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    BIOMARKER:

    IFNG gene signature overexpression

    5ms
    IFN-γ in ovarian tumor microenvironment upregulates HLA-E expression and predicts a poor prognosis. (PubMed, J Ovarian Res)
    Our study revealed the protumorigenic role of IFN-γ by upregulation of HLA-E expression and rendering tumors less susceptible to immune attack. We also provided a novel insight into the relationship between tumor microenvironment and immune evasion.
    Journal
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    IFNG (Interferon, gamma) • NCAM1 (Neural cell adhesion molecule 1) • HLA-E (Major Histocompatibility Complex, Class I, E)
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    IFNG gene signature overexpression • IFNG expression
    1year
    Systemic agonist anti-CD40 treatment delivers precise melanoma immunotherapy within established autoimmune landscapes (AACR 2023)
    Importantly, anti-CD40 alone delivered anti-tumor immune responses in type 1 IFN receptor-deficient lupus-prone mice that overexpress IFNg (Ifnar-/-ARE-/-) mice suggesting synergy with therapies blocking type 1 IFN signaling. Thus, these findings indicate that the rational use of CD40 agonists abs provide a better therapeutic platform to deliver precise anti-melanoma responses in complex autoimmune landscapes.
    PD(L)-1 Biomarker • IO biomarker
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    IFNG (Interferon, gamma) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • PD-L2 (Programmed Cell Death 1 Ligand 2) • IL10 (Interleukin 10) • IRF8 (Interferon Regulatory Factor 8) • PRDM1 (PR/SET Domain 1) • STAT1 (Signal Transducer And Activator Of Transcription 1) • IFNA1 (Interferon Alpha 1) • IFNAR1 (Interferon (alpha, beta and omega) receptor 1) • IFNAR2 (Interferon Alpha And Beta Receptor Subunit 2) • IFNGR1 (Interferon Gamma Receptor 1)
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    IFNG gene signature overexpression • IFNG overexpression • IFNG expression
    2years
    Loss of YTHDF1 in gastric tumors restores sensitivity to antitumor immunity by recruiting mature dendritic cells. (PubMed, J Immunother Cancer)
    YTHDF1 is overexpressed in GC and promotes GC by inducing cell proliferation and repression of DCs-mediated antitumor immune response. YTHDF1 is a promising therapeutic target for GC treatment.
    Journal
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    CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • CD4 (CD4 Molecule) • YTHDF1 (YTH N6-Methyladenosine RNA Binding Protein 1)
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    IFNG gene signature overexpression • IFNG expression • MHC-II expression
    over2years
    Immune Senescence-Related Gene Expression Profile in CD4+ T-Lymphocytes of HTLV-1 Asymptomatic Carriers and Patients with Adult T-Cell Leukemia/Lymphoma (ATLL): A Brazilian Preliminary Study (ASH 2021)
    These preliminaries results showed for the first time that HTLV-1 asymptomatic carriers present a set of genes differentially expressed in T-CD4+ cells, especially SPARC , TWIST1 , COL3A1 , CDNK1A and IFNG . These results will be confirmed in a validation cohort. We expected that this data shed some light on the comprehension of the cell microenvironment of the T-CD4+ lymphocyte in HTLV-1 asymptomatic carriers.
    Clinical • Gene Expression Profile
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    IFNG (Interferon, gamma) • CD4 (CD4 Molecule) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) • COL1A1 (Collagen Type I Alpha 1 Chain) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)
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    IFNG gene signature overexpression • IFNG expression • CD4 expression
    over2years
    [VIRTUAL] IMMUNE SENESCENCE-RELATED GENE EXPRESSION PROFILE IN CD4+ T-LYMPHOCYTES OF HTLV-1 ASYMPTOMATIC CARRIERS AND PATIENTS WITH ADULT T-CELL LEUKEMIA/LYMPHOMA (ATLL): A BRAZILIAN PRELIMINARY STUDY (HEMO 2021)
    We expected that this data shed some light on the comprehension of the cell microenvironment of the T-CD4+ lymphocyte in HTLV-1 asymptomatic carriers. Furthermore, we will be able to understand potential mechanisms associated with leukemogenesis in chronic infection by this virus, explaining eventual progression to ATLL.
    Clinical • Gene Expression Profile
    |
    IFNG (Interferon, gamma) • CD4 (CD4 Molecule) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) • COL1A1 (Collagen Type I Alpha 1 Chain) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)
    |
    IFNG gene signature overexpression • IFNG expression • CD4 expression