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    BIOMARKER:

    IFNG overexpression

    i
    Other names: IFNG , Interferon gamma
    Entrez ID:
    3458
    Related biomarkers:
    Expression
    Others
    over1year
    Implications of inflammatory cell death-related IFNG and co-expressed RNAs (AC006369.1 and CCR7) in breast carcinoma prognosis, and anti-tumor immunity. (PubMed, Front Genet)
    Additionally, transcription factors, RNA-binding proteins, and non-coding RNAs possibly regulated IFNG and co-expressed genes at the transcriptional and post-transcriptional levels. Collectively, our work identifies IFNG and co-expressed genes as prognostic markers for BRCA, and as possible therapeutic targets for improving the efficacy of immunotherapy.
    Journal • BRCA Biomarker • PD(L)-1 Biomarker • IO biomarker • Inflammatory cell
    |
    PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • IFNG (Interferon, gamma) • BRCA (Breast cancer early onset) • CD4 (CD4 Molecule) • CCR7 (Chemokine (C-C motif) receptor 7)
    |
    IFNG overexpression • IFNG expression
    over1year
    Systemic agonist anti-CD40 treatment delivers precise melanoma immunotherapy within established autoimmune landscapes (AACR 2023)
    Importantly, anti-CD40 alone delivered anti-tumor immune responses in type 1 IFN receptor-deficient lupus-prone mice that overexpress IFNg (Ifnar-/-ARE-/-) mice suggesting synergy with therapies blocking type 1 IFN signaling. Thus, these findings indicate that the rational use of CD40 agonists abs provide a better therapeutic platform to deliver precise anti-melanoma responses in complex autoimmune landscapes.
    PD(L)-1 Biomarker • IO biomarker
    |
    IFNG (Interferon, gamma) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • PD-L2 (Programmed Cell Death 1 Ligand 2) • IL10 (Interleukin 10) • IRF8 (Interferon Regulatory Factor 8) • PRDM1 (PR/SET Domain 1) • STAT1 (Signal Transducer And Activator Of Transcription 1) • IFNA1 (Interferon Alpha 1) • IFNAR1 (Interferon (alpha, beta and omega) receptor 1) • IFNAR2 (Interferon Alpha And Beta Receptor Subunit 2) • IFNGR1 (Interferon Gamma Receptor 1)
    |
    IFNG gene signature overexpression • IFNG overexpression • IFNG expression