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BIOMARKER:

IFNG expression

i
Other names: IFNG , Interferon gamma
Entrez ID:
Related biomarkers:
19d
Interleukin-12 Inhibits Tumor Growth and Metastasis Promoted by Tumor-Associated Mesenchymal Stem Cells in Triple-Negative Breast Cancer. (PubMed, Cell J)
The findings of the present study revealed a complex interplay between TA-MSCs and TNBC cells that affects tumor growth and metastasis. Preclinical results indicate that intratumoral IL-12 immunotherapy shows promise in overcoming TA-MSC-promoted tumor growth and metastasis.
Journal • IO biomarker
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IFNG (Interferon, gamma) • ICAM1 (Intercellular adhesion molecule 1) • CXCL5 (Chemokine (C-X-C motif) ligand 5) • MMP3 (Matrix metallopeptidase 3)
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IFNG expression
27d
Characterization of the immune cell profile in metastatic nasopharyngeal carcinoma treated with chemotherapy and immune checkpoint inhibitors. (PubMed, Am J Cancer Res)
Responders also displayed increased levels of CD4+CD45RA-CCR7-CD28+CD57- cells (effector memory cell subset) in peripheral blood. These results indicate that in the context of combined chemotherapy and ICIs, high PD-L1 expression in pre-treated metastatic tumor tissue, a low NLR before treatment, a decrease in NLR after treatment, and local treatment can provide significant benefits for patients with metastatic NPC.
Journal • Checkpoint inhibition • PD(L)-1 Biomarker • IO biomarker
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CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • IFNG (Interferon, gamma) • CCR7 (Chemokine (C-C motif) receptor 7) • GZMB (Granzyme B) • B3GAT1 (Beta-1,3-Glucuronyltransferase 1)
|
PD-L1 expression • PD-L1 overexpression • IFNG expression
27d
Phase I trial of phIL12 plasmid intratumoral gene electrotransfer in patients with basal cell carcinoma in head and neck region. (PubMed, Eur J Surg Oncol)
The trial lays the foundation for future Phase II clinical trials in which phIL12 gene electrotransfer is used in combination with local tumor-ablative approaches, such as electrochemotherapy or radiotherapy.
P1 data • Journal
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IFNG (Interferon, gamma)
|
IFNG expression
28d
High-throughput drug screening identifies SMAC mimetics as enhancers of NK cell cytotoxicity in chronic myeloid leukemia. (PubMed, Blood)
Inhibitory drugs dexamethasone, dasatinib, and sotrastaurin prevented NK cell transition to an activated state and suppressed the expression of IFN-γ by NK cells, thus preventing IFN-γ mediated target cell transcriptomic response. In conclusion, we discovered that SMAC mimetics sensitize cancer cells to NK cell mediated killing, with potential clinical applications especially in patients with advanced phase CML.
Journal • IO biomarker
|
IFNG (Interferon, gamma)
|
IFNG expression
|
dasatinib • dexamethasone • sotrastaurin (AEB071)
28d
The anti-tumor effect of the IFNγ/Fas chimera expressed on CT26 tumor cells. (PubMed, Anim Cells Syst (Seoul))
Interestingly, splenocytes activated with the mbIFNγ/Fas-expressing tumors exhibited higher cytotoxicity than those activated with tumor cells expressing sIFNγ. These findings suggest that expressing the mbIFNγ/Fas chimera in tumor cells could be a promising strategy for developing whole tumor cell vaccines or gene therapies for cancer immunotherapy.
Journal • IO biomarker
|
CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • CD4 (CD4 Molecule)
|
IFNG expression
28d
Strengthening Effect of Thalidomide Combined with an Anti-PD1 Antibody on Enhancing Immunity for Lung Cancer Therapy. (PubMed, Curr Pharm Biotechnol)
This study highlights THD's role in modifying the tumor microenvironment to enhance PD-1 mAb efficacy, proposing a clinically feasible approach for improving PD-1 mAb treatment outcomes.
Journal • PD(L)-1 Biomarker • IO biomarker
|
PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • CD34 (CD34 molecule) • IL2 (Interleukin 2)
|
IFNG expression • CD4 expression • IL2 expression
|
thalidomide
1m
Differentiation status determines the effects of IFNγ on the expression of PD-L1 and immunomodulatory genes in melanoma. (PubMed, Cell Commun Signal)
Together, these findings indicate the existence of a molecular context linking dedifferentiation and IFNγ signaling in melanoma which may lead to immune evasion. Additionally, the variability in PD-L1 expression among MITFlow and MITFhigh cells suggests that high IFNγ-induced PD-L1 expression associates with enhanced inflammatory gene expression. These results imply that modulating melanoma differentiation may help shape IFNγ responsiveness.
Journal • PD(L)-1 Biomarker • IO biomarker
|
PD-L1 (Programmed death ligand 1) • IFNG (Interferon, gamma) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • STAT3 (Signal Transducer And Activator Of Transcription 3) • IL10 (Interleukin 10) • CCL2 (Chemokine (C-C motif) ligand 2) • IRF1 (Interferon Regulatory Factor 1) • STAT1 (Signal Transducer And Activator Of Transcription 1) • MITF (Melanocyte Inducing Transcription Factor)
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PD-L1 expression • IFNG expression • IRF1 expression
1m
The Pro-inflammatory Functions of Type 1 CD 8+ T Cells and Interleukin-17-producing Cluster of Differentiation 8+ T Cells are Exhausted by Cholesterol in Atherosclerosis. (PubMed, Iran J Immunol)
Additionally, cholesterol up-regulated 2B4 and PD-1 on Tc1 (P <0.001) and Tc17 cells (P <0.001). Aortic CD8+ T cells, particularly aortic Tc17 cells, are functionally exhausted in atherosclerosis, possibly due to the influence of cholesterol.
Journal • PD(L)-1 Biomarker • IO biomarker
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CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • TBX21 (T-Box Transcription Factor 21) • IL17A (Interleukin 17A) • APOE (Apolipoprotein E) • IL21 (Interleukin 21)
|
CD8 expression • IFNG expression
1m
Integrative analysis of ASXL family genes reveals ASXL2 as an immunoregulatory molecule in head and neck squamous cell carcinoma. (PubMed, Sci Rep)
Experimental validation showed a correlation between ASXL2 expression and T cell secretion of interferon-γ (IFNγ), confirming that high ASXL2 expression facilitates T cell activation. Overall, our findings underscore the important role of ASXL2 in immune activation, suggesting its potential as a promising biomarker for tailoring immunotherapy strategies in HNSCC patients.
Journal • IO biomarker
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IFNG (Interferon, gamma)
|
IFNG expression
2ms
Protective effect of Haoqin Qingdan decoction on pulmonary and intestinal injury in mice with influenza viral pneumonia. (PubMed, Front Pharmacol)
HQQD exerts therapeutic effects against influenza viral pneumonia through antiviral and anti-inflammatory mechanisms and by remodeling the intestinal flora. This study provides initial insights into the "gut-lung" axis mechanism of HQQD in combating respiratory influenza virus infection.
Preclinical • Journal
|
MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • IFNG (Interferon, gamma) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL1B (Interleukin 1, beta) • TLR7 (Toll Like Receptor 7)
|
IFNG expression
2ms
Human iPSC-Derived Endothelial Cells Exhibit Reduced Immunogenicity in Comparison With Human Primary Endothelial Cells. (PubMed, Stem Cells Int)
Last, multiple iPSC-EC cocultures secreted lower levels of proinflammatory cytokines than HUVEC cocultures. Collectively, iPSC-ECs manifested many similarities, but also some disparities with a generally weaker inflammatory immune response than primary ECs, indicating that iPSC-ECs may possibly exhibit hypoimmunogenicity corresponding with less risk of immune rejection in a transplant setting, which is important for safe and effective cell therapies.
Journal
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IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • CD4 (CD4 Molecule) • ICAM1 (Intercellular adhesion molecule 1) • TERC (Telomerase RNA Component) • VCAM1 (Vascular Cell Adhesion Molecule 1)
|
IFNG expression
2ms
High-affinity chimeric antigen receptor signaling induces an inflammatory program in human regulatory T cells. (PubMed, Mol Ther Methods Clin Dev)
Interestingly, decreasing CAR antigen affinity reduced Teff cell gene expression and inflammatory cytokine production by CAR Tregs. Our findings showcase the impact of engineered receptor activation on Treg biology and support tailoring CAR constructs to Tregs for maximal therapeutic efficacy.
Journal
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IFNG (Interferon, gamma) • FOXP3 (Forkhead Box P3) • CD40LG (CD40 ligand)
|
IFNG expression
2ms
Identification of Gene Regulatory Networks Associated with Breast Cancer Patient Survival Using an Interpretable Deep Neural Network Model. (PubMed, Expert Syst Appl)
Tumors with lower IFNG SHAP values exhibited higher IFNG expression and better overall survival, which were linked to more abundant presence of M1 macrophages and activated CD4+ and CD8+ T cells in the tumor microenvironment. The association of the IFNG pathway with overall survival was validated in the trastuzumab arm of the NCCTG-N9831 trial, an independent breast cancer study.
Journal
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PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • CD4 (CD4 Molecule)
|
IFNG expression
|
Herceptin (trastuzumab)
2ms
Phase 1/2 Study of the Indoleamine 2,3-Dioxygenase 1 Inhibitor Linrodostat Mesylate Combined With Nivolumab or Nivolumab and Ipilimumab in Advanced Solid Tumors or Hematologic Malignancies. (PubMed, Clin Cancer Res)
Linrodostat + nivolumab ± ipilimumab demonstrated a manageable safety profile. Kynurenine changes supported IDO1 pathway inhibition but did not correlate with response. A composite biomarker of low TDO2 expression plus high IFN-γ gene expression may predict response to linrodostat + nivolumab.
P1/2 data • Journal • PD(L)-1 Biomarker • IO biomarker • Metastases
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IFNG (Interferon, gamma) • IDO1 (Indoleamine 2,3-dioxygenase 1) • TDO2 (Tryptophan 2,3-Dioxygenase)
|
IFNG expression
|
Opdivo (nivolumab) • Yervoy (ipilimumab) • linrodostat (BMS-986205)
2ms
Oxymatrine Inhibits PD-L1 by Downregulating IFN-γ to Promote Ferroptosis and Enhance Anti-PD-L1 Efficacy in Liver Cancer. (PubMed, J Hepatocell Carcinoma)
Oxymatrine reversed IFN-γ-induced upregulation of PD-L1 expression; moreover, it downregulated xCT and GPX4 protein levels in liver cancer cells and promoted intracellular Fe2+, ROS, and MDA levels. Oxymatrine promotes tumor immune response and ferroptosis in liver cancer by downregulating IFN-γ and synergistically enhances the inhibitory effect of anti-PD-L1 on liver cancer.
Journal • PD(L)-1 Biomarker • IO biomarker
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CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • CD4 (CD4 Molecule) • GPX4 (Glutathione Peroxidase 4)
|
PD-L1 expression • IFNG expression
2ms
HMGB3 Contributes to Anti-PD-1 Resistance by Inhibiting IFN-γ-Driven Ferroptosis in TNBC. (PubMed, Mol Carcinog)
Immunohistochemistry showed HMGB3 expression correlated with ferroptosis-associated proteins and IRF1 expression in breast cancer tissue. HMGB3 contributes to anti-PD-1 resistance by inhibiting IFN-γ-driven ferroptosis in TNBC which suggested HMGB3 is a potential co-target with anti-PD-1 therapy for TNBC.
Journal • PD(L)-1 Biomarker • IO biomarker
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IFNG (Interferon, gamma) • STAT3 (Signal Transducer And Activator Of Transcription 3) • SLC3A2 (Solute Carrier Family 3 Member 2) • GPX4 (Glutathione Peroxidase 4) • IRF1 (Interferon Regulatory Factor 1) • SLC7A11 (Solute Carrier Family 7 Member 11)
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IFNG expression • IRF1 expression • GPX4 expression • SLC3A2 expression
2ms
JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia. (PubMed, EMBO Mol Med)
Skin biopsies from EGFR inhibitor-treated and cicatricial alopecia patients revealed an active JAK-STAT1 signaling signature along with upregulation of antigen presentation and downregulation of key components of the EGFR pathway. Our findings offer molecular insights and highlight a mechanism-based therapeutic strategy for addressing chronic folliculitis associated with EGFR-inhibitor anti-cancer therapy and cicatricial alopecia.
Journal
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EGFR (Epidermal growth factor receptor) • CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • JAK1 (Janus Kinase 1) • STAT1 (Signal Transducer And Activator Of Transcription 1)
|
CD8 expression • IFNG expression
2ms
Treatment of cancer-associated fibroblast-like cells with celecoxib enhances the anti-cancer T helper 1/Treg responses in breast cancer. (PubMed, Naunyn Schmiedebergs Arch Pharmacol)
Our study shows the important role of COX-2 in CAFs by promoting immune suppression. Our results suggested that high expression of COX-2 in CAFs may serve as a new therapeutic, targeting CAFs in enhancing immune responses in breast cancer treatment.
Journal
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IFNG (Interferon, gamma) • IL10 (Interleukin 10) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • TGFB1 (Transforming Growth Factor Beta 1) • FOXP3 (Forkhead Box P3) • GATA3 (GATA binding protein 3) • IL4 (Interleukin 4)
|
IFNG expression • PTGS2 expression • FOXP3 expression
|
celecoxib oral
2ms
Lithium Enhances Ferroptosis Sensitivity in Melanoma Cells and Promotes CD8+ T Cell Infiltration and Differentiation. (PubMed, Free Radic Biol Med)
We found that lithium significantly enhanced RSL3-induced ferroptosis in vitro, evidenced by increased mitochondrial peroxide, lipid peroxidation, and mitochondrial abnormalities...Additionally, this combination enhanced CD8+ T cell infiltration and IFN-γ expression in the tumor microenvironment, especially among cytotoxic effector CD8+ T cells. These findings reveal the pro-ferroptotic and immune regulation roles of lithium, broaden our understanding of its biological roles, and propose new strategies for ferroptosis-targeted therapies in melanoma.
Journal
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CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • FTH1 (Ferritin Heavy Chain 1)
|
IFNG expression
|
RSL3
2ms
Antitumor Activity and Immunostimulant Properties of Liposomes Containing Rosemary Extract on a Mouse Model of Colorectal Cancer. (PubMed, Iran J Immunol)
This study showed that PEGylated (Poly-Ethylene-Glycol) liposomes containing rosemary extract exhibit an antitumor effect on C26 colorectal cancer cells through multiple mechanisms. These findings can be utilized in future studies.
Preclinical • Journal • IO biomarker
|
IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • BAX (BCL2-associated X protein) • TGFB1 (Transforming Growth Factor Beta 1)
|
BCL2 expression • IFNG expression • BAX expression
2ms
Evening cortisol levels are prognostic for progression-free survival in a prospective pilot study of head and neck cancer patients. (PubMed, Front Oncol)
This pilot study highlights the need for research on effects of cortisol rhythm disruption among HNC patients. Future research in larger samples should also examine the role of inflammatory and tumor-promoting factors-both systemically and within the tumor microenvironment-as potential mediators of cortisol rhythm disruption.
Journal
|
IFNG (Interferon, gamma)
|
IFNG expression
2ms
Denfivontinib activates effector T-cells through NLRP3-inflammasome, yielding potent anticancer effects by combination with pembrolizumab. (PubMed, Mol Cancer Ther)
To demonstrate the extent to which our findings reflect clinical results, we analyzed bulk-RNA sequencing data from 21 NSCLC patients undergoing anti-PD-1 immunotherapy. The NLRP3 inflammasome score influenced enhanced immune responses in patient data undergoing anti-PD-1 immunotherapy, suggesting a role for NLRP3 inflammasome in activating immune responses during treatment.
Journal • PD(L)-1 Biomarker • IO biomarker
|
CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • CD4 (CD4 Molecule) • NLRP3 (NLR Family Pyrin Domain Containing 3)
|
IFNG expression
|
Keytruda (pembrolizumab) • denfivontinib (SKI-G-801)
2ms
Tumor growth suppression in adoptive T cell therapy via IFN-γ targeting of tumor vascular endothelial cells. (PubMed, Theranostics)
Early targeting of tumor vascular endothelial cells by IFN-γ led to endothelial regression, reduced perfusion, and tumor hypoxia/necrosis (Day 4.5-7). These findings highlight the critical role of T cell-derived IFN-γ action on endothelial cells early in ACT, emphasizing its dynamic influence on the tumor microenvironment, and offering insights into addressing antigen escape.
Journal • IO biomarker
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CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • STAT1 (Signal Transducer And Activator Of Transcription 1)
|
CD8 expression • IFNG expression
2ms
Function and Spatial Organization of Tumor-Invasive Human γδ T Cells-What Do We Know? (PubMed, Eur J Immunol)
Inflammatory cytokines, growth factors, or tumor promoters can suppress γδ T cell functionality or even push them toward tumor promotion. To avoid this and to exploit the unique features of γδ T cell-mediated anti-cancer and immune-orchestrating capabilities in future immune therapy approaches, a growing body of preclinical but also clinical studies can be observed.
Review • Journal
|
IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • FAS (Fas cell surface death receptor) • IL17A (Interleukin 17A)
|
IFNG expression
2ms
Tumor Microenvironment in Clear Cell Renal Cell Carcinoma: A Comprehensive Analysis. (PubMed, Iran J Public Health)
Moreover, immune infiltration and expressions of Th1/IFNγ gene signature were also significantly different between the two clusters. Our study revealed m6A regulators were important participants in the development of ccRCC, with a close relationship with the TME.
Journal
|
IFNG (Interferon, gamma)
|
IFNG expression
2ms
Pereskia bleo augments NK cell cytotoxicity against triple-negative breast cancer cells (MDA-MB-231). (PubMed, PeerJ)
P. bleo enhances NK cell activation, promoting the apoptosis of triple-negative human breast cancer cells (MDA-MB-231), suggesting the potential use of MEPB leaves as an anti-cancer immunostimulant.
Journal
|
IFNG (Interferon, gamma) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • IL10 (Interleukin 10) • GZMB (Granzyme B) • IL18 (Interleukin 18) • GZMA (Granzyme A) • PRF1 (Perforin 1)
|
IFNG expression • CXCL8 expression
2ms
Interferon Induced Upregulation of Tripartite Motif 34 (TRIM34) Leads Apoptotic Cell Death in Lung Adenocarcinoma. (PubMed, J Biochem Mol Toxicol)
With its upregulation, NCI-H23 underwent apoptosis and its rate of proliferation was impeded. Our results suggest that induction of TRIM34 by IFN-γ treatment may lead to an anti-tumor inflammatory response, resulting in NSCLC regression via apoptosis.
Journal
|
IFNG (Interferon, gamma)
|
IFNG expression
3ms
Response-Adaptive Surgical Timing in neoadjuvant immunotherapy demonstrates enhanced pathologic treatment response in Head and Neck Squamous Cell Carcinoma. (PubMed, Clin Cancer Res)
Response-adaptive surgical timing enhanced treatment response. IDO-inhibitor BMS986205 augmented pTR in patients with high IDO1-expression in baseline samples, indicating a need for identifying and targeting resistant nodes to immunotherapy. HPV-status-dependent signatures predicting response to immunotherapy in HNSCC warrant further study.
Journal • PD(L)-1 Biomarker • IO biomarker
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PD-L1 (Programmed death ligand 1) • IFNG (Interferon, gamma)
|
PD-L1 expression • IDO1 expression • IFNG expression • IDO1 overexpression
|
Opdivo (nivolumab) • linrodostat (BMS-986205)
3ms
Enhancing antitumor immunity in Lewis lung cancer through plasma-treated medium-induced activation of dendritic cells. (PubMed, Cancer Cell Int)
Overall, this research introduces a promising avenue for improving lung cancer treatment using PTM to stimulate an immune response and induce cell death in tumor cells. Further studies will be essential to validate these findings and explore clinical applications.
Journal • PD(L)-1 Biomarker • IO biomarker
|
CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • CD4 (CD4 Molecule) • STAT1 (Signal Transducer And Activator Of Transcription 1) • CAT (Catalase)
|
PD-L1 expression • IFNG expression
3ms
Antileishmanial and synergic effects of Rhanterium epapposum essential oil and its main compounds alone and combined with glucantime against Leishmania major infection. (PubMed, Int J Parasitol Drugs Drug Resist)
Topical treating CL-infected mice with REE and its main compounds alone particularly in conjunction with GC, significantly increased (p < 0.001) the expression levels of IFN-γ and interleukin (IL-12), while also causing a notable reduction in IL-4 expression. The findings of the current experimental research revealed the high in vitro and in vivo antileishmanial efficacy of REE and its main compounds MC, CP, and LN mainly in combination with GC; which indicated the high synergic effects of these compounds.
Journal
|
IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • IL4 (Interleukin 4)
|
IFNG expression
3ms
Targeting METTL3 as a checkpoint to enhance T cells for tumour immunotherapy. (PubMed, Clin Transl Med)
Targeting METTL3 augments tumour cell immunogenicity and sustains T-cell function. T cell with METTL3 inhibition can reverse T-cell exhaustion, and promote expression of IFNγ and GzmB, thereby enhancing cytotoxicity in anti-PD-1 therapy. YTHDF2 deletion in tumours prolong the lifespan of MHC-I mRNAs.
Journal • PD(L)-1 Biomarker • IO biomarker
|
IFNG (Interferon, gamma) • GZMB (Granzyme B) • METTL3 (Methyltransferase Like 3) • YTHDF2 (YTH N6-Methyladenosine RNA Binding Protein 2)
|
IFNG expression
3ms
Newcastle disease virus promotes pyroptosis in medulloblastoma cells by regulating interferon-gamma-mediated guanylate-binding protein 1 expression and activating caspase-4. (PubMed, Cytojournal)
The silencing of caspase-4 confirmed the regulatory role of GBP1 in MB cell pyroptosis. Our findings suggest that NDV elevates IFN-g and GBP1 expression in MB cells, potentially contributing to caspase-4-mediated pyroptosis activation.
Journal
|
IFNG (Interferon, gamma) • GBP1 (Guanylate Binding Protein 1) • CASP4 (Caspase 4) • CASP1 (Caspase 1)
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IFNG expression • GBP1 overexpression • IFNG elevation
3ms
CD38 modulates cytokine secretion by NK cells through the Sirt1/NF-κB pathway, suppressing immune surveillance in colorectal cancer. (PubMed, Sci Rep)
The supernatants of CRC CD38 + NK culture promoted M0 macrophage polarization to M2-type. We suggest that CD38 modulates cytokine secretion by NK cells through Sirt1/NF-κB signaling pathway, thereby suppressing immune surveillance in tumorigenesis.
Journal
|
IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • CD4 (CD4 Molecule) • IL10 (Interleukin 10) • TGFB1 (Transforming Growth Factor Beta 1)
|
IFNG expression
3ms
FOXA1 enhances antitumor immunity via repressing interferon-induced PD-L1 expression in nasopharyngeal carcinoma. (PubMed, J Immunother Cancer)
We demonstrated that FOXA1 prevents tumor immune evasion by inhibiting IFN-γ induced PD-L1 expression in NPC cells. Our research findings provide new insights into the immunotherapeutic biomarkers and targets for NPC, which is important for the clinical application of programmed cell death protein-1/PD-L1 antibodies in NPC.
Journal • PD(L)-1 Biomarker • IO biomarker
|
PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • IFNG (Interferon, gamma) • FOXA1 (Forkhead Box A1) • IRF1 (Interferon Regulatory Factor 1) • STAT1 (Signal Transducer And Activator Of Transcription 1)
|
PD-L1 expression • PD-L1 overexpression • IFNG expression • IRF1 expression
|
Tecentriq (atezolizumab)
3ms
Neutrophils promote the activation of monocytes via ROS to boost systemic antitumor immunity after cryo-thermal therapy. (PubMed, Front Immunol)
Adoptive neutrophil transfer further enhanced the antitumor efficacy of CTT in tumor models of spontaneous and experimental metastasis. These results reveal the important role of neutrophil‒monocyte interactions in the development of anti-tumor immunity and highlight that CTT could be used as an immunotherapy for targeting neutrophils and monocytes to enhance antitumor immunity.
Journal • IO biomarker
|
IFNG (Interferon, gamma)
|
IFNG expression
3ms
KRas plays a negative role in regulating IDO1 expression. (PubMed, Transl Oncol)
Treatment with the KRasG12C-specific inhibitor, ARS-1620, significantly increased IDO1 expression, which inversely correlated with PD-L1 expression in the KRasG12C-mutant H358 cell line...Moreover, the induction of IDO1 expression following KRas inhibition appears to operate independently of the MAPK pathway. Our results propose that concurrent targeting of KRas and IDO1 could potentiate therapeutic efficacy in KRas-mutant cancers, overcoming resistance to immune checkpoint blockade.
Journal • PD(L)-1 Biomarker • IO biomarker
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PD-L1 (Programmed death ligand 1) • KRAS (KRAS proto-oncogene GTPase) • PD-1 (Programmed cell death 1) • IFNG (Interferon, gamma) • IDO1 (Indoleamine 2,3-dioxygenase 1)
|
PD-L1 expression • KRAS G12C • RAS mutation • IDO1 expression • IFNG expression • KRAS G12C + PD-L1 expression • KRAS expression
|
ARS-1620
3ms
Apolipoprotein A1-encoding recombinant adenovirus remodels cholesterol metabolism in tumors and the tumor microenvironment to inhibit hepatocellular carcinoma. (PubMed, Transl Res)
Ad5-ApoA1 activates CD8+ T cells by promoting large-scale viral replication. High levels of ApoA1 protein expression promote cholesterol efflux, inhibit CD8+ T cell depletion, and reduce inflammatory factors, ultimately leading to superior therapeutic effects on hepatocellular carcinoma.
Journal • PD(L)-1 Biomarker • IO biomarker
|
CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • LAG3 (Lymphocyte Activating 3) • GZMB (Granzyme B) • APOA1 (Apolipoprotein A-I)
|
PD-1 expression • LAG3 expression • IFNG expression
3ms
High-throughput proliferation and activation of NK-92MI cell spheroids via a homemade one-step closed bioreactor in pseudostatic cultures for immunocellular therapy. (PubMed, J Biol Eng)
Moreover, these cells presented elevated levels of IFN-γ expression after IL-18 activation, resulting in enhanced NK cell-mediated cytotoxicity against K562 cells. This innovative strategy, which uses a closed suspension-based culture system, presents a promising approach for improving cell expansion and activation techniques in immunocellular therapy.
Journal • Immune cell
|
IFNG (Interferon, gamma) • IL18 (Interleukin 18)
|
IFNG expression
3ms
Effect of chitosan nanogels loaded with vancomycin and gamma interferon on TNF-α gene expression in macrophage cell line activated with methicillin-resistant Staphylococcus aureus (MRSA). (PubMed, Iran J Microbiol)
In group 4 in comparison to the MRSA group, TNF-α expression decreased significantly following 24 hours. Loading of vancomycin and IFN-γ in the chitosan nanogel can reduce TNF-α gene expression on MRSA infected cell lines.
Preclinical • Journal
|
IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha)
|
IFNG expression
3ms
Echinacoside inhibits tumor immune evasion by downregulating inducible PD-L1 and reshaping tumor immune landscape in breast and colorectal cancer. (PubMed, Phytomedicine)
ECH upregulates the expression of inducible PD-L1 through the JAK/STAT1/IRF1 signaling pathway, enhances T cell function, and reshapes the tumor immune landscape into an anti-tumor phenotype. Importantly, ECH markedly enhances the efficacy of ICB treatment, indicating its potential application in anti-tumor therapy.
Journal • PD(L)-1 Biomarker • IO biomarker
|
PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • CD4 (CD4 Molecule)
|
PD-L1 expression • IFNG expression • IRF1 expression
3ms
Immune activation of tumor cells and microenvironment as assessed by PD-L1 expression and interferon gamma signaling predict long term disease-free and overall survival: Results of the prospective randomized neoadjuvant ABCSG 34 trial (SABCS 2024)
Patients were randomized 1:1 to receive either Standard of Care (SoC) or SoC plus the MUC1-based antitumor vaccine tecemotide... The results of this study indicate that in the ABCSG 34 trial, PD-L1 positivity as determined by IC and CPS was able to predict better DRFS and OS. However, in patients with residual tumor, an increase in CPS during treatment was associated with decreased OS - a result that needs to be interpreted with caution, since no "post treatment sample" can be accessed in cases of pCR. In addition, IRF1 expression both in tumor cells and TILs predicted an improved IDFS and DRFS.
Clinical • PD(L)-1 Biomarker • IO biomarker • Tumor cell
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HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • IFNG (Interferon, gamma) • MUC1 (Mucin 1) • IRF1 (Interferon Regulatory Factor 1) • STAT1 (Signal Transducer And Activator Of Transcription 1)
|
PD-L1 expression • HER-2 negative • IFNG expression • IRF1 expression
|
VENTANA PD-L1 (SP263) Assay • VENTANA PD-L1 (SP142) Assay
|
Stimuvax (tecemotide)
4ms
Conditioned media from human adipose tissue-derived mesenchymal stem cells: potential effect on peripheral blood mononuclear cells in co-culture with HeLa cell line. (PubMed, Cytotechnology)
This observation indicates their promising potential as immunomodulatory therapies for cervical cancer cells. Nevertheless, additional investigation is imperative to comprehensively comprehend the fundamental mechanisms and refine therapeutic strategies involving PBMCs and mesenchymal stem cells.
Preclinical • Journal
|
IFNG (Interferon, gamma) • IL2 (Interleukin 2) • TGFB1 (Transforming Growth Factor Beta 1)
|
IFNG expression • IL2 expression