA damage sites (ESMO 2023)
    3. The circIGF1R_ 0001 acts as a potential biomarker for platinum resistance in ovarian cancer and a marker for screening patients who can benefit from PARPi after platinum resistance.
    PARP Biomarker
    |
    IGF1R (Insulin-like growth factor 1 receptor)
    |
    IGF1R expression • IGF1 overexpression